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- Malmgren, Linnea, et al.
(författare)
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The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation.
- 2023
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Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 293:3, s. 293-308
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous GFR-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterised by a selective reduction in the glomerular filtration of 5-30 kDa molecules, such as cystatin C, compared to the filtration of small molecules < 1kDa dominating the glomerular filtrate e.g., water, urea, creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterised by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.
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| 2. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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Avkollegialiseringen av svenska lärosäten : En analys av statliga universitet och högskolor
- 2022
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Ingår i: Statsvetenskaplig Tidskrift. - Lund : Fahlbeckska stiftelsen. - 0039-0747. ; 124:1, s. 157-209
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Tidskriftsartikel (refereegranskat)abstract
- The Decollegialization of Higher Education Institutions – an Examination of Public Sector Higher Education Institutions in SwedenThis article surveys current management ideals of higher education institutions (HEIs), and our analytical focus is on the balance between line management and fac-ulty self-governance. We present an empirical study of evolving governance struc-tures including all 31 public sector HEIs in Sweden. The point of departure is the Autonomy Reform of 2011, which resulted in a deregulation of the Higher Education Act and a loss of constitutional support for collegial bodies. To assess the conse-quences of the reform, we have examined collegial bodies and academic leadership posts before and after the reform. Our findings show escalating line management in the appointment of academic leaders, a diluted role for collegial expertise, and a loss of decision-making authority for collegial bodies. Hence, the decollegialization of HEIs in Sweden. Our study contributes to the existing literature with an unusually comprehensive analysis of the consequences of new managerial ideals at the local institutional level.
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| 3. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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Svenska lärosäten : organisering, finansiering, positionering
- 2022
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Ingår i: Statsvetenskaplig Tidskrift. - Lund : Fahlbeckska stiftelsen. - 0039-0747. ; 124:1, s. 5-18
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Tidskriftsartikel (refereegranskat)abstract
- Våren 2021 tog riksdagen ställning till den elfte forskningspolitiska propositionen i ordningen, Forskning, frihet, framtid – kunskap och innovation för Sverige (prop. 2020/21:60). Bara genom att studera forskningspropositionernas rubriker kan man enkelt avläsa vilka primära mål sittande regering har med sin forskningspolitik. Förra gången det begav sig stod samverkan högst på agendan. På propositionens 167 sidor nämndes ”samverkan” hela 224 gånger, medan en konkurrent som ”frihet” i stort lyste med sin frånvaro och enbart nämndes sex gånger (prop. 2016/17:50). I den nu aktuella forskningspropositionen har emellertid ”frihet” getts en mer framträdande roll än någonsin tidigare – vilket även framgår av rubriken – och omnämns hela 141 gånger (”samverkan” är dock mer än dubbelt så vanligt) (prop. 2020/21:60). Skälet till att frihetsfrågan fått en så framträdande roll denna gång är förstås de förslag om att föra in akademisk frihet i högskolelagen som Styr- och resursutredningen presenterat i sitt betänkande (”Struten”, se SOU 2019:6). Men hur ska vi förstå denna politiska strävan efter att stärka den akademiska friheten? I detta specialnummer tar vi ett bredare grepp om hur högskolepolitiken utvecklats över tid, och frågar oss vad som utmärker denna frihet. Vem är det som ska ges frihet? Hur ser balansen mellan formell och reell frihet ut? Vad utmärker dem som skänks frihet – oftast lärosätena – och hur skiljer de sig åt?
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| 4. |
- Ahlbäck Öberg, Shirin, Professor, 1964-, et al.
(författare)
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The Decollegialization of Higher Education Institutions in Sweden
- 2023
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Ingår i: Nordic Journal of Studies in Educational Policy. - : Routledge. - 2002-0317. ; 9:2, s. 126-143
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Tidskriftsartikel (refereegranskat)abstract
- This article surveys current management ideals of higher education institutions, and our analytical focus is on the balance between line management and faculty self-governance. It presents an empirical study of evolving governance structures including all 31 public sector higher education institutions in Sweden. The point of departure is the Autonomy Reform of 2011, which resulted in a deregulation of the Higher Education Act, and a loss of constitutional support for collegial bodies. To assess the consequences of the reform, we have examined collegial bodies and academic leadership posts before the reform (2010) and after (2020). Our findings show escalating line management in the appointment of academic leaders, a diluted role for collegial expertise, and a loss of decision-making authority for collegial bodies. What we observe is the decollegialization of higher education institutions. Our study contributes to the existing literature with an unusually comprehensive and fine-grained analysis of the consequences of new managerial ideals at the local institutional level.
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| 5. |
- Anderson, Helén, et al.
(författare)
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Are Mergers or Acquisitions expected to affect customer and supplier relationships? : An Analysis of Decisions Taken by a Competition Authority
- 2003
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Konferensbidrag (refereegranskat)abstract
- Studies concerning corporate mergers and acquisitions are mainly focused on the merging companies. Recently though, there has been an increased interest concerning connected companies, e.g. those firms having customer, supplier or other business relationships with participants in a merger or acquisition. In many countries, there is a legal prerequisite to report intended business concentration to the national competition authority for investigation. This paper investigates decisions made by a competition authority and in addition looks at studies where connected companies are mentioned by the authorities in such decisions. In very few of the investigated decisions, 2.4%, is a third party identified. Our conclusion is that customers and suppliers, if at all effected, are seen as reactive rather than active partners in a concentration. And, the concept supplier or customer relationship is not used.
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