Sökning: Nicaragua
> Göteborgs universitet
> Lundin Samuel B 1970 >
Identification of a...
Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua
-
- Thorell, Kaisa, 1983 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
-
- Hesseini, Seyed Vali, 1975 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Gonzales, Rvpp (författare)
- Salud Integral Hospital
-
visa fler...
-
- Chaotham, Chatchai (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg
-
- Graham, D. Y. (författare)
- Baylor College of Medicine
-
- Paszat, L. (författare)
- University of Toronto
-
- Rabeneck, L. (författare)
- University of Toronto
-
- Lundin, Samuel B, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg
-
- Nookaew, Intawat, 1977 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Sjöling, Åsa, 1968 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg
-
visa färre...
-
(creator_code:org_t)
- 2016-02-29
- 2016
- Engelska.
-
Ingår i: BMC Evolutionary Biology. - : Springer Science and Business Media LLC. - 1471-2148. ; 16
- Relaterad länk:
-
https://gup.ub.gu.se... (primary) (free)
-
visa fler...
-
https://bmcevolbiol....
-
http://publications.... (primary) (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Helicobacter pylori (H. pylori) is one of the most common bacterial infections in humans and this infection can lead to gastric ulcers and gastric cancer. H. pylori is one of the most genetically variable human pathogens and the ability of the bacterium to bind to the host epithelium as well as the presence of different virulence factors and genetic variants within these genes have been associated with disease severity. Nicaragua has particularly high gastric cancer incidence and we therefore studied Nicaraguan clinical H. pylori isolates for factors that could contribute to cancer risk. Methods: The complete genomes of fifty-two Nicaraguan H. pylori isolates were sequenced and assembled de novo, and phylogenetic and virulence factor analyses were performed. Results: The Nicaraguan isolates showed phylogenetic relationship with West African isolates in whole-genome sequence comparisons and with Western and urban South-and Central American isolates using MLSA (Multi-locus sequence analysis). A majority, 77 % of the isolates carried the cancer-associated virulence gene cagA and also the s1/i1/m1 vacuolating cytotoxin, vacA allele combination, which is linked to increased severity of disease. Specifically, we also found that Nicaraguan isolates have a blood group-binding adhesin (BabA) variant highly similar to previously reported BabA sequences from Latin America, including from isolates belonging to other phylogenetic groups. These BabA sequences were found to be under positive selection at several amino acid positions that differed from the global collection of isolates. Conclusion: The discovery of a Latin American BabA variant, independent of overall phylogenetic background, suggests hitherto unknown host or environmental factors within the Latin American population giving H. pylori isolates carrying this adhesin variant a selective advantage, which could affect pathogenesis and risk for sequelae through specific adherence properties.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Helicobacter
- Whole-genome sequencing
- Phylogeny
- Virulence factors
- BabA
- Virulence factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Thorell, Kaisa, ...
-
Hesseini, Seyed ...
-
Gonzales, Rvpp
-
Chaotham, Chatch ...
-
Graham, D. Y.
-
Paszat, L.
-
visa fler...
-
Rabeneck, L.
-
Lundin, Samuel B ...
-
Nookaew, Intawat ...
-
Sjöling, Åsa, 19 ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
BMC Evolutionary ...
- Av lärosätet
-
Göteborgs universitet
-
Chalmers tekniska högskola
-
Karolinska Institutet