| 1. |
- Ponsot, Elodie, 1973-, et al.
(författare)
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Skeletal muscle telomere length is not impaired in healthy physically active old women and men
- 2008
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Ingår i: Muscle and Nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 37:4, s. 467-472
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Tidskriftsartikel (refereegranskat)abstract
- We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory mechanisms allowing the maintenance of telomere length. These results imply that moderate physical activity regularly performed by old subjects is not associated with accelerated telomere loss.
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| 2. |
- Ambrosio, Fabrisia, et al.
(författare)
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The effect of muscle loading on skeletal muscle regenerative potential : an update of current research findings relating to aging and neuromuscular pathology
- 2009
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Ingår i: American Journal of Physical Medicine & Rehabilitation. - Baltimore : Lippincott Williams & Wilkins. - 0894-9115 .- 1537-7385. ; 88:2, s. 145-155
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Forskningsöversikt (refereegranskat)abstract
- Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.
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| 3. |
- Drake, Anna Maria, et al.
(författare)
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Reproducibility of isokinetic ankle dorsiflexor strength and fatigue measurements in healthy older subjects.
- 2007
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Ingår i: Isokinetics and Exercise Science. - 1878-5913 .- 0959-3020. ; 15:4, s. 263-270
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine the test-retest (two occasions seven days part) reproducibility of isokinetic (Biodex) concentric (CON) and eccentric (ECC) ankle dorsiflexor strength and fatigue measurements in older subjects using several statistical methods. Thirty healthy men (n=15) and women (n=15) aged between 70 and 85 years participated in the study. To determine the reproducibility of strength measurements, the 30 individuals performed three maximal CON and ECC contractions at 30°/s and 90°/s. The intraclass correlation coefficient (ICC_{2.1}) for CON and ECC strength measurements was high and ranged from 0.94 to 0.98. Bland & Altman graphs and analyses indicted no systematic bias. The standard error of measurement (SEM), representing the smallest change that indicates a real improvement (or deterioration) for a group of individuals, was small (< 2.3 Nm). The smallest real difference (SRD), representing the smallest detectable change that indicates a real improvement (or deterioration) for a single subject, was also small ('error bands' from −7.2 Nm to 5.6 Nm). A high correlation (Pearson's r > 0.94) between CON peak torque at 30°/s and 90°/s, as well as ECC peak torque at 30°/s and 90°/s, suggested that any of these two velocities could be used as a reference. To determine the reproducibility of fatigue measurements, 28 of the 30 individuals performed 50 maximal CON contractions at 60°/s. Reproducibility of the loss in work (work fatigue) and the relative loss in peak torque, comparing the first three to the last three contractions (3-3), was determined and the ICC was 0.71 and 0.60, respectively. In addition, the SEM was small (< 8.4%) and the 'error bands' to define the SRD for a single subject were also small (from −23.5% to 24.5%). In conclusion, these values indicate small measurement errors and thus provide a clinically acceptable basis for testing ankle dorsiflexion strength and fatigue of the dominant side in healthy older people.
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| 4. |
- Isaksson, Gunilla, et al.
(författare)
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To regain participation in occupations through human encounters : narratives from women with spinal cord injury
- 2007
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Ingår i: Disability and Rehabilitation. - : Informa UK Limited. - 0963-8288 .- 1464-5165. ; 29:22, s. 1679-1688
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Tidskriftsartikel (refereegranskat)abstract
- Purpose. To gain an understanding of how women with spinal cord injury (SCI) experienced human encounters in occupations and how these influenced their participation. Method. The data were collected through two or three in-depth interviews with 13 women (age 25 - 61 years) with SCI. Data analysis was carried out by using a paradigmatic analysis of narrative data, followed by an interpretation based on a narrative theory. Results. The results showed a complexity where the women's experiences and acting in human encounters changed over time. In these human encounters the women struggled with conflicts, supported other persons that were insecure and revaluated their apprehension about persons in their social network. These multidimensional human encounters thereby enabled them to regain participation in occupations. Conclusions. This shows that human encounters are important for persons with disabilities so they can restructure their occupational identity and their needs for participation in occupations. The study also showed that the use of narratives as a tool within rehabilitation could lead to an increased understanding of the subjective changes that occur over time for a person with a disability
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| 5. |
- Isaksson, Gunilla, et al.
(författare)
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Women's perception of changes in the social network after a spinal cord injury
- 2005
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Ingår i: Disability and Rehabilitation. - : Informa UK Limited. - 0963-8288 .- 1464-5165. ; 27:17, s. 1013-1021
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To describe how women with a spinal cord injury (SCI) perceived changes in the social network, and how these changes affected their ability to participate in occupation. METHOD: Thirteen women, aged 25 to 61 years, with a SCI were interviewed twice. The interviews focused on their ability to participate in occupation, their relations with individuals within the social network, and changes in the social network following the SCI. The analysis was carried out using qualitative content analysis. RESULTS: The women described an emotional need for social support after the SCI to participate in occupation. This was a new experience that required time to adapt to. The women also described a need for practical social support from the social network members to manage meaningful occupation. After the SCI, the women had developed new habits through close cooperation with members in the social network. The women felt that they had become more responsible for the development of their relations. Many relations had improved after the SCI, while some had decreased. The women had also developed new relations with other persons with disabilities. CONCLUSIONS: The women perceived substantial changes in the social network following the SCI, which in several ways affected their ability to participate in occupation. To adapt to their new life situation, the women gradually developed different strategies. The results point out the need to identify persons in the social network that women with SCI develop relations with, and integrate them in the rehabilitation process.
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| 6. |
- Jumisko, Eija, et al.
(författare)
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Living with moderate or severe traumatic brain injury : The meaning of family members' experiences
- 2007
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Ingår i: Journal of Family Nursing. - : SAGE Publications. - 1074-8407 .- 1552-549X. ; 13:3, s. 353-369
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Tidskriftsartikel (refereegranskat)abstract
- Traumatic brain injury (TBI) has long-lasting consequences not only for the individual with the injury but also for family members. The aim of this study is to elucidate the meaning of family members' experiences of living with an individual with moderate or severe TBI. The data have been collected by means of qualitative research interviews with 8 family member participants. A phenomenological hermeneutic interpretation (Ricouer, 1976) of the data reveal that family members struggle with their own suffering while showing compassion for the injured person. Their willingness to assume care for the injured person is derived from their feeling of natural love and the ethical demand to be responsible for the other. Hope and natural love from close relatives, the afflicted person, and other family members give the family members strength. It is important that professionals pay more attention to the suffering of close relatives.
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| 7. |
- Kadi, Fawzi, et al.
(författare)
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Satellite cells and myonuclei in young and elderly women and men
- 2004
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Ingår i: Muscle and Nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 29:1, s. 120-127
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Tidskriftsartikel (refereegranskat)abstract
- The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had a significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P < 0.004) number of myonuclei per muscle fiber. The number of satellite cells relative to the total number of nuclei [satellite cells/(myonuclei + satellite cells)] was significantly lower in the elderly than in the young women and men. These results imply that a reduction in the satellite cell population occurs as a result of increasing age in healthy men and women.
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| 8. |
- Kadi, Fawzi, et al.
(författare)
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The behaviour of satellite cells in response to exercise : what have we learned from human studies?
- 2005
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Ingår i: Pflügers Archiv. - : Springer Science and Business Media LLC. - 0031-6768 .- 1432-2013. ; 451:2, s. 319-327
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Understanding the complex role played by satellite cells in the adaptive response to exercise in human skeletal muscle has just begun. The development of reliable markers for the identification of satellite cell status (quiescence/activation/proliferation) is an important step towards the understanding of satellite cell behaviour in exercised human muscles. It is hypothesised currently that exercise in humans can induce (1) the activation of satellite cells without proliferation, (2) proliferation and withdrawal from differentiation, (3) proliferation and differentiation to provide myonuclei and (4) proliferation and differentiation to generate new muscle fibres or to repair segmental fibre injuries. In humans, the satellite cell pool can increase as early as 4 days following a single bout of exercise and is maintained at higher level following several weeks of training. Cessation of training is associated with a gradual reduction of the previously enhanced satellite cell pool. In the elderly, training counteracts the normal decline in satellite cell number seen with ageing. When the transcriptional activity of existing myonuclei reaches its maximum, daughter cells generated by satellite cell proliferation are involved in protein synthesis by enhancing the number of nuclear domains. Clearly, delineating the events and the mechanisms behind the activation of satellite cells both under physiological and pathological conditions in human skeletal muscles remains an important challenge.
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| 9. |
- Larsson, Agneta, et al.
(författare)
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Effects of work ability and health promoting interventions for women with musculoskeletal symptoms : A 9-month prospective study
- 2008
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Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 9, s. 105-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Women working in the public human service sector in 'overstrained' situations run the risk of musculoskeletal symptoms and long-term sick leave. In order to maintain the level of health and work ability and strengthen the potential resources for health, it is important that employees gain greater control over decisions and actions affecting their health - a process associated with the concept of self-efficacy. The aim of this study was to describe the effects of a self-efficacy intervention and an ergonomic education intervention for women with musculoskeletal symptoms, employed in the public sector.Methods: The design of the study was a 9-month prospective study describing the effects of two interventions, a comprehensive self-efficacy intervention (n = 21) and an ergonomic education intervention ( n = 21). Data were obtained by a self-report questionnaire on health-and work ability-related factors at baseline, and at ten weeks and nine months follow-up. Within-group differences over time were analysed.Results: Over the time period studied there were small magnitudes of improvements within each group. Within the self-efficacy intervention group positive effects in perceived work ability were shown. The ergonomic education group showed increased positive beliefs about future work ability and a more frequent use of pain coping strategies.Conclusion: Both interventions showed positive effects on women with musculoskeletal symptoms, but in different ways. Future research in this area should tailor interventions to participants' motivation and readiness to change.
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| 10. |
- Larsson Lund, Maria, et al.
(författare)
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Perceived participation in life situations in persons with late effects of polio
- 2008
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Ingår i: Journal of Rehabilitation Medicine. - Uppsala : Medical Journals Sweden AB. - 1651-2081 .- 1650-1977. ; 40:8, s. 659-664
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate how persons with late effects of polio perceive their participation and problems with participation in life situations and to determine the association between perceived problems with participation and sex, age, marital status, use of mobility aids and access to instrumental support. Design: Cross-sectional. Subjects: A total of 160 persons with prior polio 6-30 months after an individualized, goal-oriented, comprehensive inter-disciplinary rehabilitation programme. Methods: All subjects answered the Swedish version of the Impact on Participation and Autonomy Questionnaire. Results: A majority of the respondents perceived their participation as sufficient in most activities and 65% of the respondents perceived no severe problems with participation. The remaining 35% perceived 1-6 severe problems with participation. All 5 domains of participation were positively correlated with the 9 items for problem experience. Most restrictions in participation were reported in the domains of Family role, Autonomy outdoors, and Work and education. Insufficient instrumental support was most strongly associated with the perception of severe problems with participation. Conclusion: Rehabilitation programmes for persons with late effects of polio need to focus on areas of participation that are perceived as a problem by these persons and to promote access to a supportive environment to enhance their participation.
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