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- Downham, David, et al.
(författare)
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Distribution of different fibre types in human skeletal muscles: A method for the detection of neurogenic disorders
- 1987
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Ingår i: IMA journal of mathematics applied in medicine and biology. - : Oxford University Press (OUP). - 0265-0746 .- 1471-6879. ; 4:1, s. 81-91
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Tidskriftsartikel (refereegranskat)abstract
- Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The negative binomial distribution is shown to fit closely, where the parameters can be expressed in terms of the number of fibres and the fibre type proportion in a sample area. This result permits the calculation of significance levels for a sample area and the combination of information in several sample areas. Finally, the method is applied to whole cross-sections of 24 male human autopsied muscles.
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| 2. |
- Lexell, Jan, et al.
(författare)
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Morphological detection of neurogenic muscle disorders : how can statistical methods aid diagnosis?
- 1987
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Ingår i: Acta Neuropathologica. - 0001-6322 .- 1432-0533. ; 75:2, s. 109-115
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Tidskriftsartikel (refereegranskat)abstract
- The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development
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