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Kidney function in sugarcane cutters in Nicaragua - A longitudinal study of workers at risk of Mesoamerican nephropathy
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Wesseling, C. (författare)
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Aragon, A. (författare)
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Gonzalez, M. (författare)
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Weiss, I. (författare)
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Glaser, J. (författare)
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Bobadilla, N. A. (författare)
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Roncal-Jimenez, C. (författare)
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Correa-Rotter, R. (författare)
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Johnson, R. J. (författare)
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- Barregård, Lars, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 147, s. 125-132
- Relaterad länk:
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https://researchonli...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Chronic kidney disease is common among sugarcane workers in Central America. The main risk factor seems to be repeated high-intensity work in hot environments. Several cross-sectional studies have been performed but few longitudinal studies. Objectives: The aim of the study was to examine whether kidney function changes over a few months of work during the harvest period. Methods: A group of male sugarcane cutters in Nicaragua (N=29, aged 17-38 years) was examined with renal biomarkers before and after shift on the first day at the start of harvest, on the sixth day during acclimatization, and then in mid-harvest 9 weeks later. A reference group (N=25, mainly office workers) was examined with the same biomarkers at start of harvest, and then at end of harvest 5 months later. Results: The pre-shift renal function decreased significantly during 9 weeks of work in the cane cutters. Mean serum creatinine increased (20%), mean estimated glomerular filtration rate decreased (9%, 10 mL/min), serum urea N (BUN) increased (41%), and mean urinary neutrophil gelatinase-associated lipocalin (NGAL) increased (four times). The cane cutters also developed cross-shift increases in these biomarkers, in particular serum creatinine and BUN, and in urinary uric acid. The longitudinal decrease in eGFR tended to be associated with the cross-shift increase in serum creatinine. Conclusions: There was a remarkable decrease of glomerular kidney function, after only 9 weeks of harvest. The cross-shift increase in serum creatinine may be caused by dehydration (pre-renal dysfunction), and when repeated on a daily basis this may cause permanently reduced GFR. (C) 2016 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Chronic kidney disease
- Heat stress
- Occupational
- eGFR
- BUN
- NGAL
- KIM-1
- Hsp72
- glomerular-filtration-rate
- central-america
- heat-stress
- disease
- injury
- dehydration
- communities
- salvador
- ckd
- Environmental Sciences & Ecology
- Public
- Environmental & Occupational
- Health
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Wesseling, C.
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Aragon, A.
-
Gonzalez, M.
-
Weiss, I.
-
Glaser, J.
-
Bobadilla, N. A.
-
visa fler...
-
Roncal-Jimenez, ...
-
Correa-Rotter, R ...
-
Johnson, R. J.
-
Barregård, Lars, ...
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visa färre...
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