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Sökning: LAR1:lu > Övrigt vetenskapligt/konstnärligt > Umeå universitet

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  • Aylott, Nicholas, et al. (författare)
  • Politiska partier
  • 2005
  • Ingår i: EU och Sverige. - Lund : Studentlitteratur. - 9147075635 ; , s. 58-78
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
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  • Bedke, Jens, et al. (författare)
  • The 2021 Updated European Association of Urology Guidelines on Renal Cell Carcinoma : Immune Checkpoint Inhibitor–based Combination Therapies for Treatment-naive Metastatic Clear-cell Renal Cell Carcinoma Are Standard of Care
  • 2021
  • Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 80:4, s. 393-397
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib plus pembrolizumab over sunitinib. The CheckMate-9ER trial update demonstrated an ongoing PFS, OS, and quality-of-life benefit for cabozantinib plus nivolumab over sunitinib as did the update of Keynote-426 for axitinib plus pembrolizumab in the intention-to-treat population, with a PFS benefit seen across all International Metastatic Database Consortium (IMDC) subgroups. In the IMDC intermediate- and poor-risk groups, the CheckMate-214 trial of ipilimumab plus nivolumab confirmed the OS benefit with a PFS plateauing after 30 months. The RCC Guidelines Panel recommends three tyrosine kinase inhibitors + ICI combinations of axitinib plus pembrolizumab, cabozantinib plus nivolumab, and lenvatinib plus pembrolizumab across all IMDC risk groups in advanced first-line RCC, and dual immunotherapy of ipilimumab and nivolumab in IMDC intermediate- and poor-risk groups. Patient summary: New data from combination trials with immune checkpoint inhibitors for advanced kidney cancer confirm a survival benefit for lenvatinib plus pembrolizumab, cabozantinib plus nivolumab (with improved quality-of-life), axitinib plus pembrolizumab, and ipilimumab plus nivolumab. These combination therapies are recommended as first-line treatment for advanced kidney cancer.
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  • Bergmark, Magnus, et al. (författare)
  • Complex Interventions and Interorganisational Relationships : Examining Core Implementation Components of Assertive Community Treatment
  • 2018
  • Ingår i: International Journal of Integrated Care. - : Ubiquity Press. - 1568-4156 .- 1568-4156. ; 18:4, s. 1-11
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Introduction: There is increasing interest in implementing evidence-based integrated models of care in community-based mental health service systems. Assertive Community Treatment (ACT) is seen as an attractive, and at the same time challenging, model to implement in sectored service settings. This study investigates the implementation process of such an initiative.Methods: Interviews were conducted with ACT team members, the process leader, steering group members, and collaboration partners. The “Sustainable Implementation Scale” helped to identify critical implementation components, and these were further explored using the qualitative interview data. The “Tool for Measuring Assertive Community Treatment” addressed programme fidelity, and the initiative’s sustainability was assessed.Results: High-fidelity implementation of ACT in a sectored service setting is possible. Prominent components that facilitated implementation were careful preparations, team members’ characteristics, and efforts by the process leader and the steering group to improve networking. Implementation was hampered by conflicting goals among the involved authorities and a mismatch between the ACT model’s characteristics and existing organisational traditions and regulations.Discussion and Conclusions: Reducing the uncertainty caused by conflicting goals is an important step in improving the implementation of ACT. In order to facilitate implementation, the goals, regulations, and availability of resources should be aligned horizontally and vertically through the involved organisations.
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  • Bjursten, Henrik, et al. (författare)
  • Reply to Schäfers
  • 2023
  • Ingår i: Interdisciplinary cardiovascular and thoracic surgery. - : Oxford University Press. - 2753-670X .- 1569-9285. ; 36:5
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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