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- Ahrne, Göran
(författare)
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Delvis människa, delvis organisation
- 1993
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Ingår i: Sociologisk forskning. - : Sveriges Sociologförbund. - 0038-0342 .- 2002-066X. ; 30:1, s. 59-78
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Tidskriftsartikel (refereegranskat)abstract
- Partly human, partly organizationIn this article the phenomenon of organization is discussed and its consequences for the understanding of human actions and human choices are examined. Affiliation to organizations are found to be both restrictions on and preconditions for most human action. In this connection families are regarded as organizations as well as enterprises, voluntary associations and states. Human action is primarily action on behalf of organizations where individuals are partly human, partly organization. To understand the meaning of action on behalf of organization it is important to realize that people rarely choose their organizational affiliation. People are selected. This means that actions on behalf of organizations cannot be regarded as expressions of individual choices. Actions on behalf of organizations are generally characterized by a dual involvement.
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- Emahazion, Tesfai, et al.
(författare)
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Identification of 167 Polymorphisms in 88 Genes from Candidate Neurodegeneration Pathways
- 1999
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Ingår i: Gene. - 0378-1119 .- 1879-0038. ; 238:2, s. 315-324
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Tidskriftsartikel (refereegranskat)abstract
- Catalogs of intra-gene polymorphisms are needed to facilitate wide-ranging candidate gene-based association studies in common complex diseases. With this in mind, we have scanned multiple alignments of expressed sequence tags and of genomic DNA sequences (PCR products from four to eight unrelated individuals) to find polymorphisms in 195 genes putatively involved in neurodegenerative illness (including components of oxidative stress, excitotoxicity, inflammation, apoptosis and aging). This led to the discovery of 167 polymorphisms in 88 genes. These comprised 163 single nucleotide polymorphisms, one insertion/deletion, and three other variations involving more than one base pair. The polymorphisms were distributed in the exons (87), introns (70), and gene flanking regions (10). Of the exonic polymorphisms, 17 would give rise to non-synonymous amino acid substitutions. These findings now provide a valuable resource for association studies in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.
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- Gilsenan Nordin, Irene
(författare)
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Crediting marvels in Seamus Heaney's Seeing things
- 1999
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This is a study of the Irish, Nobel prize-winning poet Seamus Heaney's Seeing Things, (1991), a volume which marks a turning point in Heaney's writing. From an earlier concern with the outer physicality of things, Heaney turns with deepened awareness to the inner landscapes of the mind, where the thingness of things is explored and expressed in language. The dissertation examines this new departure in the light of what Heidegger terms a call to "primordial authenticity," which is uncovered in the everydayness of things and given voice in the poetic utterance. The focus of this thesis differs from previous scholarship in that it sets out to make a detailed analysis of the whole volume of Seeing Things and takes as its starting point a Heideggerian approach, where the basic concept of "being-in-the-world" is understood in terms of the belonging together of self and world. I examine how this interrelation manifests itself in Heaney's poetry. Heidegger rejects the transcendental subject as a starting point, and begins instead from an understanding of the immanent "givenness" of human existence. These ideas are thus used to explore the poetry of Seeing Things. In addition to Heidegger, this study is also influenced by the writings of Hans-Georg Gadamer. Gadamer's theoretical approach with its concern for what he calls the "fusion of horizons", is especially useful in studying Heaney's poetry, where a strong sense of dialectic movement is evident between opposing forces. Using these ideas of Heidegger and Gadamer, I trace a thematic Dantean quest for understanding in Seeing Things, and explore how, in the context of this journey, thresholds are crossed in a constant Heraclitean flow between the forces of fixity and flux. The study also traces various other binaries, such as absence and presence, speech and silence, which are part of our experience of being-in-the-world. I show how these oppositions are brought together in a poetics of understanding. Such experiences of awareness are seen as moments of epiphany, or what Gadamer calls "a shattering and demolition of the familiar." Thus, central to this study is an understanding of the mystery and power of language, and of how poetry acts as a transforming vision of reality, or in the Heideggerian sense, as a proclamation of the holy that takes the "mysterious measure" of things.
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