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- Alm, Albert
(författare)
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Effects of norepinephrine, angiotensin, dihydroergotamine, papaverine, isoproterenol, histamine, nicotinic acid, and xanthinol nicotinate on retinal oxygen tension in cats
- 1972
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Ingår i: Acta Ophthalmologica. - : Wiley. - 0001-639X .- 1755-375X. ; 50:5, s. 707-719
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Tidskriftsartikel (refereegranskat)abstract
- The oxygen tension in the vitreous body close to the retina, PvrO2, was determined continuously in cats. The effects on PvrO2 of intraarterial injections of various vasoactive drugs were determined. The vasoconstrictors norepinephrine, angiotensin and dihydroergotamine did not change PvrO2 in five cats. The same result was obtained with the vasodilators isoproterenol, histamine and xanthinol nicotinate in five cats, and with nicotinic acid in six cats, while papaverine invariably increased PvrO2 in seven cats when injected intraarterially and in two cats when injected intravenously. It is suggested that the ability to penetrate the blood-retinal barrier may play an important role in determining the effect of vaso-active drugs on retinal blood flow.
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- Alm, Gunnar V., et al.
(författare)
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The in vitro maturation of the embryonic chicken thymus, 1: : Development of an Organ Culture System
- 1972
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Ingår i: Acta Pathologica Microbiologica Scandinavica, Section A Pathology. - : Wiley. - 0365-4184. ; A 80:6, s. 778-784
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Tidskriftsartikel (refereegranskat)abstract
- An organ culture technique is described which permits the lymphoid development of the thymic anlagen of 10-day-old chick embryos for at least 10 days in vitro. Grid organ cultures of a modified Trowell type were employed. Among several tissue culture media tested, Waymouth's MB 752/1 medium gave superior results. In initial experiments this medium was supplemented with heat-inactivated horse serum and embryo-extract. Subsequently it was found that this supplement could be substituted for by chicken serum alone. The morphological development of the embryonic thymic anlagen in organ culture has been characterized. Typical lymphoid cells developed from the initial lymphoid precursor cells. Late in the culture period, large numbers of small lymphocytes appeared. Extensive cell proliferation was demonstrated during the first 6 days of culture by means of autoradiography. This organ culture technique should facilitate the further analysis of factors influencing thymic lymphocytopoiesis as well as of the role of the thymus in the development of lymphocyte functions.
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