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| 2. |
- Dumanski, Jan P., et al.
(författare)
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Smoking is associated with mosaic loss of chromosome Y
- 2015
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
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Tidskriftsartikel (refereegranskat)abstract
- Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
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| 3. |
- Grandin, Ulf, et al.
(författare)
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Allozyme variation at a PGI locus in differently aged populations of Moehringia trinervia (Caryophyllaceae) in a successional area
- 2002
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Ingår i: Nordic Journal of Botany. - : Wiley. - 0107-055X .- 1756-1051. ; 22:3, s. 303-311
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Tidskriftsartikel (refereegranskat)abstract
- We studied genetic effects of the colonisation process during primary succession by analysing allozyme variation at a PGI locus in differently aged populations of Moehringia trinervia, which is a selfing annual with low dispersal ability. The populations studied come from islands and shores created in the 1880s by a drop in the water table of a Swedish lake and from old parts of a large island and of the mainland. The population age is known from five vegetation analyses over a century. We have also analysed the genetic composition of M. trinervia derived from seeds in the soil. Mainland populations had a higher genetic diversity than island populations that were little differentiated and differed genetically from the mainland populations. There was no temporal trend in the distribution of genetic variation on the new islands. The presence of alleles in the extant populations was associated with the proportion of that allele in the seed bank, indicating a main recruitment from the seed bank and not by repeated immigrations. We suggest that some of the new islands were colonised by a few early founders from the mainland. Later colonisation has occurred between adjacent islands, which preserves the founder effect and could explain the uniform, low genetic variation in the island populations
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| 4. |
- Gunnarsson, Urban, et al.
(författare)
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Local-scale genetic structure in the peatmoss Sphagnum fuscum
- 2007
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Ingår i: Molecular Ecology. - 0962-1083 .- 1365-294X. ; 16:2, s. 305-312
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Tidskriftsartikel (refereegranskat)abstract
- Sphagnum (peatmoss) dominates huge areas of the Northern Hemisphere and acts as a significant carbon sink on a global scale, yet little is known about the genetic structure of Sphagnum populations. We investigated genetic structure within a population of the common peatmoss Sphagnum fuscum, to assess local patterns of genetic diversity and the spatial extent of clones. One hundred seventeen shoots were sampled from five transects in Fuglmyra, central Norway, and sequenced for three anonymous DNA regions. Five neighbourhood patches were marked along each transect, and from each patch, five stems were sampled for molecular analyses. Seventeen haplotypes could be distinguished and two major groups of haplotypes differed by 12 mutational steps. The two major haplotype groups differed significantly in microhabitat association along the distance to groundwater table and the pH gradients, indicating microhabitat differentiation. The haplotypes within these groups were all genetically similar, differing by one or two mutations. The most common haplotype occurred in four transects separated by 250-m distance. Most of the molecular variation in the population was found among transects, and within patches. Large dominating clones within each transect resulted in low variation explained by the among-patch-within-transect component of spatial structure. Mutation appears to account for a larger proportion of the population variation than recombination. Within the population, vegetative growth and asexual reproduction from gametophyte fragments dominate as the main reproductive mode.
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| 5. |
- Hammarström, Per, 1960-
(författare)
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Nationens styvbarn : Judisk samhällsintegration i några Norrlandsstäder 1870-1940
- 2007
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Ingår i: Svensk kyrkotidning. - Stockholm : Carlsson Bokförlag. - 0346-2153. ; :51-52, s. 664-
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna avhandling är att undersöka vilken ekonomisk och social ställning den judiska minoriteten intog i det svenska samhället under perioden 1870 till 1940. Tidigare forskning har riktat stor uppmärksamhet mot rättsliga och politiska aspekter av den svenska judenhetens historia, mer sällan mot judarna och samhället i en bredare bemärkelse. Andra studier har lyft fram antisemitism på svensk mark utan att koppla fenomenet till en social nivå.Genom en undersökning av hur judiska invandrare, med ursprung i Östeuropa, successivt fogades in i några svenska lokalsamhällen, tar denna avhandling ett bredare grepp på frågan om judarna och samhället. Här undersöks hur den svenska judenheten integrerades i samhället efter det att emancipationen gett judarna fulla medborgerliga och politiska rättigheter. Judarnas ekonomiska och sociala ställning undersöks, liksom den sociala antisemitism som drabbade judarna. Studien rör sig i gränslandet mellan social- och kulturhistoria. Undersökningen visar att merparten av judarna i Sundsvall, en betydelsefull handelsstad i norra Sverige, fick sin försörjning genom en föga lönsam gårdfarihandel under början av undersökningsperioden. Sedan butiks- och grosshandelsrörelser började grundas inleddes en långsam socioekonomisk klättring. I takt med de ekonomiska framgångarna ökade judarnas sociala status, med engagemang i föreningslivet och lokalpolitiken. De framgångsrika familjerna tonade ner sin judiska identitet till förmån för en borgerlig och nationell kultur.Ungefär hälften av den judiska gruppen fick aldrig uppleva framgången utan förblev en marginaliserad grupp, med småhantverk eller gårdfarihandel som försörjningsbas. Det stora flertalet av denna underklass saknade svenskt medborgarskap. En social klyfta vidgades gentemot den judiska borgerligheten. Under hela undersökningsperioden var antisemitismen en kulturell kod i majoritetssamhället, oavsett integration och socioekonomisk framgång. Mycket tyder på att det sociala klimatet blev mer fientligt gentemot judarna efter 1920. Studien visar att nationalstaten Sverige lämnade litet utrymme för multikulturella strukturer. Judarna accepterades som nationens styvbarn men knappast som fullvärdiga svenskar.
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| 6. |
- Jernberg, Signe, 1980-, et al.
(författare)
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Äldreomsorgen i historisk belysning : organisering, politisering, professionalisering
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapportens syfte är att skapa förståelse för äldreomsorgens praktik, styrning och ideologi idag, genom att sätta detta i ett historiskt sammanhang. Vi visar hur styrning och ledning av äldreomsorgen gradvis blir mer abstrakta och hur styrningspraktiken distanseras från den sociala verkligheten. Detta går hand i hand med, och menar vi kanske delvis beror på att, nya mer professionella tjänstemannagrupper, ibland helt utan erfarenhet och utbildning inom äldreomsorgen fått en viktigare roll, samtidigt som kommunpolitiken alltmer partipolitiserats och samtidigt blivit en karriärväg för de ledande partiföreträdarna. Vårt fokus ligger på nutiden, men för att förstå denna går vi tillbaka i äldreomsorgens historia, och beskriver hur äldreomsorgen utformats under olika tider, samt hur det uppstod en kommunal politikerroll som skulle styra äldreomsorgen. Efter det beskriver vi hur de yrkesgrupper som dominerar administration och organisation av äldreomsorgen vuxit fram och utvecklats. Slutligen diskuterar vi konsekvenserna av utvecklingen för äldreomsorgen idag. Rapportens empiriska material bygger på arkivmaterial från Uppsala kommun samt nationella och lokala styrdokument av social omsorg i allmänhet och äldreomsorg i synnerhet.
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| 7. |
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| 8. |
- Lönn, Mikael, et al.
(författare)
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Hybrids and fruit set in a mixed flowering-time population of Gymnadenia conopsea (Orchidaceae)
- 2006
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Ingår i: Hereditas. - : Springer Science and Business Media LLC. - 0018-0661 .- 1601-5223. ; 143:1, s. 222-228
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Tidskriftsartikel (refereegranskat)abstract
- We have recently found that the morphologically determined subspecies Gymnadenia conopsea ssp conopsea in Sweden includes early and late flowering individuals. We were interested in the interactions between the flowering time groups; if there were gene flow between them and if so this was detrimental or advantageous. A spatially mixed population of early and late flowering individuals was studied using three microsatellite loci. We measured patterns in genetic differentiation and inferred occurrence of hybridisation and introgression. Variation in flowering time, fertility and relative and absolute fruit set was measured. The pattern of introgression between flowering-time groups differed between loci. In two of the three investigated loci, allele separation was distinct between early and late flowering plants and one genetically obvious hybrid was infertile. In the third locus, several alleles were shared between the two flowering time variants. The degree of introgression was associated to fruit set failure, which was higher in the late flowering plants and lower in early flowering plants. A small group of early flowering individuals with somewhat delayed flowering compared to the main group was genetically distinct and had lower relative and absolute fruit set. This group was not genetically intermediate, but rather constituting an independent group, with lower fruit set possibly caused by absence of pollinators. There seem to be a strong barrier against introgression into the late flowering group which is kept genetically distinct and less diverse. The early flowering group is diverse, includes two subgroups and seems to benefit from gene flow.
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| 9. |
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| 10. |
- Roos, Lena, 1966-
(författare)
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Anglikanska kyrkan
- 2008
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Ingår i: Religion i Sverige. - Stockholm : Dialogos. - 9789175041995 ; , s. 113-114
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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