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  • A Visual History of HIV/AIDS : Exploring the Face of AIDS Film Archive
  • 2019
  • Samlingsverk (redaktörskap) (refereegranskat)abstract
    • The Face of AIDS film archive at Karolinska Institutet, Sweden, consists of more than 700 hours of unedited and edited footage, shot over a period of more than thirty years and all over the world by filmmaker and journalist Staffan Hildebrand. The material documents the HIV/AIDS pandemic and includes scenes from conferences and rallies, and interviews with activists, physicians, people with the infection, and researchers. It represents a global historical development from the early years of the AIDS crisis to a situation in which it is possible to live a normal life with the HIV virus. This volume brings together a range of academic perspectives – from media and film studies, medical history, gender studies, history, and cultural studies – to bear on the archive, shedding light on memories, discourses, trauma, and activism.Using a medical humanities framework, the editors explore the influence of historical representations of HIV/AIDS and stigma in a world where antiretroviral treatment has fundamentally altered the conditions under which many people diagnosed with HIV live. Organized into four sections, this book begins by introducing the archive and its role, setting it in a global context. The first part looks at methodological, legal and ethical issues around archiving memories of the present which are then used to construct histories of the past; something that can be particularly controversial when dealing with a socially stigmatized epidemic such as HIV/AIDS. The second section is devoted to analyses of particular films from the archive, looking at the portrayal of people living with HIV/AIDS, the narrative of HIV as a chronic illness and the contemporary context of particular films. The third section looks at how stigma and trauma are negotiated in the material in the Face of AIDS film archive, discussing ideas about suffering and culpability. The final section contributes perspectives on and by the filmmaker as activist and auteur.This interdisciplinary collection is placed at the intersection of medical humanities, sexuality studies and film and media studies, continuing a tradition of studies on the cultural and social understandings of HIV/AIDS.
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  • Aabel, Peder, et al. (författare)
  • Transcription and microRNA Profiling of Cultured Human Tympanic Membrane Epidermal Keratinocytes
  • 2018
  • Ingår i: Journal of the Association for Research in Otolaryngology. - : SPRINGER. - 1525-3961 .- 1438-7573. ; 19:3, s. 243-260
  • Tidskriftsartikel (refereegranskat)abstract
    • The human tympanic membrane (TM) has a thin outer epidermal layer which plays an important role in TM homeostasis and ear health. The specialised cells of the TM epidermis have a different physiology compared to normal skin epidermal keratinocytes, displaying a dynamic and constitutive migration that maintains a clear TM surface and assists in regeneration. Here, we characterise and compare molecular phenotypes in keratinocyte cultures from TM and normal skin. TM keratinocytes were isolated by enzymatic digestion and cultured in vitro. We compared global mRNA and microRNA expression of the cultured cells with that of human epidermal keratinocyte cultures. Genes with either relatively higher or lower expression were analysed further using the biostatistical tools g:Profiler and Ingenuity Pathway Analysis. Approximately 500 genes were found differentially expressed. Gene ontology enrichment and Ingenuity analyses identified cellular migration and closely related biological processes to be the most significant functions of the genes highly expressed in the TM keratinocytes. The genes of low expression showed a marked difference in homeobox (HOX) genes of clusters A and C, giving the TM keratinocytes a strikingly low HOX gene expression profile. An in vitro scratch wound assay showed a more individualised cell movement in cells from the tympanic membrane than normal epidermal keratinocytes. We identified 10 microRNAs with differential expression, several of which can also be linked to regulation of cell migration and expression of HOX genes. Our data provides clues to understanding the specific physiological properties of TM keratinocytes, including candidate genes for constitutive migration, and may thus help focus further research.
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  • Aaboud, M., et al. (författare)
  • Direct top-quark decay width measurement in the t(t)over-bar lepton plus jets channel at root s=8 TeV with the ATLAS experiment
  • 2018
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents a direct measurement of the decay width of the top quark using t (t) over bar events in the lepton+jets final state. The data sample was collected by the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of 8 TeV and corresponds to an integrated luminosity of 20.2 fb(-1). The decay width of the top quark is measured using a template fit to distributions of kinematic observables associated with the hadronically and semileptonically decaying top quarks. The result, Gamma(t) = 1.76 +/- 0.33 (stat.) (+0.79)(-0.68) (syst.) GeV for a top-quark mass of 172.5 GeV, is consistent with the prediction of the Standard Model.
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  • Aaboud, M, et al. (författare)
  • Measurement of fiducial and differential W+W- production cross-sections at √s=13 TeV with the ATLAS detector
  • 2019
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:10
  • Tidskriftsartikel (refereegranskat)abstract
    • A measurement of fiducial and differential cross-sections for W+W- production in proton–proton collisions at s=13 TeV with the ATLAS experiment at the Large Hadron Collider using data corresponding to an integrated luminosity of 36.1 fb - 1 is presented. Events with one electron and one muon are selected, corresponding to the decay of the diboson system as WW→ e±νμ∓ν. To suppress top-quark background, events containing jets with a transverse momentum exceeding 35 GeV are not included in the measurement phase space. The fiducial cross-section, six differential distributions and the cross-section as a function of the jet-veto transverse momentum threshold are measured and compared with several theoretical predictions. Constraints on anomalous electroweak gauge boson self-interactions are also presented in the framework of a dimension-six effective field theory. © 2019, CERN for the benefit of the ATLAS collaboration.
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  • Aaboud, M, et al. (författare)
  • Measurement of jet pT correlations in Pb + Pb and pp collisions at sNN=2.76 TeVwith the ATLAS detector
  • 2017
  • Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 774, s. 379-402
  • Tidskriftsartikel (refereegranskat)abstract
    • Measurements of dijet pT correlations in Pb+Pb and pp collisions at a nucleon–nucleon centre-of-mass energy of sNN=2.76 TeV are presented. The measurements are performed with the ATLAS detector at the Large Hadron Collider using Pb+Pb and pp data samples corresponding to integrated luminosities of 0.14 nb−1 and 4.0 pb−1, respectively. Jets are reconstructed using the anti-kt algorithm with radius parameter values R=0.3 and R=0.4. A background subtraction procedure is applied to correct the jets for the large underlying event present in Pb+Pb collisions. The leading and sub-leading jet transverse momenta are denoted pT1 and pT2. An unfolding procedure is applied to the two-dimensional (pT1,pT2) distributions to account for experimental effects in the measurement of both jets. Distributions of (1/N)dN/dxJ, where xJ=pT2/pT1, are presented as a function of pT1 and collision centrality. The distributions are found to be similar in peripheral Pb+Pb collisions and pp collisions, but highly modified in central Pb+Pb collisions. Similar features are present in both the R=0.3 and R=0.4 results, indicating that the effects of the underlying event are properly accounted for in the measurement. The results are qualitatively consistent with expectations from partonic energy loss models. © 2017 The Author
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