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| 2. |
- de Graaf, Albert A, et al.
(författare)
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Nutritional systems biology modeling: from molecular mechanisms to physiology.
- 2009
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Ingår i: PLoS computational biology. - : Public Library of Science (PLoS). - 1553-7358 .- 1553-734X. ; 5:11
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Forskningsöversikt (refereegranskat)abstract
- The use of computational modeling and simulation has increased in many biological fields, but despite their potential these techniques are only marginally applied in nutritional sciences. Nevertheless, recent applications of modeling have been instrumental in answering important nutritional questions from the cellular up to the physiological levels. Capturing the complexity of today's important nutritional research questions poses a challenge for modeling to become truly integrative in the consideration and interpretation of experimental data at widely differing scales of space and time. In this review, we discuss a selection of available modeling approaches and applications relevant for nutrition. We then put these models into perspective by categorizing them according to their space and time domain. Through this categorization process, we identified a dearth of models that consider processes occurring between the microscopic and macroscopic scale. We propose a "middle-out" strategy to develop the required full-scale, multilevel computational models. Exhaustive and accurate phenotyping, the use of the virtual patient concept, and the development of biomarkers from "-omics" signatures are identified as key elements of a successful systems biology modeling approach in nutrition research--one that integrates physiological mechanisms and data at multiple space and time scales.
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| 3. |
- Edvardsson, David, et al.
(författare)
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Fysisk och psykosocial miljö
- 2009
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Ingår i: Socialstyrelsens Nationella riktlinjer för vård och omsorg om personer med demenssjukdom. Preliiminär version.
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Forskningsöversikt (refereegranskat)
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| 4. |
- Hohmann, Stefan, 1956
(författare)
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Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae.
- 2009
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Ingår i: FEBS letters. - : Wiley. - 1873-3468 .- 0014-5793. ; 583:24, s. 4025-9
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Forskningsöversikt (refereegranskat)abstract
- Signal transduction pathways control cellular responses to extrinsic and intrinsic signals. The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation to hyperosmotic stress. Pathway architecture as well as the flow of signal have been studied to a very high degree of detail. Recently, the yeast HOG pathway has become a popular model to analyse systems level properties of signal transduction. Those studies addressed, using experimentation and modelling, the role of basal signalling, robustness against perturbation, as well as adaptation and feedback control. These recent findings provide exciting insight into the higher control levels of signalling through this MAPK system of potential general importance.
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| 5. |
- Shekhter, Robert I., 1947, et al.
(författare)
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Nonequilibrium and quantum coherent phenomena in the electromechanics of suspended nanowires
- 2009
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Ingår i: Low Temperature Physics. - : AIP Publishing. - 1090-6517 .- 1063-777X. ; 35:8
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Forskningsöversikt (refereegranskat)abstract
- Strong coupling between electronic and mechanical degrees of freedom is a basic requirement for the operation of any nanoelectromechanical device. In this Review we consider such devices and in particular investigate the properties of small tunnel-junction nanostructures that contain a movable element in the form of a suspended nanowire. In these systems, electrical currents and charge can be concentrated to small spatial volumes resulting in strong coupling between the mechanics and the charge transport. As a result, a variety of mesoscopic phenomena appear, which can be used for the transduction of electrical currents into mechanical operation. Here we will in particular consider nanoelectromechanical dynamics far from equilibrium and the effect of quantum coherence in both the electronic and mechanical degrees of freedom in the context of both normal and superconducting nanostructures.
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