| 1. |
- Adeyinka, A, et al.
(författare)
-
Comparative cytogenetic and DNA flow cytometric analysis of 242 primary breast carcinomas
- 2003
-
Ingår i: Cancer Genetics and Cytogenetics. - Elsevier Science. - 0165-4608. ; 147:1, s. 62-67
-
Tidskriftsartikel (refereegranskat)abstract
- The cytogenetic and DNA flow cytometric findings in 242 breast carcinomas were compared. The combined use of both techniques improved the detection of abnormal cell populations from 65% by cytogenetic analysis alone and 59% by DNA flow cytometric analysis alone to 84%. Informative and comparable cytogenetic and flow cytometric data were obtained for 155 tumors. Among these 155 tumors, there was good concordance (64%) between the estimates of genomic changes by the two methods. Most discrepancies were among the DNA-diploid cases, where cytogenetic analysis detected small genomic changes. There were, however, also some exceptions in which large genomic changes detected by one method were missed by the other. Of the specific breast cancer-associated cytogenetic aberrations subjected to separate correlation analysis, polysomy for chromosome 20 was significantly associated with a high S-phase fraction, whereas loss of the long arm of chromosome 16 and/or the presence of a der(I; 16) were significantly associated with a low S-phase fraction. Our data show that cytogenetic and DNA flow cytometric analyses of breast carcinomas give largely comparable results, and that combining data from both methods significantly improves the information obtained by either technique used alone on the genetic abnormalities in these tumors. (C) 2003 Elsevier Inc. All rights reserved.
|
|
| 2. |
- Adiseno, et al.
(författare)
-
A wide-band RF front-end for multiband multistandard high-linearity low-IF wireless receivers
- 2002
-
Ingår i: IEEE Journal of Solid-State Circuits. - 0018-9200. ; 37:9, s. 1162-1168
-
Tidskriftsartikel (refereegranskat)abstract
- A wide-band radio-frequency (RF) front-end is designed with a balanced combined low-noise amplifier and a switching mixer (a low-noise converter) in RF Si-bipolar process with an f(T) of 25 GHz. The circuit achieves 20-dB conversion gain, higher than -4.5-dBm RF-to-IF IIP3 (+15.5-dBm OIP3) and less than 3.8-dB double-side-band noise figure in 900-MHz (e.g., GSM) and 1.9-GHz (e.g., WCDMA) frequency bands. The -1-dB compression point is -20 dBm at 13-mA dc current consumption from a single 5-V supply. The local-oscillator leakage to the input is less than -56 dBm in the 900-MHz band and less than -63 dBm in the 1.9-GHz band. The -3-dB bandwidth of the amplifier is larger than 3 GHz and a wide-band matching at the input with - 10 to -41-dB S-11 is achieved in the frequency bands of interest by applying a dual-loop wide-band active feedback. The die area is 0.69 x 0.9 mm(2). The circuit is suitable for area-efficient multiband multistandard low-IF receivers.
|
|
| 3. |
- Adiseno, et al.
(författare)
-
Multiband high-linearity front-end receivers for wireless applications
- 2002
-
Ingår i: Analog Integrated Circuits and Signal Processing. - 0925-1030. ; 30:1, s. 59-67
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, a modified front-end receiver configuration, which consists of an LNA and mixer suitable for zero-IF or low-IF receivers, is presented. The idea is to achieve a better linearity for receivers by combining circuit and system level solutions. Three circuit topologies, two in bipolar and one in CMOS technology, are presented in this paper with their simulation results. One of the bipolar topologies has been implemented and measurement results are presented. An IIP3 of up to +0.6 dBm of a combined bipolar LNA and mixer is achieved, depending on frequency of interest and with an acceptable noise figure performance at a current consumption of less than 13 mA from 5 V supply voltage in one circuit and 3 V supply voltage in the other one. An IIP3 up to +5 dBm is achieved for the CMOS topology at a lower overall gain and acceptable noise figure (14.4 mA and 3 V). All circuits presented in this paper are wideband circuits, suitable for area-efficient multiband receivers.
|
|
| 4. |
- Ahrens, Wolfgang, et al.
(författare)
-
Occupational exposure to endocrine-disrupting compounds and biliary tract cancer among men
- 2007
-
Ingår i: Scandinavian journal of work, environment & health. - Institute of Occupational Health. - 0355-3140. ; 33:5, s. 387-396
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: This study investigated the association between cancer of the extrahepatic biliary tract and exposure to endocrine-disrupting compounds. METHODS: Altogether 183 men with histologically confirmed carcinoma of the extrahepatic biliary tract and 1938 matched controls were interviewed between 1995 and 1997 in the frame of an international multicenter case-control study in six European countries (Denmark, France, Germany, Italy, Spain, and Sweden). Self-reported job descriptions were converted to semiquantitative variables (intensity, probability, and duration of exposure) for 14 endocrine-disrupting compounds. The cases were compared with 1421 population controls and 517 colon adenocarcinoma patients. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained with unconditional logistic regression and adjusted for age, country, and gallstones. RESULTS: Occupational exposure to endocrine-disrupting compounds resulted in an OR of 1.4 (95% CI 1.0-2.1) with no dose-effect relationship for cumulative exposure (low: OR 1.3, 95% CI 0.6-3.0; medium: OR 1.5, 95% CI 0.8-2.7; high: OR 1.4, 95% CI 0.9-2.4) (only index participants). The elevated risk was restricted to extrahepatic bile ducts and ampulla Vateri (OR 1.7, 95% CI 1.0-2.6). The adjusted OR for cancer of the extrahepatic biliary tract after exposure to polychlorinated biphenyls was 2.8 (95% CI 1.3-5.9, only index participants). CONCLUSIONS: The data show some associations between exposure to endocrine-disrupting compounds in the workplace and the risk for cancer of the extrahepatic biliary tract among men, particularly for the extrahepatic bile duct and ampulla of Vater. Polychlorinated biphenyls could possibly be a strong risk factor.
|
|
| 5. |
- Ahrens, Wolfgang, et al.
(författare)
-
Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study
- 2007
-
Ingår i: European journal of gastroenterology & hepatology. - Lippincott Williams & Wilkins, Inc.. - 0954-691X. ; 19:8, s. 623-630
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index height (m) divided by squared weight (kg2) >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable.
|
|
| 6. |
- Andrijevic, Goran, et al.
(författare)
-
A fully integrated low-IF DVB-T receiver architecture
- 2004
-
Ingår i: 2004 INTERNATIONAL SYMPOSIUM ON SYSTEM-ON-CHIP, PROCEEDINGS. - 0-7803-8558-6 ; s. 189-192
-
Konferensbidrag (refereegranskat)abstract
- We propose a fully integrated DVB-T receiver architecture for low cost CMOS implementation. The receiver uses a dual-IF architecture to cover the receive bands from 170 MHz to 862 MHz and a Low-IF of 4.57 MHz. Key performance values meet the DVB-T requirements with competitive performance (Sensitivity 72.5 dBm, Noise Figure 66 dB, Adjacent Channel Protection Ratio-ACPR=43dB, available SNR=28 dB) and suggest that low cost receivers are realistic in volume for the coming digital broadcasting systems.
|
|
| 7. |
- Andrijevic, Goran, et al.
(författare)
-
Multistandard receiver for home networking and digital media
- 2004
-
Ingår i: 22ND NORCHIP CONFERENCE, PROCEEDINGS. - NEW YORK : IEEE. - 0-7803-8510-1 ; s. 131-134
-
Konferensbidrag (refereegranskat)abstract
- We propose a fully integrated multistandard receiver architecture that fulfills coming media and networking needs of homes. The receiver uses a dual-IF architecture to cover receive bands from 170 MHz to 920 MHz and the Industrial, Scientific and Medical (ISM) band at 2.4GHz. Key performance values meet the DVB-T, Zigbee, Bluetooth and 802.11b requirements (Sensitivity -72.5dBm. available SNR=28dB. Noise Figure 6.7dB. Adjacent Channel Protection Ratio-ACPR=-44dB, IIP3 = -11 dBm).
|
|
| 8. |
- Antoniou, A C, et al.
(författare)
-
Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
- 2005
-
Ingår i: Journal of Medical Genetics. - BMJ Publishing Group. - 0022-2593. ; 42:7, s. 602-603
-
Tidskriftsartikel (refereegranskat)abstract
- A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an attempt to confirm this, the breast and ovarian cancer risks associated with the three Ashkenazi founder mutations were estimated using families included in a previous meta-analysis of populatrion based studies. The estimated breast cancer risks for each of the founder BRCA1 and BRCA2 mutations were similar to the corresponding estimates based on all BRCA1 or BRCA2 mutations in the meta-analysis. These estimates appear to be consistent with the observed prevalence of the mutations in the Ashkenazi Jewish population.
|
|
| 9. |
- Antoniou, Antonis C., et al.
(författare)
-
Reproductive and Hormonal Factors, and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers: Results from the International BRCA1/2 Carrier Cohort Study
- 2009
-
Ingår i: Cancer Epidemiology Biomarkers & Prevention. - Amer Assoc Cancer Research. - 1055-9965. ; 18:2, s. 601-610
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Several reproductive and hormonal factors are known to be associated with ovarian cancer risk in the general population, including parity and oral contraceptive (00 use. However, their effect on ovarian cancer risk for BRCA1 and BRCA2 mutation carriers has only been investigated in a small number of studies. Methods: We used data on 2,281. BRCA1. carriers and 1,038 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study to evaluate the effect of reproductive and hormonal factors on ovarian cancer risk for mutation carriers. Data were analyzed within a weighted Cox proportional hazards framework. Results: There were no significant differences in the risk of ovarian cancer between parous and nulliparous carriers. For parous BRCA1 mutation carriers, the risk of ovarian cancer was reduced with each additional full-term pregnancy (P trend = 0.002). BRCA1 carriers who had ever used OC were at a significantly reduced risk of developing ovarian cancer (hazard ratio, 0.52; 95% confidence intervals, 0.37-0.73; P = 0.0002) and increasing duration of OC use was associated with a reduced ovarian cancer risk (P trend = 0.0004). The protective effect of OC use for BRCA1 mutation carriers seemed to be greater among more recent users. Tubal ligation was associated with a reduced risk of ovarian cancer for BRCA1 carriers (hazard ratio, 0.42; 95% confidence intervals, 0.22-0.80; P = 0.008). The number of ovarian cancer cases in BRCA2 mutation carriers was too small to draw definitive conclusions. Conclusions: The results provide further confirmation that OC use, number of full-term pregnancies, and tubal ligation are associated with ovarian cancer risk in BRCA1 carriers to a similar relative extent as in the general population. (Cancer Epidemiol Biomarkers Prev 2009;18(2):601-10)
|
|
| 10. |
- Antoniou, A. C., et al.
(författare)
-
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
- 2008
-
Ingår i: British Journal of Cancer. - Nature Publishing Group. - 0007-0920. ; 98:8, s. 1457-1466
-
Tidskriftsartikel (refereegranskat)abstract
- Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families ( 301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920 - 1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in userfriendly Web-based program(http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home. html).
|
|
