| 1. |
- Abdulle, Assyr, et al.
(författare)
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Exponential decay of the resonance error in numerical homogenization via parabolic and elliptic cell problems
- 2019
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Ingår i: Comptes rendus. Mathematique. - : Elsevier BV. - 1631-073X .- 1778-3569. ; 357:6, s. 545-551
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents two new approaches for finding the homogenized coefficients of multiscale elliptic PDEs. Standard approaches for computing the homogenized coefficients suffer from the so-called resonance error, originating from a mismatch between the true and the computational boundary conditions. Our new methods, based on solutions of parabolic and elliptic cell problems, result in an exponential decay of the resonance error.
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| 2. |
- Appelbaum, Robert, 1952-
(författare)
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The Looking Glass
- 2016
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Annan publikation (refereegranskat)
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| 3. |
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Cold Heat
- 2011
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Konstnärligt arbete (refereegranskat)
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| 4. |
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Compassion Embodied Toolbox
- 2019
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Konstnärligt arbete (refereegranskat)abstract
- Compassion embodied toolboxHow could we develop compassion embodied skills in our work places, in a more practical manner? This workshop will introduce you to five different tools focusing on embodied compassion.1) Taking care of individual and organizational wellbeing, physically and mentally. 2) Bringing holistic, cultural, artistic elements to the workplace.3) Practicing cultural embodied exercises together. 4) Being aware of the power of emotions at work – abilities and inabilities. 5) Paying attention to the spatial structures as well as the inspirational aesthetic quality of the working spac.e
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| 5. |
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Cover Feature : Analysis of Anion Binding Effects on the Sensitized Luminescence of Macrocyclic Europium(III) Complexes (Anal. Sens. 6/2022)
- 2022
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Ingår i: Analysis & Sensing. - : John Wiley & Sons. - 2629-2742 .- 2629-2742.
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Konstnärligt arbete (refereegranskat)abstract
- The cover feature image represents the differences in the luminescence response upon fluoride vs cyanide binding to a 1,4,7-triazacyclonane-based Eu(III) complex equipped with a carbostyril light-harvesting antenna. The addition of excess of fluoride boosts the Eu(III) emission quantum yield by up to 6-fold for such compounds. Cyanide addition extinguishes Eu(III) luminescence despite partial anion binding to a lanthanide 3+ ion. These compounds showed opposite responses upon fluoride and cyanide binding, and the results could facilitate the design of responsive probes for multiple anion types. More information can be found in the Research Article (https://doi.org/10.1002/anse.202200015) by K. E. Borbas and co-workers.
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| 6. |
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| 7. |
- Gu, Gucci Jijuan, 1984-, et al.
(författare)
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Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease
- 2013
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 33:3, s. 699-713
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Tidskriftsartikel (refereegranskat)abstract
- The appearance of neurofibrillary tangles (NFT), one of the major hallmarks of Alzheimer's disease (AD), is most likely caused by inappropriate phosphorylation and/or dephosphorylation of tau, eventually leading to the accumulation of NFTs. Enhanced phosphorylation of tau on Ser(262) is detected early in the course of the disease and may have a role in the formation of tangles. Several kinases such as microtubule-affinity regulating kinase (MARK), protein kinase A, calcium calmodulin kinase II, and checkpoint kinase 2 are known to phosphorylate tau on Ser(262) in vitro. In this study, we took advantage of the in situ proximity ligation assay to investigate the role of MARK2, one of the four MARK isoforms, in AD. We demonstrate that MARK2 interacts with tau and phosphorylates tau at Ser(262) in stably transfected NIH/3T3 cells expressing human recombinant tau. Staurosporine, a protein kinase inhibitor, significantly reduced the interaction between MARK2 and tau, and also phosphorylation of tau at Ser(262). Furthermore, we observed elevated interactions between MARK2 and tau in post-mortem human AD brains, compared to samples from non-demented elderly controls. Our results from transfected cells demonstrate a specific interaction between MARK2 and tau, as well as MARK2-dependent phosphorylation of tau at Ser(262). Furthermore, the elevated interactions between MARK2 and tau in AD brain sections suggests that MARK2 may play an important role in early phosphorylation of tau in AD, possibly qualifying as a therapeutic target for intervention to prevent disease progression.
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| 8. |
- Haque, Rehnuma, et al.
(författare)
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Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh : approach to complement public health surveillance systems
- 2023
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Ingår i: Human Genomics. - : Springer Nature. - 1473-9542 .- 1479-7364. ; 17
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundWastewater-based epidemiological surveillance has been considered a powerful tool for early detection and monitoring of the dynamics of SARS-CoV-2 and its lineages circulating in a community. This study is aimed to investigate the complexity of SARS-CoV-2 infection dynamics in Dhaka city by examining its genetic variants in wastewater. Also, the study seeks to determine a connection between the SARS-CoV-2 variations detected in clinical testing and those found in wastewater samples.ResultsOut of 504 samples tested in RT-qPCR, 185 (36.7%) tested positive for SARS-CoV-2 viral RNA. The median log10 concentration of SARS-CoV-2 N gene copies/Liter of wastewater (gc/L) was 5.2, and the median log10 concentration of ORF1ab was 4.9. To further reveal the genetic diversity of SARS-CoV-2, ten samples with ORF1ab real-time RT-PCR cycle threshold (Ct) values ranging from 28.78 to 32.13 were subjected to whole genome sequencing using nanopore technology. According to clade classification, sequences from wastewater samples were grouped into 4 clades: 20A, 20B, 21A, 21J, and the Pango lineage, B.1, B.1.1, B.1.1.25, and B.1.617.2, with coverage ranging from 94.2 to 99.8%. Of them, 70% belonged to clade 20B, followed by 10% to clade 20A, 21A, and 21J. Lineage B.1.1.25 was predominant in Bangladesh and phylogenetically related to the sequences from India, the USA, Canada, the UK, and Italy. The Delta variant (B.1.617.2) was first identified in clinical samples at the beginning of May 2021. In contrast, we found that it was circulating in the community and was detected in wastewater in September 2020.ConclusionEnvironmental surveillance is useful for monitoring temporal and spatial trends of existing and emerging infectious diseases and supports evidence-based public health measures. The findings of this study supported the use of wastewater-based epidemiology and provided the baseline data for the dynamics of SARS-CoV-2 variants in the wastewater environment in Dhaka, Bangladesh.
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| 9. |
- Hrynczenko, Iwona, et al.
(författare)
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Shadow dance : Installation and discussion on proposed solutions for embodied games through cross-disciplinary workshops within an educational context
- 2010
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Konferensbidrag (refereegranskat)abstract
- This paper argues the issue of embodiment and gesture in games, the aesthetics of movement from the phenomenological point of view, and suggests a framework proposal for DAMA, a Dance and Media Art Network interdisciplinary network project, which integrates students and teachers from art schools and universities within the European Nordic and Baltic regions. This argument is supported by documentation of Shadow Dance installation that presents an interactive tool for corporal expressions, based on real-time movement capture, an open source and visual programming environment (Pure Data), all integrated within a web environment. The aim of this installation is to propose a different perspective based on corporal movement’s aesthetics via subjective expressions. It is one of the action points for the game development process, during interdisciplinary workshops, proposing content based on traditions in dance and physical theatre and encouraging the notions of presence and creative use of whole body movements across digital space and especially within physical games.
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| 10. |
- Kaur, Amanpreet, et al.
(författare)
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Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- 2023
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Ingår i: Chemical Science. - : Royal Society of Chemistry. - 2041-6520 .- 2041-6539. ; 14:20, s. 5291-5301
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Tidskriftsartikel (refereegranskat)abstract
- Sulfur is an essential element of life. Thiol-containing metabolites in all organisms are involved in the regulation of diverse biological processes. Especially, the microbiome produces bioactive metabolites or biological intermediates of this compound class. The analysis of thiol-containing metabolites is challenging due to the lack of specific tools, making these compounds difficult to investigate selectively. We have now developed a new methodology comprising bicyclobutane for chemoselective and irreversible capturing of this metabolite class. We utilized this new chemical biology tool immobilized onto magnetic beads for the investigation of human plasma, fecal samples, and bacterial cultures. Our mass spectrometric investigation detected a broad range of human, dietary and bacterial thiol-containing metabolites and we even captured the reactive sulfur species cysteine persulfide in both fecal and bacterial samples. The described comprehensive methodology represents a new mass spectrometric strategy for the discovery of bioactive thiol-containing metabolites in humans and the microbiome.
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