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- Astermark, Jan, et al.
(författare)
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Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study.
- 2009
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Ingår i: Gematologiâ i Transfuziologiâ. - 0234-5730. ; 54:5, s. 35-35
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Tidskriftsartikel (refereegranskat)abstract
- Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. J. Astermark(1), Sh. M. Donfield(2), D. M. DiMichele(3), A. Gringeri(4), S. A. Gilbert(2), J. Waters(2), E. Berntorp(1), for the FENOC Study Group. Department for Hematology and Coagulation Disorders, Malmo, University Hospital, Malmo, Sweden(1); Department of Biostatistics, Rho, Chapel Hill, NC2; Department of Pediatrics, Weill Medical College, Cornell University, New York, NY3; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy(4). The development of inhibitory antibodies to factor VIII is a serious complication of hemophilia. FEIBA (factor VIII inhibitorbypassing activity), an activated prothrombin complex concentrate (aPCC), and NovoSeven, recombinant factor Vila (rFVIIa), are used as hemostatic bypassing agents in treating patients with inhibitors. The FENOC study was designed to test equivalence of the products in the treatment of ankle, knee, and elbow joint bleeding. A prospective, open-label, randomized, crossover, equivalency design was used. The parameters of interest were the percentage of patients who reported efficacy in response to FEIBA and the percentage that reported efficacy in response to NovoSeven. A difference in these percentages of no more than 15% was determined to be a clinically acceptable magnitude for equivalence of the 2 products. The primary outcome was evaluation 6 hours after treatment. Data for 96 bleeding episodes contributed by 48 participants were analyzed. The criterion for declaring the 2 products equivalent at 6 hours was not met; however, the confidence interval of the difference in percentages of efficacy reported for each product only slightly exceeded the 15% boundary (11.4-15.7%); p = 0.059. FEIBA and NovoSeven appear to exhibit a similar effect on joint bleeds, although the efficacy between products is rated differently by a substantial proportion of patients. This trial was registered at www.clinicaltrials.gov.
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| 3. |
- Burova, L. A., et al.
(författare)
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Nephritogenic activity of IgA-binding streptococcus pyogenes : An experimental model of IgA glomerulonephritis
- 2016
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Ingår i: Medical Immunology (Russia). - 1563-0625. ; 18:3, s. 221-230
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Tidskriftsartikel (refereegranskat)abstract
- The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity mediated by the IgAFc microbial receptors. The renal tissue damage was developed in most animals treated with emm60 S. pyogenes characterized by marked IgAFcR expression and higher IgA-binding ability. By means of morphometric analysis. Significant morphological and immunochemical glomerular changes were revealed in 6/10 rabbits, as follows: (i) massive IgA deposition in the mesangial glomerular cells, atrophy of the capillary net, and tissue oedema; (ii) marked C3-complement deposition in proximal and distal tubules; (iii) a significant infiltration of cortical and medullar areas by lymphocytes associated with weak TNFα production. Noteworthy, we did not observe local IgG deposition in any cases, thus allowing to exclude any role of anti-IgG, or other IgG's in evolution of the pathology. Alternatively, the IgA-deposits may occur due to microbial IgA FcR-IgAcontaining cmplexes, as earlier shown by the Swedish scientists. The above tissue changes were completely absent in kidneys of control animals. Taken together, these data suggest that we have developed an experimental model similar to IgA-nephropathy in humans. The results also extend our knowledge on pathogenic effects of the IgA Fc-binding proteins of Streptococcus pyogenes.
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| 8. |
- Dunér, David
(författare)
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Человеческий разум в пространстве и во времени : пролегомены к когнитивной истории
- 2021
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Ingår i: Istoriya. - 2079-8784. ; 12:8
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Tidskriftsartikel (refereegranskat)abstract
- The last decades have seen a noticeable increase in cognitive science studies that have changed the understanding of human thinking. Its relevance for historical research cannot be overlooked any more. Cognitive history could be explained as the study of how humans in history used their cognitive abilities in order to understand the world around them and to orient themselves in it, but also how the world outside their bodies affected their way of thinking. In focus for this introductory chapter is the relationship between history and cognition, the human mind’s interaction with the environment in time and space. The chapter discusses certain cognitive abilities in interaction with the environment, which can be studied in historical sources, namely: embodied mind, situated cognition, perception, distributed cognition, conceptual metaphors, categorization, intersubjectivity, and communication. These cognitive theories can give deeper understanding of how — and not only what — humans thought, and about the interaction between the human mind and the surrounding world. The most ambitious aim of such a cognitive history could be to inform the research on the cognitive evolution of the human mind.
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| 10. |
- Gladkochub, D. P., et al.
(författare)
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РАСШИРЕНИЕ АРЕАЛА ТИМПТОНСКОЙ КРУПНОЙ МАГМАТИЧЕСКОЙ ПРОВИНЦИИ (~1.75 МЛРД ЛЕТ) СИБИРСКОГО КРАТОНА
- 2019
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Ingår i: Geodynamics and Tectonophysics. - 2078-502X. ; 10:4, s. 829-839
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Tidskriftsartikel (refereegranskat)abstract
- We present new geochronological data on dolerites from the Chaya dyke swarm of the Baikal inlier of the Siberian craton. The U-Pb dating of baddeleyite from one dyke located at the SW end of the Chaya dyke swarm yielded an age of 1752±6 Ma, similar to the previously obtained age of a dyke in the NE end of this swarm. These ages establish an age of 1752 Ma for a unified Chaya dyke swarm that extends for more than 200 km in the Baikal inlier of the Siberian craton. These new data confirm that the entire Chaya dyke swarm (as well as the Timpton-Algamay and Eastern Anabar swarms) is a part of an overall radiating dyke swarm belonging to the Late Paleoproterozoic Timpton Large Igneous Province (LIP), the center of which is located in the middle section of the Vilyuy river flow. Thus, the LIP is enlarged to include the area further west in the Siberian craton.
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