| 1. |
- Antoniou, A. C., et al.
(författare)
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Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers : Implications for risk prediction
- 2010
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Ingår i: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 70:23, s. 9742-9754
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Tidskriftsartikel (refereegranskat)abstract
- The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. We evaluated the associations of 3 additional single nucleotide polymorphisms (SNPs), rs4973768 in SLC4A7/NEK10, rs6504950 in STXBP4/COX11, and rs10941679 at 5p12, and reanalyzed the previous associations using additional carriers in a sample of 12,525 BRCA1 and 7,409 BRCA2 carriers. Additionally, we investigated potential interactions between SNPs and assessed the implications for risk prediction. The minor alleles of rs4973768 and rs10941679 were associated with increased breast cancer risk for BRCA2 carriers (per-allele HR = 1.10, 95% CI: 1.03-1.18, P = 0.006 and HR = 1.09, 95% CI: 1.01-1.19, P = 0.03, respectively). Neither SNP was associated with breast cancer risk for BRCA1 carriers, and rs6504950 was not associated with breast cancer for either BRCA1 or BRCA2 carriers. Of the 9 polymorphisms investigated, 7 were associated with breast cancer for BRCA2 carriers (FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, P = 7 × 10-11 - 0.03), but only TOX3 and 2q35 were associated with the risk for BRCA1 carriers (P = 0.0049, 0.03, respectively). All risk-associated polymorphisms appear to interact multiplicatively on breast cancer risk for mutation carriers. Based on the joint genotype distribution of the 7 risk-associated SNPs in BRCA2 mutation carriers, the 5% of BRCA2 carriers at highest risk (i.e., between 95th and 100th percentiles) were predicted to have a probability between 80% and 96% of developing breast cancer by age 80, compared with 42% to 50% for the 5% of carriers at lowest risk. Our findings indicated that these risk differences might be sufficient to influence the clinical management of mutation carriers.
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| 2. |
- Berndt, Adele, 1966-, et al.
(författare)
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Player and spectator engagement and co-creation in e-sports gaming events during and post-COVID-19
- 2024
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Ingår i: Brand co-creation tourism research. - : Apple Academic Press. - 9781774912515 - 9781774912522 - 9781000778960 - 9781003336228 ; , s. 139-158
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Bokkapitel (refereegranskat)abstract
- Events, occasions on which people gather for a particular purpose, represent a well-established tourism-based distribution channel. Given recent technological advances, virtual tourism events offer a growing platform. As a particular virtual tourism event subtype, e-sports gaming events are online sports-based video-gaming competitions. During COVID-19, the number of e-sports game players and -spectators globally has grown, particularly through lockdown. However, despite this growth, literature-based insight into player- and spectator engagement with e-sports gaming events and their ensuing co-creation lags behind, revealing an important research gap, as explored in this chapter. Based on this gap, we develop a social presence theory-informed model that depicts the effect of e-sports gaming event-perceived intimacy, immediacy, nonverbal communication, and efficiency on player- and spectator engagement and its ensuing impact on e-sports event-perceived co-creation during the pandemic. We conclude with an overview of implications that arise from our work.
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| 3. |
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| 4. |
- Evansluong, Quang, 1984, et al.
(författare)
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From breaking-ice to breaking-out: integration as an opportunity creation process
- 2019
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Ingår i: International Journal of Entrepreneurial Behaviour & Research. - : Emerald Group Publishing Limited. - 1355-2554 .- 1758-6534. ; 25:5, s. 880-899
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – The purpose of this paper is to conduct an inductive case study to understand how the opportunity creation process leads to integration. Design/methodology/approach – It examines four cases of immigrant entrepreneurs of Cameroonian, Lebanese, Mexican and Assyrian origins who founded their businesses in Sweden. The study relies on process-oriented theory building and develops an inductive model of integration as an opportunity creation process. Findings – The suggested model shows immigrants’ acculturation into the host society via three successive phases: breaking-ice, breaking-in and breaking-out. In the breaking-ice phase, immigrants trigger entrepreneurial ideas to overcome the disadvantages that they face as immigrants in the host country. In the breaking-in phase, immigrants articulate their entrepreneurial ideas by bonding with the ethnic community. In the breaking-out phase, the immigrants reorient their entrepreneurial ideas by desegregating them locally.The paper concludes by elaborating theoretical and practical implications of the research. Originality/value – Immigrants act when they are socially excluded and discriminated in the labor market by developing business ideas and becoming entrepreneurs. By practicing the new language and accommodating native customers’ preferences, immigrants reorient their entrepreneurial ideas. The immigrants tailor their ideas to suit their new customers by strengthening their sense of belonging to the local community.
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| 5. |
- Evansluong, Quang V. D.
(författare)
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Opportunity creation as a mixed embedding process : A study of immigrant entrepreneurs in Sweden
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Entrepreneurial opportunities are frequently noted and addressed in the literature of immigrant entrepreneurship; however, little is known about how these entrepreneurial opportunities come into existence and how immigrant entrepreneurs create such opportunities. The purpose of this thesis is to examine why and how immigrant entrepreneurs create entrepreneurial opportunities through embedding processes in the home country and the host country.Sweden was chosen as the country of residence of immigrant entrepreneurs from Lebanon, Syria, Cameroon and Mexico. Four cases were selected in this study. Each case illustrates an opportunity creation process in a different industry, between a different home country and Sweden as the host country and by immigrant entrepreneurs with different backgrounds.By using the mixed embeddedness perspective as the theoretical lens in combination with the literature on entrepreneurial opportunity and immigrant entrepreneurship, this thesis develops a model of entrepreneurial opportunity creation as an integration process. The findings suggest that entrepreneurial opportunity creation can be considered as a process of local integration by immigrant entrepreneurs into the host country and a re-integration of these entrepreneurs into the home country. At the beginning of the opportunity creation process, immigrant entrepreneurs feel socially excluded in the host country. Throughout the opportunity creation process, immigrant entrepreneurs interact with different actors in the host country and gradually move from being socially excluded to socially included, which illustrates a local integration process. In this process, immigrant entrepreneurs become localized through different activities that embed them in the local context. The process of entrepreneurial idea and business concept development and the refinement of the business concept in this thesis illustrates an ongoing and non-linear process of: being locally integrated through creating trust in the local people, acculturating and creating a sense of belonging; and being re-integrated to the home country through maintaining and establishing new links to the home country.The study contributes to the mainstream entrepreneurship and immigrant entrepreneurship in several ways. First, it contributes to studies on immigrant entrepreneurship by investigating why immigrants embark on a journey to be entrepreneurs and how immigrant entrepreneurs create entrepreneurial opportunities through embedding processes in the home and the host country. The study demonstrates how an entrepreneurial opportunity is created as a social integration process.Second, the study contributes to literature on entrepreneurship and immigrant entrepreneurship by incorporating the entrepreneurial opportunity creation process with acculturation strategies. It illustrates how the entrepreneurial opportunity creation process intertwines with the four strategies of acculturation.Third, the study contributes to the mixed embeddedness perspective by adopting the process approach and proposing mixed embedding as a new concept which centers on the interplay between the home and the host country’s influences on immigrants’ business activities; by extending mixed embeddedness from the national level of the home country or the host country to the transnational level between the home country and the host country; and by proposing an alternative way to view an entrepreneurial opportunity as a creation process instead of being discovered.Fourth, the study contributes to the immigrant entrepreneurship literature in Sweden by furthering the understanding of entrepreneurial opportunity creation by immigrant entrepreneurs in Sweden.Furthermore, the study suggests some implications for practice. The study proposes some embedding mechanisms which can be implemented in business support programs for immigrant entrepreneurs and in integration programs for immigrants in general. The design of the business support programs can aim to help immigrant entrepreneurs to: create credibility through contacts and experiences that they establish and gain in the local community; create familiarity to the local community through associating business concepts with well-known values; engage in the local life to understand customers’ mindsets, master the local language to understand local customers’ needs; and establish new/strengthen connections to the home country. The design of integration programs can aim to undertake activities that help immigrants increase the interaction between the local people and themselves. This type of interaction could be increased by organizing meetings and activities in which immigrants are introduced to different local sports clubs and hobby clubs. An approach in which the host country’s language is practiced and mastered anywhere and anytime should be adopted in the integration programs.
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| 6. |
- Hergens, Maria-Pia, et al.
(författare)
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Use of Scandinavian Moist Smokeless Tobacco (Snus) and the Risk of Atrial Fibrillation
- 2014
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Ingår i: Epidemiology. - 1044-3983 .- 1531-5487. ; 25:6, s. 872-876
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Snus is a smokeless tobacco product, widely used among Swedish men and increasingly so elsewhere. There is debate as to whether snus is an acceptable "harm-reduction" tobacco product. Since snus use delivers a dose of nicotine equivalent to cigarettes, and has been implicated in cardiac arrhythmia because of associations with sudden cardiovascular death, a relation with atrial fibrillation is plausible and important to investigate.METHODS:: To assess the relation between use of snus and risk of atrial fibrillation, we carried out a pooled analysis of 7 prospective Swedish cohort studies. In total, 274,882 men, recruited between 1978 and 2004, were followed via the National Patient Register for atrial fibrillation. Primary analyses were restricted to 127,907 never-smokers. Relative risks were estimated using Cox proportional hazard regression.RESULTS:: The prevalence of snus use was 25% among never-smokers. During follow-up, 3,069 cases of atrial fibrillation were identified. The pooled relative risk of atrial fibrillation was 1.07 (95% confidence interval = 0.97-1.19) in current snus users, compared with nonusers.CONCLUSION:: Findings from this large national pooling project indicate that snus use is unlikely to confer any important increase in risk of atrial fibrillation.
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| 7. |
- Kristofferzon, Marja-Leena, 1950-, et al.
(författare)
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Evaluation of a Swedish version of the Watts Sexual Function Questionnaire (WSFQ) in persons with heart disease: A pilot study
- 2010
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Ingår i: European Journal of Cardiovascular Nursing. - Amsterdam : Elsevier. - 1474-5151 .- 1873-1953. ; 9:3, s. 168-174
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Tidskriftsartikel (refereegranskat)abstract
- Background: As part of preparation for a Swedish multicentre study, exploring sexual and married life in patients with myocardial infarction and their partners, a Swedish validated instrument was required. Aims:The aim of this pilot study was to evaluate the validity and reliability of a Swedish version of the Watts Sexual Function Questionnaire (WSFQ) among persons with a heart disease.Methods:A convenience sample of 79 persons (47 men and 32 women) living with a heart disease was recruited from the members of the National Association of Heart and Lung Patients. They completed a Swedish version of the WSFQ on two occasions. Results:Two separate factor analyses each revealed a two-factor structure on both occasions: “Sexual appetite” and “Sexual expectations ”with gender-neutral questions and “Sexual sensitiveness” and “Sexual ability” with gender-specific questions. Cronbach's alpha coefficients ranged from 0.48 to 0.86 and test – retest values for all but one question exceeded 0.70.Conclusions:The Swedish version of the WSFQ showed good validity and stability and acceptable internal homogeneity. Extended evaluations of the questionnaire are recommended.
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| 8. |
- Lopez-Vega, Henry, et al.
(författare)
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Digital transformation of the automotive industry : an integrating framework to analyse technological novelty and breadth
- 2023
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Ingår i: Industry and Innovation. - : Routledge. - 1366-2716 .- 1469-8390. ; 30:1, s. 67-102
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Tidskriftsartikel (refereegranskat)abstract
- Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadth (spanning from one sector to multiple sectors) of digital technologies is important for measuring their impact on industrial transformation. Through a topic modelling research approach on autonomous vehicle technology patents from firms operating in Sweden and a confirmatory survey with the inventors of those patents, this paper reveals 26 digital technology topics that are transforming the automotive industry. The digital technology topics are distributed across four ideal-typical technology categories for transformation: augmenting, spanning, transforming, and disrupting. This study illustrates the value of studying digital technologies’ transformative nature using an integrating framework; it reveals that digital technologies in the automotive industry have mainly incremental characteristics but that these characteristics provide necessary preconditions for the few more radical technologies to achieve their potential in transforming the industry.
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| 9. |
- Molin, Lena, et al.
(författare)
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Do personal experiences have an impact on teaching and didactic choices in geography?
- 2015
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Ingår i: European Journal of Geography. - : Association of European Geographers. - 1792-1341. ; 6:4, s. 6-20
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Tidskriftsartikel (refereegranskat)abstract
- Factors influencing teachers’ selection of content in geography teaching is a fundamental didactic matter.1 The purpose of the present study was to investigate whether Swedish geography teachers’ informal and formal experiences have influenced their interest in geography and if so, in what way. The results disclosed that informal experiences like outings, holidays, and childhood memories have a significant impact. The results also revealed that childhood experiences might increase the comprehension of how nature and mankind are connected, and how various places differ. Selective traditions showed to be strong, i.e. geographic names and map reading were prioritized while at excursions, physical geography was particularly dominating. We argue that in the geography teacher education, didactics should include methods for field studies, giving emphasis also to the part dealing with human geography. Forthcoming teachers need to reflect on how to make didactic choices in order to renounce the selective traditions in the subject.
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| 10. |
- Ohlsson, Ann-Christine, et al.
(författare)
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Potential Risk Factors and Prevalence of Voice Symptoms in Students Starting Their Teacher Education
- 2021
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Ingår i: Journal of Voice. - : Elsevier BV. - 0892-1997 .- 1873-4588. ; 35:2, s. 1-323
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to determine prevalence of voice problems and potential risk factors in teacher students at the start of their education. A total of 1494 students from seven teacher education schools participated in the study. The students answered a questionnaire about 11 risk factors, and one with six questions about voice symptoms, Screen6, and 30 statements in the Voice Handicap Index (VHI). Students reporting at least 2 weekly voice symptoms in Screen6 were assigned to the group with voice problems. Significance level was P < 0.05. Results: prevalence of risk factors was about the same in the seven groups of teacher students except the group with highest proportion of women that also showed the highest proportion of voice problems, 38%. Prevalence of voice problems in the total group was 17%. Comparison of students with or without voice problems showed that all factors except one were more prevalent among students with voice problems and women were overrepresented. Mean total VHI score was 22 in students with voice problems and eight in students without voice problems. Multiple regression analyses showed that frequent throat infections, hearing problems, previous speech therapy, or voice training were the potential risk factors that had the strongest association with voice symptoms as well as with total score in VHI. Conclusions: results from this study show that it is common that teacher students experience voice problems already at the start of their education and potential risk factors associated with voice problems are identified. Knowing that teaching is a high-risk profession for developing voice disorders, it is crucial that teacher students should receive compulsory preprofessional voice education including voice ergonomics and voice training.
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