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Sökning: WAKA:ref > Göteborgs universitet > (2000-2004) > (2000)

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  • Abrahamsson, Kajsa H., 1956, et al. (författare)
  • Psychosocial aspects of dental and general fears in dental phobic patients.
  • 2000
  • Ingår i: Acta odontologica Scandinavica. - : Informa UK Limited. - 0001-6357 .- 1502-3850. ; 58:1, s. 37-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Phobic reactions can often be a significant health problem for fearful dental patients. This is true in particular for individuals with long-time avoidance and elevated general psychological distress. The aim of this study was to investigate the expression of dental fear among 67 dental phobic individuals with a low versus high degree of general fear. Reported etiologic background factors, avoidance time, general psychological distress and psychosocial manifestations and consequences of dental phobia were studied. No significant difference in dental anxiety level between individuals with low versus high general fear was found, and both groups reported high frequencies of negative dental experiences. The low-fear group reported a longer (though not statistically significant) average avoidance time than the high-fear group. However, patients with a high level of general fear showed a significantly higher degree of psychological distress, and also reported stronger negative social consequences from their dental anxiety. These results indicate that the character of dental fear might be different between different groups of fearful patients, which makes the condition psychologically handicapping. Such aspects should be assessed in the diagnostic analysis of patients with severe dental anxiety. In particular, assessments of signs of general psychological distress are warranted.
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  • Agewall, S, et al. (författare)
  • Insulin sensitivity and hemostatic factors in clinically healthy 58-year-old men.
  • 2000
  • Ingår i: Thrombosis and haemostasis. - 0340-6245. ; 84:4, s. 571-5
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this cross-sectional study was to investigate the relationship between factors of the coagulation- and fibrinolysis systems and insulin sensitivity in 104 clinically healthy, 58-years-old men. Insulin sensitivity (hyperinsulinemic euglycemic clamp) adjusted for lean body mass, the metabolic syndrome according to a suggested definition, and different factors in the coagulation- and fibrinolysis system were determined. Subjects with the metabolic syndrome were characterised by increases in PAI-1 activity, tPA antigen, protein C and protein S and low concentrations of tPA activity. Insulin sensitivity was independently and reversibly associated with PAI-1 (p = 0.014) and directly with tPA activity (p = 0.001). Insulin sensitivity was also significantly negatively associated with protein S and protein C and several components in the metabolic syndrome, however not remaining significant in multivariate analyses. Protein C and protein S were significantly associated with PAI-1 activity, tPA activity (negatively), tPA antigen and antithrombin III. In conclusion, the data indicated that insulin resistance and several of the clustering components in the metabolic syndrome are accompanied by increased plasma concentrations of the anticoagulatory proteins C and S which may represent a mechanism which counteracts the concomitantly occurring hypofibrinolysis.
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6.
  • Ahlborg, Gunnar, 1948 (författare)
  • Occupational and environmental medicine in Sweden
  • 2000
  • Ingår i: International Archives of Occupational and Environmental Health. - 0340-0131. ; 73:1, s. 1-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Great changes have taken place in the fields of occupational and environmental medicine in Sweden during the past decade. Unemployment, work stress, and indoor climate problems have become increasingly common. Chemical exposures in industry and serious work accidents have continued to decrease. State subsidies to occupational health services have been withdrawn and the legislation concerning, for example, occupational diseases has been changed in order to decrease state expenditure. Research has focused on, for instance, ergonomic and psycho-social factors, electromagnetic fields and exposures causing allergy. There is a growing awareness of the need for more emphasis on prevention, which should act in favour of both hospital-based occupational and environmental medicine and the occupational health services sector.
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7.
  • Ahlman, Håkan, 1947, et al. (författare)
  • Interventional treatment of gastrointestinal neuroendocrine tumours.
  • 2000
  • Ingår i: Digestion. - 0012-2823. ; 62 Suppl 1, s. 59-68
  • Tidskriftsartikel (refereegranskat)abstract
    • Neuroendocrine (NE) tumours of the gastrointestinal tract (carcinoids and endocrine pancreatic tumours) are rare diseases. In the presence of liver metastases these patients may suffer from disabling symptoms due to hormone overproduction. Patients with localized disease can be resected for cure and also patients with liver metastases can undergo potentially curative tumour resection. However, long-term follow-up of the latter cases indicates frequent recurrence of tumour. Using close biochemical monitoring of tumour markers combined with newer techniques for tumour visualization, these recurrences can often be diagnosed at an early stage so that repeat surgical procedures can be performed. During the last years very active surgery has been recommended for NE tumours, many of which have a relatively slow growth. Even in patients not amenable to curative liver surgery, debulking can be considered if the main tumour burden can be safely excised. The primary aim of this type of treatment is palliation of hormonal symptoms. An important question is whether the aggressive treatment actually prolongs survival. No prospective studies have been performed. Such studies are hampered by the lack of strict surgical programs running over long periods and the relative rarity of NE tumours. Liver transplantation may be another treatment modality in selected cases.
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  • Akhtar, N, et al. (författare)
  • SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase.
  • 2000
  • Ingår i: FEBS letters. - 0014-5793. ; 483:2-3, s. 87-92
  • Tidskriftsartikel (refereegranskat)abstract
    • We here report the identification of the previously uncharacterized SGD1 gene, encoding a 102.8-kDa protein containing a leucine zipper region and a bipartite nuclear localization signal. Deletion of SGD1 results in loss of cell viability, while an increased dosage of SGD1 partially suppresses the osmosensitivity of pbs2 delta and hog1 delta mutants that are defective in the osmosignaling high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway. The rescued mutants display a partially re-established transcriptional control of the osmostress-induced expression of GPD1, a target gene of the HOG pathway encoding NAD(+)-dependent glycerol 3-phosphate dehydrogenase, and a partially recovered hyperosmolarity-induced production of glycerol. Consistent with Sgd1p affecting the transcriptional control of GPD1, a functional green fluorescent protein tagged Sgd1p is localized to the cell nucleus.
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