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Pain relief followi...
Pain relief following a single-dose intra-articular injection of methylprednisolone in the temporomandibular joint arthralgia-A multicentre randomised controlled trial
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- Isacsson, G. (författare)
- Department of Orofacial Pain and Jaw Function, Västmanland County Hospital, Västerås, Sweden,Vastmanland Cty Hosp, Dept Orofacial Pain & Jaw Funct, Vasteras, Sweden
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- Schumann, M. (författare)
- Department of Orofacial Pain and Jaw Function, Västmanland County Hospital, Västerås, Sweden,Vastmanland Cty Hosp, Dept Orofacial Pain & Jaw Funct, Vasteras, Sweden
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- Nohlert, Eva, 1955- (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Mejersjö, Christina (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Clinic of Orofacial Pain, Sahlgrenska Academy and Public Dental Health, Gothenburg, Sweden
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- Tegelberg, Åke (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Department of Orofacial Pain and Jaw Function, Postgraduate Dental Education Center, Örebro, Sweden,Postgrad Dent Educ Ctr, Dept Orofacial Pain & Jaw Funct, Orebro, Sweden;Malmo Univ, Fac Odontol, Dept Orofacial Pain & Jaw Funct, Malmo, Sweden
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(creator_code:org_t)
- 2018-10-10
- 2019
- Engelska.
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Ingår i: J Oral Rehabil. - : Wiley. - 0305-182X .- 1365-2842. ; 46:1, s. 5-13
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Abstract
Ämnesord
Stäng
- Background Temporomandibular joint (TMJ) arthralgia is a painful condition assumed to be associated with local inflammation. Objective The objective of the present study was to determine the efficacy for reducing pain of a single-dose intra-articular (IA) injection of methylprednisolone to the TMJ. The hypothesis was that methylprednisolone would effectively reduce TMJ pain. Methods This randomised, double-blind, parallel-group, multicentre, controlled study included visits for enrolment, treatment and 4-week follow-up. The study included patients 18 years and older who had been diagnosed with unilateral TMJ arthralgia. All participants were randomly assigned to receive 1 mL IA injections of methylprednisolone or saline. The primary outcome was change in recorded pain intensity on a visual analogue scale (VAS) at maximum jaw opening, analysed in the per protocol population. Results In total, 54 patients were randomly assigned to single-dose IA injections with methylprednisolone (n = 27) or saline (n = 27). Between baseline and the 4-week follow-up, VAS-rated pain intensity at maximum jaw opening decreased from a mean of 61.0 (95% confidence interval [CI]: 50.1; 70.7) to 33.9 (95% CI: 21.6; 46.2) in the methylprednisolone group and from 59.6 (95% CI: 50.7; 65.9) to 33.9 (95% CI: 23.8; 43.9) in the saline group. The between-group difference was not significant (P = 0.812). Treatment-related adverse events were doubled in the methylprednisolone group. Conclusion Methylprednisolone provided no additional benefit for reducing pain, but caused more harm compared with saline following a single-dose IA injection in patients with TMJ arthralgia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- arthralgia
- corticosteroids
- injection
- intra-articular
- pain management
- temporomandibular joint
- clinical importance
- depression
- validity
- Dentistry
- Oral Surgery & Medicine
- arthralgia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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