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A Visual History of HIV/AIDS : Exploring the Face of AIDS Film Archive
- 2019
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- The Face of AIDS film archive at Karolinska Institutet, Sweden, consists of more than 700 hours of unedited and edited footage, shot over a period of more than thirty years and all over the world by filmmaker and journalist Staffan Hildebrand. The material documents the HIV/AIDS pandemic and includes scenes from conferences and rallies, and interviews with activists, physicians, people with the infection, and researchers. It represents a global historical development from the early years of the AIDS crisis to a situation in which it is possible to live a normal life with the HIV virus. This volume brings together a range of academic perspectives – from media and film studies, medical history, gender studies, history, and cultural studies – to bear on the archive, shedding light on memories, discourses, trauma, and activism.Using a medical humanities framework, the editors explore the influence of historical representations of HIV/AIDS and stigma in a world where antiretroviral treatment has fundamentally altered the conditions under which many people diagnosed with HIV live. Organized into four sections, this book begins by introducing the archive and its role, setting it in a global context. The first part looks at methodological, legal and ethical issues around archiving memories of the present which are then used to construct histories of the past; something that can be particularly controversial when dealing with a socially stigmatized epidemic such as HIV/AIDS. The second section is devoted to analyses of particular films from the archive, looking at the portrayal of people living with HIV/AIDS, the narrative of HIV as a chronic illness and the contemporary context of particular films. The third section looks at how stigma and trauma are negotiated in the material in the Face of AIDS film archive, discussing ideas about suffering and culpability. The final section contributes perspectives on and by the filmmaker as activist and auteur.This interdisciplinary collection is placed at the intersection of medical humanities, sexuality studies and film and media studies, continuing a tradition of studies on the cultural and social understandings of HIV/AIDS.
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| 3. |
- Adman, Per, 1970-, et al.
(författare)
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Political integration in practice : explaining a time-dependent increase in political knowledge among immigrants in Sweden
- 2018
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Ingår i: Social Inclusion. - : Cogitatio. - 2183-2803. ; 6:3, s. 248-259
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Tidskriftsartikel (refereegranskat)abstract
- Scholarly findings suggest that immigrants in Western countries, in general, participate less in politics and show lower levels of political efficacy than native-born citizens. Research is scarce, however, when it comes to immigrants’ knowledge about politics and public affairs in their new home country, and what happens with this knowledge over the years. This article focuses on immigrants in Sweden, a country known for ambitious multicultural policies, but where immigrants also face disadvantages in areas such as labor and housing markets. Utilizing particularly suitable survey data we find that immigrants, in general, know less about Swedish politics than natives, but also that this difference disappears with time. Exploring the influence of time of residence on political knowledge, the article shows that the positive effect of time in Sweden among immigrants remains after controlling for an extensive set of background factors. Moreover, the article examines this political learning effect through the lens of an Ability–Motivation–Opportunity (AMO) model. The findings suggest that the development of an actual ability to learn about Swedish politics—via education in Sweden, and by improved Swedish language skills—is an especially important explanation for the increase in political knowledge.
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| 4. |
- Adman, Per, 1970-, et al.
(författare)
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Political Trust as Modest Expectations : Exploring Immigrants' Falling Confidence in Swedish Political Institutions
- 2015
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Ingår i: Nordic Journal of Migration Research. - : Helsinki University Press. - 1799-649X. ; 5:3, s. 107-116
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Tidskriftsartikel (refereegranskat)abstract
- Political trust among immigrants in Western Europe seems to be surprisingly high, especially among immigrants from non-democratic countries with institutions plagued by corruption. Over time, however, trust tends to diminish among these individuals. In this paper we argue that this may neither be explained by acculturation nor by experiences of discrimination. Analysing Swedish survey data we instead conclude, although tentatively, that falling expectations regarding the performance of host country institutions is a fruitful explanation. Such expectations presumably become more modest the longer one has been living in Sweden, causing a time-related drop in the overall confidence in Swedish political institutions.
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| 5. |
- Adman, Per, 1970-, et al.
(författare)
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Time for Tolerance : Exploring the Influence of Learning Institutions on the Recognition of Political Rights Among Immigrants
- 2018
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Ingår i: Comparative Migration Studies. - : Springer. - 2214-8590 .- 2214-594X. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- This paper empirically evaluates the idea that individual level political tolerance is influenced by the overall tolerance in a given society. The expectation is that more tolerant attitudes would be developed as a consequence of exposure to a social environment in which people in general are more inclined to accept freedom of speech, also when a specific message challenges one’s own values and beliefs. A theoretical learning model is formulated, according to which more broad-minded and permissive attitudes, from a democratic point of view, are adopted as a result of (1) an adjustment stimulated by mere observation of an overall high-level of political tolerance in society (‘passive learning’), and (2) an adjustment due to cognition and interaction within important spheres in society (‘active learning’). Using survey data, we explore empirically how length of residence among immigrants in the high-tolerance country of Sweden is related to measures of political tolerance. Further, we examine to what extent a time-related effect is mediated through participation in a set of ‘learning institutions’—focusing on activities related to education, working-life, civil society and political involvement. In concert with expectations, the empirical findings suggest that a positive effect of time in Sweden on political tolerance may be explained by a gradual adoption of the principle that political rights should be recognized. Importantly, however, such an adoption seems to require participation in activities of learning institutions, as we find that passive learning in itself is not sufficient.
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| 8. |
- Aeinehband, Shahin, et al.
(författare)
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Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis
- 2015
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent large rat genomewide expression profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholinesterase (BuChE), an enzyme hydrolyzing acetylcholine (ACh), a classical neurotransmitter with immunoregulatory effects. We here determined levels of neurofilament-light (NFL), a marker for ongoing nerve injury, C3 and activity of the two main ACh hydrolyzing enzymes, acetylcholinesterase (AChE) and BuChE, in cerebrospinal fluid (CSF) from patients with MS (n = 48) and non-inflammatory controls (n = 18). C3 levels were elevated in MS patients compared to controls and correlated both to disability and NFL. C3 levels were not induced by relapses, but were increased in patients with >= 9 cerebral lesions on magnetic resonance imaging and in patients with progressive disease. BuChE activity did not differ at the group level, but was correlated to both C3 and NFL levels in individual samples. In conclusion, we show that CSF C3 correlates both to a marker for ongoing nerve injury and degree of disease disability. Moreover, our results also suggest a potential link between intrathecal cholinergic activity and complement activation. These results motivate further efforts directed at elucidating the regulation and effector functions of the complement system in MS, and its relation to cholinergic tone.
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| 9. |
- Ahlstrand, Emma, et al.
(författare)
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Interaction Energies in Complexes of Zn and Amino Acids : A Comparison of Ab Initio and Force Field Based Calculations
- 2017
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Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 121:13, s. 2643-2654
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Tidskriftsartikel (refereegranskat)abstract
- Zinc plays important roles in structural stabilization of proteins, eniyine catalysis, and signal transduction. Many Zn binding sites are located at the interface between the protein and the cellular fluid. In aqueous solutions, Zn ions adopt an octahedral coordination, while in proteins zinc can have different coordinations, with a tetrahedral conformation found most frequently. The dynainics of Zn binding to proteins and the formation of complexes that involve Zn are dictated by interactions between Zn and its binding partners. We calculated the interaction energies between Zn and its ligands in complexes that mimic protein binding sites and in Zn complexes of water and one or two amino acid moieties, using quantum mechanics (QM) and molecular mechanics (MM). It was found that MM calculations that neglect or only approximate polarizability did not reproduce even the relative order of the QM interaction energies in these complexes. Interaction energies calculated with the CHARMM-Diode polarizable force field agreed better with the ab initio results,:although the deviations between QM and MM were still rather large (40-96 kcallmol). In order to gain further insight into Zn ligand interactions, the free energies of interaction were estimated by QM calculations with continuum solvent representation, and we performed energy decomposition analysis calculations to examine the characteristics of the different complexes. The ligand-types were found to have high impact on the relative strength of polarization and electrostatic interactions. Interestingly, ligand ligand interactions did not play a significant role in the binding of Zn. Finally) analysis of ligand exchange energies suggests that carboxylates could be exchanged with water molecules, which explains the flexibility in Zn:binding dynamics. An exchange between earboxylate (Asp/Glii) and imidazole (His) is less likely.
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| 10. |
- Ahrens, Maryon, et al.
(författare)
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Multi-messenger Observations of a Binary Neutron Star Merger
- 2017
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 848:2
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Tidskriftsartikel (refereegranskat)abstract
- On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of similar to 1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg(2) at a luminosity distance of 40(-8)(+8) Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 M-circle dot. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at similar to 40 Mpc) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over similar to 10 days. Following early non-detections, X-ray and radio emission were discovered at the transient's position similar to 9 and similar to 16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta.
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