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Träfflista för sökning "LAR1:gu ;pers:(Wallin Anders 1950);pers:(Blennow Kaj 1958);srt2:(2010);pers:(Zetterberg Henrik 1973)"

Sökning: LAR1:gu > Wallin Anders 1950 > Blennow Kaj 1958 > (2010) > Zetterberg Henrik 1973

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1.
  • Eckerström, Carl, et al. (författare)
  • Combination of Hippocampal Volume and Cerebrospinal Fluid Biomarkers Improves Predictive Value in Mild Cognitive Impairment.
  • 2010
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - 1421-9824. ; 29:4, s. 294-300
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Mild cognitive impairment (MCI) is a heterogeneous condition, and the prognosis differs within the group. Recent findings suggest that hippocampal volumetry and CSF biomarkers can be used to predict which MCI patients have an underlying neurodegenerative disorder. Objective: To examine the combined predictive value of hippocampal volume and CSF levels of total tau (T-tau) and beta-amyloid(42) (Abeta(42)) in stable and converting MCI patients. The participants (n = 68) included patients with MCI at baseline and who converted to dementia by the time of the 2-year follow-up (n = 21), stable MCI patients (n = 21) and healthy controls (n = 26). Methods: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually, based on data from the 0.5-tesla MRI investigations at baseline. Baseline CSF levels of T-tau and Abeta(42) were measured using commercially available, enzyme-linked immunosorbent assays. Results: The converting MCI group had significantly smaller left hippocampi, lower CSF Abeta(42) and higher T-tau compared to both the stable MCI group and the healthy controls. Multivariate analysis revealed that a combination of the variables outperformed the prognostic ability of the separate variables. Conclusions: Hippocampal volumes supplement the prognostic accuracy of CSF Abeta(42) and T-tau in MCI.
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2.
  • Jonsson, Michael, 1955-, et al. (författare)
  • Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study.
  • 2010
  • Ingår i: European journal of neurology. - 1468-1331. ; 17:3, s. 377-382
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and purpose: White matter lesions (WMLs) caused by small vessel disease are common in elderly people and contribute to cognitive impairment. There are no established biochemical markers for WMLs. We aimed to study the relation between degree of WMLs rated on magnetic resonance imaging of the brain and cerebrospinal fluid (CSF) levels of structural biomarkers associated with Alzheimer's disease (AD) and subcortical vascular dementia. Methods: Fifty-three non-demented elderly individuals with WMLs were subjected to lumbar puncture. Degree of WMLs was rated using the Fazekas scale. Volumetric assessment of WMLs was performed. CSF samples were analyzed for the 40 and 42 amino acid fragments of amyloid beta, alpha- and beta-cleaved soluble amyloid precursor protein, total tau (T-tau), hyperphosphorylated tau (P-tau(181)), neurofilament light protein (NFL), sulfatide and CSF/Serum-albumin ratio. Results: Fifteen subjects had mild, 23 had moderate and 15 had severe degree of WMLs. CSF-NFL levels differed between the groups (P < 0.001) and correlated with the volume of WMLs (r = 0.477, P < 0.001). CSF sulfatide concentration displayed similar changes but less strongly. T-tau, P-tau(181) and the different amyloid markers as well as CSF/S-albumin ratio did not differ significantly between the groups. Conclusions: The association of increased CSF-NFL levels with increasing severity of WMLs in non-demented subjects suggests that NFL is a marker for axonal damage in response to small vessel disease in the brain. This manifestation may be distinct from or earlier than the neurodegenerative process seen in AD, as reflected by the lack of association between WMLs and AD biomarkers.
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3.
  • Rolstad, Sindre, 1976-, et al. (författare)
  • High Education May Offer Protection Against Tauopathy in Patients with Mild Cognitive Impairment.
  • 2010
  • Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 21:1, s. 221-8
  • Tidskriftsartikel (refereegranskat)abstract
    • The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau and amyloid-beta{42}, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy.
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4.
  • Thorvaldsson, Valgeir, 1976-, et al. (författare)
  • Memory in individuals with mild cognitive impairment in relation to APOE and CSF Abeta42.
  • 2010
  • Ingår i: International psychogeriatrics / IPA. - 1741-203X. ; 22:4, s. 598-606
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The epsilon4 allele of the apolipoprotein E (APOE) gene and low levels of cerebrospinal fluid (CSF) amyloid beta-proteins 42 (Abeta) have previously been associated with increased risk of cognitive decline in old age. In this study we examine the interaction of these markers with episodic memory in a sample identified as having mild cognitive impairment (MCI). METHODS: The sample (N = 149) was drawn from the Gothenburg MCI study and measured according to three free recall tests on three occasions spanning over four years. Second-order Latent Curve Models (LCM) were fitted to the data. RESULTS: Analyses accounting for age, gender, education, APOE, Abeta42, and interaction between APOE and Abeta42 revealed that the epsilon4 allele was significantly associated with level of memory performance in the presence of low Abeta42 values (< or = 452 ng/L). Associations between memory performance and Abeta42 were significant among the epsilon4 carriers but not among the non-carriers. The Abeta42 marker was, however, significantly associated with changes in memory over the study time period in the total sample. CONCLUSION: The findings support the hypothesis of an interactive effect of APOE and Abeta42 for memory decline in MCI patients.
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