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Sökning: Nicaragua > Göteborgs universitet

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  • Bucardo, F, et al. (författare)
  • Genetic susceptibility to symptomatic norovirus infection in Nicaragua.
  • 2009
  • Ingår i: Journal of medical virology. - 1096-9071. ; 81:4, s. 728
  • Tidskriftsartikel (refereegranskat)abstract
    • Host genetic resistance to Norovirus (NoV) has been observed in challenge and outbreak studies in populations from Europe, Asia, and USA. In this study, we have investigated if histo-blood group antigens can predict susceptibility to diarrhea caused by NoV in Nicaragua, Central America, and if this can be reflected in antibody-prevalence and titer to NoV among individuals with different histo-blood group antigen phenotypes. Investigation of 28 individuals infected with NoV and 131 population controls revealed 6% of non-secretors in the population and nil non-secretors among patients infected with NoV, suggesting that non-secretors may be protected against NoV disease in Nicaragua. Surprisingly, 25% of the population was Lewis negative (Le(a-b-)). NoV infections with genogroup I (GI) and GII occurred irrespective of Lewis genotype, but none of the Lewis a positive (Le(a + b-)) were infected. The globally dominating GII.4 virus infected individuals of all blood groups except AB (n = 5), while the GI viruses (n = 4) infected only blood type O individuals. Furthermore, O blood types were susceptible to infections with GI.4, GII.4, GII.7, GII.17, and GII.18-Nica viruses, suggesting that secretors with blood type O are susceptible (OR = 1.52) and non-secretors resistant. The overall antibody-prevalence to NoV GII.3 VLP was 62% with the highest prevalence among blood type B carriers (70%) followed by A (68%) and O (62%). All four investigated individuals carrying blood type AB were antibody-negative. Among secretors, 63% were antibody-positive compared to 33% among non-secretors (P = 0.151). This study extends previous knowledge about the histo-blood group antigens role in NoV disease in a population with different genetic background than North American and European.
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  • Wedel, Johan, 1962- (författare)
  • Sorcery and Violence in Eastern Nicaragua
  • 2010
  • Ingår i: 35th Caribbean Studies Association Conference, May 24-28, St. Peters, Barbados.
  • Konferensbidrag (övrigt vetenskapligt)
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  • Salas, Osvaldo, 1953- (författare)
  • La Economía de Nicaragua
  • 1989
  • Ingår i: Anales. Iberoamerikanska Institutet, GU. ; 1, s. 179-194
  • Tidskriftsartikel (övrigt vetenskapligt)
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