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Sökning: LAR1:gu > Thelle Dag 1942 > Mehlig Kirsten

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  • Mehlig, Kirsten, 1964-, et al. (författare)
  • CETP TaqIB genotype modifies the association between alcohol and coronary heart disease: The INTERGENE case-control study
  • 2014
  • Ingår i: Alcohol. - 0741-8329. ; 48:7, s. 695-700
  • Tidskriftsartikel (refereegranskat)abstract
    • Alcohol consumption at moderate levels has been associated with decreased risk of coronary heart disease (CHD). However, the cardio-protective effect of alcohol may be restricted to subjects with a particular genotype of the cholesteryl ester transfer protein (CETP) polymorphism. There is evidence for this from one study in men, but the finding has not been confirmed since. The present study specifically re-examines the potential modification of the association between alcohol consumption and CHD by the CETP TaqIB (rs708272) polymorphism in a sample including both men and women. The INTERGENE case-control study consists of 618 patients with CHD and 2921 control subjects, of whom 19% were homozygous for the CETP TaqIB B2 allele. Alcohol consumption was categorized into sex-specific tertiles of ethanol intake, with non-drinkers constituting a separate category. Logistic regression was used to determine the association between CHD with genotype, ethanol intake, and their interaction. Participants with intermediate ethanol intake (2nd tertile) had lower risk of CHD than those with low ethanol intake (odds ratio [OR] = 0.65; 95% confidence interval [Cl] 0.50-0.85). The strongest protective association was seen in the CETP TaqIB B2 homozygotes for intermediate vs. low ethanol intake (odds ratio OR = 0.21; 95% CI 0.10-0.44). The interaction between ethanol intake and genotype was statistically significant (p = 0.008), and of similar size in men and women though significant only in men (p = 0.01). The effect modification could not be explained by differences in lifestyle, socioeconomics, or alcohol-related biological variables such as HDL-cholesterol. Our study is the first to replicate previous findings of an effect modification in men. It gives only suggestive results for women, possibly due to the small number of female cases (n = 165). The prevented fraction for the favorable combination of genotype and alcohol consumption is about 6%, a value suggesting that the cardio-protective effect of moderate alcohol consumption applies only to a small segment of the general population. (C) 2014 The Authors. Published by Elsevier Inc.
  • Mehlig, Kirsten, 1964-, et al. (författare)
  • Cohort Profile: The INTERGENE Study.
  • 2017
  • Ingår i: International journal of epidemiology. - 1464-3685. ; 46:6, s. 1742-1743h
  • Tidskriftsartikel (refereegranskat)abstract
    • In 2001, the INTERGENE research programme established a population-based cohort of 3614 adults living in south-western Sweden. The aim was to assess environmental, lifestyle and hereditary risk factors for cardio-metabolic and respiratory diseases, and to document secular changes in many of these characteristics. Because the focus is on coronary heart disease (CHD), the population cohort was complemented with 618 patients with acute or chronic CHD who were sampled during the examination period for the cohort (2001–04), following the same protocol. More than 800 variables describe lifestyle and socio-demographic characteristics from questionnaires, anthropometric characteristics from physical examinations, and biomarkers from blood sampled during the examination. Additional blood samples and extracted DNA are stored in biobanks. Data from the case-control study of CHD were used to investigate associations between common risk factors (overweight, smoking, alcohol consumption, sedentary behaviour) and different candidate genes with respect to CHD, and explore interactions. In addition, a biomarker for airway inflammation (Fraction of Exhaled Nitric Oxide, FENO) was investigated as a risk factor for respiratory disease, and collaboration was established with international consortia to identify genes related to respiratory and cardiovascular diseases. An update of registry information on cohort members from hospitals, general practitioners and pharmacies provides a wide spectrum of incident diagnoses and treatments between 2001 and 2014. A recently completed longitudinal follow-up of the baseline cohort will provide a further measurement point to describe changing cardiovascular risk factors in south-west Sweden. Participation at baseline was 42%, and 61% of these participated at the follow-up.
  • Tognon, Gianluca, 1976-, et al. (författare)
  • Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. Focus on Obesity, Diet and Alcohol Intake.
  • 2012
  • Ingår i: PloS one. - 1932-6203. ; 7:7
  • Tidskriftsartikel (refereegranskat)abstract
    • The ratio between apolipoprotein B and apolipoprotein A-I (apoB/apoA-I) has been suggested to be a powerful and more accurate predictor of future cardiovascular disease risk than total cholesterol and HDL cholesterol. Since diet and lifestyle can directly influence dyslipidemia, it is of interest to identify modifiable factors that are associated with high levels of the apolipoprotein ratio and if they can have a different association with a more traditional indicator of cardiovascular risk such as total cholesterol/HDL. The relationship between obesity and dyslipidemia is established and it is of interest to determine which factors can modify this association. This study investigated the cross-sectional association of obesity, diet and lifestyle factors with apoB/apoA-I and total cholesterol/HDL respectively, in a Swedish population of 2,907 subjects (1,537 women) as part of the INTERGENE study. The apolipoprotein and lipoprotein ratios were highly correlated, particularly in women, and obesity was strongly associated with both. Additionally, age, cigarette smoking and alcohol intake were important determinants of these ratios. Alcohol was the only dietary factor that appreciably attenuated the association between obesity and each of the ratios, with a stronger attenuation in women. Other dietary intake and lifestyle-related factors such as smoking status and physical activity had a lower effect on this association. Because the apolipoprotein and lipoprotein ratios share similar diet and lifestyle determinants as well as being highly correlated, we conclude that either of these ratios may be a sufficient indicator of dyslipidemia.
  • Zylberstein, Dimitri, 1951-, et al. (författare)
  • Midlife homocysteine and late-life dementia in women. A prospective population study.
  • 2011
  • Ingår i: Neurobiology of aging. - 1558-1497. ; 32:3, s. 380-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Elevated serum total homocysteine (tHcy) is an established risk factor for cardiovascular disease. Its role in dementia is still controversial, and no study has examined the role of midlife tHcy, or reports longer than 8 years of follow-up. We examined the relation between midlife tHcy and late-life dementia in women followed for 35 years. The Prospective Population Study of Women in Gothenburg began in 1968-1969, comprising a representative population of women aged 38-60 years. Four extensive follow-ups were conducted by 2003. Serum samples from 1968 to 1969 were analysed for tHcy in 1368 women. In total, 151 women developed dementia. The highest tHcy tertile was related to a hazard ratio of 1.7 (95% CI 1.1-2.6) for developing any dementia, 2.1 (95% CI 1.2-3.7, n=100) for AD and 2.4 (95% CI 1.3-4.7, n=68) for AD without cerebrovascular disease. Kaplan-Meier plots showed divergence with respect to dementia after 22 years of follow-up. In conclusion, high homocysteine in midlife is an independent risk factor for the development of late-life Alzheimer dementia in women.
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