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  • Aabel, Peder, et al. (författare)
  • Transcription and microRNA Profiling of Cultured Human Tympanic Membrane Epidermal Keratinocytes
  • 2018
  • Ingår i: Journal of the Association for Research in Otolaryngology. - SPRINGER. - 1525-3961 .- 1438-7573. ; 19:3, s. 243-260
  • Tidskriftsartikel (refereegranskat)abstract
    • The human tympanic membrane (TM) has a thin outer epidermal layer which plays an important role in TM homeostasis and ear health. The specialised cells of the TM epidermis have a different physiology compared to normal skin epidermal keratinocytes, displaying a dynamic and constitutive migration that maintains a clear TM surface and assists in regeneration. Here, we characterise and compare molecular phenotypes in keratinocyte cultures from TM and normal skin. TM keratinocytes were isolated by enzymatic digestion and cultured in vitro. We compared global mRNA and microRNA expression of the cultured cells with that of human epidermal keratinocyte cultures. Genes with either relatively higher or lower expression were analysed further using the biostatistical tools g:Profiler and Ingenuity Pathway Analysis. Approximately 500 genes were found differentially expressed. Gene ontology enrichment and Ingenuity analyses identified cellular migration and closely related biological processes to be the most significant functions of the genes highly expressed in the TM keratinocytes. The genes of low expression showed a marked difference in homeobox (HOX) genes of clusters A and C, giving the TM keratinocytes a strikingly low HOX gene expression profile. An in vitro scratch wound assay showed a more individualised cell movement in cells from the tympanic membrane than normal epidermal keratinocytes. We identified 10 microRNAs with differential expression, several of which can also be linked to regulation of cell migration and expression of HOX genes. Our data provides clues to understanding the specific physiological properties of TM keratinocytes, including candidate genes for constitutive migration, and may thus help focus further research.
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6.
  • Aabloo, A, et al. (författare)
  • Molecular dynamics simulation of Nd3+ ions in a crystalline PEO surface
  • 1998
  • Ingår i: ELECTROCHIMICA ACTA. - 0013-4686. ; 43:10-11, s. 1361-1364
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • Poly(ethylene oxide) based electrolytes are systems in which ionic salts are dissolved into an amorphous EO matrix. Potentials developed earlier to model crystalline and amorphous bulk PEO systems are here used for the MD simulation at 400 K of the behavi
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7.
  • Aabloo, A, et al. (författare)
  • Molecular dynamics simulations of a poly(ethylene oxide) surface
  • 1997
  • Ingår i: POLYMER. - 0032-3861. ; 38:18, s. A47-A51
  • Tidskriftsartikel (refereegranskat)abstract
    • Potentials developed earlier for crystalline and amorphous bulk PEO systems have been used for the MD simulation of a PEO surface model. The surface comprises the outer region of a 122 Angstrom-thick sheet of PEO in which the PEO, -(CH2-CH2-O)(n)- chains
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8.
  • Aaboud, M., et al. (författare)
  • A measurement of the calorimeter response to single hadrons and determination of the jet energy scale uncertainty using LHC Run-1 pp-collision data with the ATLAS detector
  • 2017
  • Ingår i: European Physical Journal C. - 1434-6044. ; 77:1
  • Tidskriftsartikel (refereegranskat)abstract
    • A measurement of the calorimeter response to isolated charged hadrons in the ATLAS detector at the LHC is presented. This measurement is performed with 3.2 nb(-1) of proton-proton collision data at root s = 7 TeV from 2010 and 0.1 nb(-1) of data at root s = 8 TeV from 2012. A number of aspects of the calorimeter response to isolated hadrons are explored. After accounting for energy deposited by neutral particles, there is a 5% discrepancy in the modelling, using various sets of GEANT4 hadronic physics models, of the calorimeter response to isolated charged hadrons in the central calorimeter region. The description of the response to anti-protons at low momenta is found to be improved with respect to previous analyses. The electromagnetic and hadronic calorimeters are also examined separately, and the detector simulation is found to describe the response in the hadronic calorimeter well. The jet energy scale uncertainty and correlations in scale between jets of different momenta and pseudorapidity are derived based on these studies. The uncertainty is 2-5% for jets with transverse momenta above 2 TeV, where this method provides the jet energy scale uncertainty for ATLAS.
9.
  • Aaboud, M, et al. (författare)
  • A search for resonances decaying into a Higgs boson and a new particle X in the XH -> qqbb final state with the ATLAS detector
  • 2018
  • Ingår i: Physics Letters B. - 0370-2693. ; 779, s. 24-45
  • Tidskriftsartikel (refereegranskat)abstract
    • A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb(-1) of proton-proton collision data at root s = 13 TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle Xis assumed to decay to a pair of light quarks, and the fully hadronic final state XH -> q (q) over bar 'b (b) over bar is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the XH -> q (q) over bar 'b (b) over bar resonance.
10.
  • Aaboud, M., et al. (författare)
  • Angular analysis of B-d(0) -> K* mu(+)mu(-) decays in pp collisions at root s=8 TeV with the ATLAS detector
  • 2018
  • Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708. ; :10
  • Tidskriftsartikel (refereegranskat)abstract
    • An angular analysis of the decay B-d(0) -> K*mu(+)mu(-) is presented, based on proton-proton collision data recorded by the ATLAS experiment at the LHC. The study is using 20.3 fb(-1) of integrated luminosity collected during 2012 at centre-of-mass energy of root s = 8TeV. Measurements of the K* longitudinal polarisation fraction and a set of angular parameters obtained for this decay are presented. The results are compatible with the Standard Model predictions.
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