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Sökning: LAR1:uu > Recension > Medicin och hälsovetenskap

  • Resultat 1-10 av 36
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1.
  • Prokunina, Ludmila, et al. (författare)
  • A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
  • 2002
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 32:4, s. 666-669
  • Recension (övrigt vetenskapligt/konstnärligt)abstract
    • Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women. A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified. We previously reported a susceptibility locus (SLEB2) for Nordic multi-case families. Within this locus, the programmed cell death 1 gene (PDCD1, also called PD-1) was considered the strongest candidate for association with the disease. Here, we analyzed 2,510 individuals, including members of five independent sets of families as well as unrelated individuals affected with SLE, for single-nucleotide polymorphisms (SNPs) that we identified in PDCD1. We show that one intronic SNP in PDCD1 is associated with development of SLE in Europeans (found in 12% of affected individuals versus 5% of controls; P = 0.00001, r.r. (relative risk) = 2.6) and Mexicans (found in 7% of affected individuals versus 2% of controls; P = 0.0009, r.r. = 3.5). The associated allele of this SNP alters a binding site for the runt-related transcription factor 1 (RUNX1, also called AML1) located in an intronic enhancer, suggesting a mechanism through which it can contribute to the development of SLE in humans.
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  • Blomberg, Jonas, et al. (författare)
  • Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer
  • 2011
  • Ingår i: Advances in Virology. - : Hindawi Limited. - 1687-8639 .- 1687-8647. ; 2011, s. 341294-
  • Recension (refereegranskat)abstract
    • Gammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine retrovirus related virus (XMRV) and Human Mouse retrovirus-like RetroViruses (HMRVs)) reported from patients suffering from prostate cancer (PC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) raise the possibility that also humans have been infected. Structurally intact, potentially infectious MLLVs occur in the genomes of some mammals, especially mouse. Mouse MLLVs contain three major groups. One, MERV G3, contained MLVs and XMRV/HMRV. Its presence in mouse DNA, and the abundance of xenotropic MLVs in biologicals, is a source of false positivity. Theoretically, XMRV/HMRV could be one of several MLLV transspecies infections. MLLV pathobiology and diversity indicate optimal strategies for investigating XMRV/HMRV in humans and raise ethical concerns. The alternatives that XMRV/HMRV may give a hard-to-detect "stealth" infection, or that XMRV/HMRV never reached humans, have to be considered.
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  • Abrahamsson, Lillemor, et al. (författare)
  • Principles of nutritional assessment
  • 2006
  • Ingår i: Scandinavian Journal of Food and Nutrition. - 1748-2976 .- 1748-2984. ; 50:4, s. 177-177
  • Recension (populärvet., debatt m.m.)
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8.
  • Andersson, Dan, et al. (författare)
  • Antibiotikaresistens: är den reversibel?
  • 1998
  • Ingår i: Smittskydd: Smittskyddsinstitutets tidskrift. - 1401-0690. ; 4:1, s. 3-5
  • Recension (övrigt vetenskapligt/konstnärligt)
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  • Andersson, D. I., Björkman, J. and Hughes, D. (författare)
  • Fitness and virulence of antibiotic resistant bacteria.
  • 2001
  • Ingår i: Antibiotic Development and Resistance.. - : Taylor and Francis Publishers, London and New York. - 0415272173 ; , s. 155-162
  • Recension (övrigt vetenskapligt/konstnärligt)
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