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Träfflista för sökning "LAR1:gu ;pers:(Wallin Anders 1950);pers:(Blennow Kaj 1958);pers:(Rüetschi Ulla 1962)"

Sökning: LAR1:gu > Wallin Anders 1950 > Blennow Kaj 1958 > Rüetschi Ulla 1962

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1.
  • Andreasen, Niels, et al. (författare)
  • Amyloid beta1-40 quantification in CSF: comparison between chromatographic and immunochemical methods.
  • 2007
  • Ingår i: Dementia and geriatric cognitive disorders. - 1420-8008. ; 23:4, s. 246-50
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND/AIMS: Amyloid beta (Abeta) is the principal component of senile plaques, one of the hallmarks of Alzheimer's disease (AD). Evidence is accumulating that soluble aggregates (oligomers) of Abeta are important in the pathogenesis of AD. METHODS: We compared three different methods for quantification of the 40 amino acid form of Abeta (Abeta40) in CSF, two based on antibodies [ELISA and surface-enhanced laser desorption/ionization-time of flight (SELDI-TOF) with antibody-coated arrays] and one based on direct binding of proteins to a protein array [SELDI-TOF and immobilized metal affinity [copper] (IMAC30)]. RESULTS: CSF Abeta40 concentration was only found to be significantly elevated in AD (127% of control levels; p=0.0095) using SELDI-TOF with IMAC30 arrays. CONCLUSIONS: These data suggest that the measured Abeta level in CSF may differ depending on whether antibody-based methods are used or not, possibly caused by epitope masking due to Abeta oligomerization or to binding of Abeta to carrier proteins.
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2.
  • Folkesson Hansson, Sara, 1976-, et al. (författare)
  • Cystatin C in cerebrospinal fluid and multiple sclerosis
  • 2007
  • Ingår i: Ann Neurol. ; 62:2, s. 193-196
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS). METHODS: Surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects. RESULTS: Full-length CysC (13.4kDa) concentration was similar in MS and control samples. The 12.5kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C. INTERPRETATION: The 12.5kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS. Ann Neurol 2007;62:193-196.
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3.
  • Hansson, Sarah, 1976-, et al. (författare)
  • Cystatin C in cerebrospinal fluid and multiple sclerosis.
  • 2007
  • Ingår i: Annals of neurology. - 0364-5134. ; 62:2, s. 193-6205
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5 kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS). METHODS: Surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects. RESULTS: Full-length CysC (13.4 kDa) concentration was similar in MS and control samples. The 12.5 kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C. INTERPRETATION: The 12.5 kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS.
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