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| 2. |
- Anderson, Helén, et al.
(författare)
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Do Competition Authorities Consider Business Relationships?
- 2012
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Ingår i: Journal of Business-to-Business Marketing. - : Taylor and Francis (Routledge). - 1051-712X .- 1547-0628. ; 19:1, s. 67-92
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Companies engage in business relationships for a variety of reasons, including specialization, product development, and building competitive networks. Research has demonstrated that mergers and acquisitions (Mandamp;As) may challenge ongoing business relationships. The purpose of this article is to investigate whether and how competition authorities consider business relationships when evaluating Mandamp;As. less thanbrgreater than less thanbrgreater thanMethodology: The article uses the documentation from 450 Mandamp;As reported to the Swedish competition authority to capture the way in which an authority evaluates Mandamp;As. The Swedish competition authority evaluation corresponds to other national and international evaluation procedures. less thanbrgreater than less thanbrgreater thanFindings: The findings indicate that the competition authorities neglect an important aspect of business life, namely companies forming business relationships. The competition authorities evaluate Mandamp;As on the basis of risk for price increases, and consequently disregard such issues as heterogeneity in demand and offerings, and values built into existing business relationships. less thanbrgreater than less thanbrgreater thanOriginality/Value/Contribution: The article contributes to research on business relationships through exploring how a public authority deals with such relationships. It also contributes to research on mergers and acquisitions through examining how these activities are evaluated by competition authorities. Furthermore, the article contributes to competition research by reflecting on competition law concerning Mandamp;A regulations in relation to business relationships.
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| 3. |
- Arlinger, Stig, 1939-, et al.
(författare)
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Clinical trial of a digital hearing aid
- 1998
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Ingår i: Scandinavian Audiology. - : Taylor & Francis. - 0105-0397 .- 1940-2872. ; 27:1, s. 51-61
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Tidskriftsartikel (refereegranskat)abstract
- A clinical trial of Oticon DigiFocus hearing aid was performed. The test aid was evaluated on 33 subjects with several years' experience as users of modern analog hearing aids. These aids were used as reference for the 1-month-long trial. The Abbreviated Profile of Hearing Aid Benefit (APHAB) showed a mean difference in benefit with superior ratings for the test aid concerning ease of communication, speech in reverberation and speech in background noise. The subjects' own aids were rated somewhat better concerning aversiveness of sounds, but this difference was not statistically significant. The Gothenburg Profile showed a statistically significant difference between the test aid and the reference aids in favour of the test aid. The difference was not most evident with regard to speech communication and the effects of hearing loss on social interactions. Sound quality ratings concerning clearness were significantly higher for the test aid. Speech recognition thresholds in noise were on average 0.7 dB better for the test aids when tested at speech levels 60 and 75 dB. The difference was statistically significant only at 75 dB. There was significant interaction between general preference and hearing aid type, indicating that overall sound quality was an important factor affecting the general preference for either the test aid or the reference aid. Twenty-three subjects generally preferred the test aid, six preferred their own aid and four stated no difference.
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| 4. |
- Cotgreave, Ian, et al.
(författare)
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Pyriproxifen and microcephaly: an investigation of potential ties to the ongoing "Zika epidemic"
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- As part of the Swetox mission to react to emerging concerns in chemical health and environmental safety, a preliminary litterature investigation was undertaken to gather all readily available scientific information on PPF with respect to safety assessment, in order to better understand potential links between chemical exposure and the devopment of microcephaly in affected areas. Therefore the contents of the report do not constitute an attempt at either questioning the use of existing regulatory data in the manner prescribed by international regulatory proceedures, or as a new risk assessment, based on the scientific information and concepts discussed. Here we report our findings, with particular emphasis on exisiting regulatory information, potential for lack of translation of results from regulatory animal testing to humans, lack of human exposure data and suggestions on plausible mode(s) of action of PPF in human neurodevelopmental adversities such as microcephaly.
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| 5. |
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| 6. |
- Holtström, Johan, 1968-, et al.
(författare)
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Hur nås höga kursutvärderingar? : En studie av korrelationen mellan kursutvärderingar, nedlagd tid och studenters resultat på kurser
- 2009
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Ingår i: Ett år med Bologna - vad har hänt vid LiU?. - Linköping : Linköping University Electronic Press. - 9789173935807 ; , s. 91-103
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Bokkapitel (refereegranskat)abstract
- Kursutvärderingar har blivit allt viktigare. De fyller idag inte enbart en funktion av att utgöra underlag för förbättringar inom utbildningen, utan används även för att utvärdera lärarens insatser. I och med detta skulle det också kunna uppkomma intressen att försöka styra undervisningen för att uppnå höga kursutvärderingar. Diskussioner har bland annat handlat om att höga krav på studenterna påverkar kursutvärderingar negativt (se exempelvis Bjuremark, 2008) samt om det går att få bättre kursutvärderingar genom att ge studenter höga betyg. Syftet med detta papper är att undersöka sambanden mellan det betyg studenterna ger en kurs, deras studiearbetstid och det slutbetyg studenterna erhållit från kursen. Inom Linköpings universitet används det elektroniska kursutvärderingssystemet KURT där man bland annat frågar efter hur studenterna bedömer kursen som helhet på en femgradig skala och där studenterna ska ange genomsnittlig studiearbetstid under kursen. Genom att jämföra dessa värden med studenternas studieresultat avser pappret att besvara följande frågor: Finns det något samband mellan studenternas slutbetyg och det betyg de ger kursen?, Finns det något samband mellan nedlagd studietid och studenternas slutbetyg? Och, finns det något samband mellan nedlagd tid och det betyg studenterna ger kursen? Som underlag för undersökningen använder vi data från 230 kurser inom ekonomi på teknisk fakultet vid Linköpings Universitet. Vi drar slutsatsen att medan det inte finns någon signifikant korrelation mellan nedlagd tid och studieresultat eller mellan kursutvärdering och studieresultat, så finns positiv korrelation mellan nedlagd tid och kursutvärdering. Dessa slutsatser är intressanta att lyfta fram kopplat till diskussioner om kursutvärderingar och studieprestationer, då de indikerar att (i) det inte lönar sig att ge enkla kurser för att få en bra kursutvärdering, (ii) en hög arbetsinsats primärt premierar kursen, medan studenten faktiskt inte når en bättre prestation, och (iii) att ge höga betyg till studenter inte premierar kursutvärderingen.
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| 7. |
- Holtström, Johan, 1968-, et al.
(författare)
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M&A Effects on Procurement
- 2004
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Ingår i: Annual IPSERA Conference,2004.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
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| 9. |
- Odqvist, Lina, et al.
(författare)
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Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
- 2019
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 78:10, s. 1363-1370
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis. A20 is a negative regulator of NF-κB but the role of its DUB domain and related genetic variants remain unclear. We aimed to study the functional effects of A20 DUB-domain alterations in immune cells and understand its link to SLE pathogenesis. Methods: CRISPR/Cas9 was used to generate human U937 monocytes with A20 DUB-inactivating C103A knock-in (KI) mutation. Whole genome RNA-sequencing was used to identify differentially expressed genes between WT and C103A KI cells. Functional studies were performed in A20 C103A U937 cells and in immune cells from A20 C103A mice and genotyped healthy individuals with A20 DUB polymorphism rs2230926. Neutrophil extracellular trap (NET) formation was addressed ex vivo in neutrophils from A20 C103A mice and SLE-patients with rs2230926. Results: Genetic disruption of A20 DUB domain in human and murine myeloid cells did not give rise to enhanced NF-κB signalling. Instead, cells with C103A mutation or rs2230926 polymorphism presented an upregulated expression of PADI4, an enzyme regulating protein citrullination and NET formation, two key mechanisms in autoimmune pathology. A20 C103A cells exhibited enhanced protein citrullination and extracellular trap formation, which could be suppressed by selective PAD4 inhibition. Moreover, SLE-patients with rs2230926 showed increased NETs and increased frequency of autoantibodies to citrullinated epitopes. Conclusions: We propose that genetic alterations disrupting the A20 DUB domain mediate increased susceptibility to SLE through the upregulation of PADI4 with resultant protein citrullination and extracellular trap formation.
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| 10. |
- Simonsson, Bengt, et al.
(författare)
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Intensive treatment and stem cell transplantation in chronic myelogenous leukemia : long-term follow-up
- 2005
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Ingår i: Acta Haematologica. - : S. Karger AG. - 0001-5792 .- 1421-9662. ; 113:3, s. 155-162
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Tidskriftsartikel (refereegranskat)abstract
- In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis, patients not allotransplanted received HU and IFN to keep WBC and platelet counts low. After 6 months patients with Ph-positive cells still present in the bone marrow received 1–3 courses of intensive chemotherapy. Those who became Ph-negative after IFN + HU or after 1–3 chemotherapy courses underwent autologous SCT. Some patients with poor cytogenetic response were allotransplanted with an unrelated donor (URD). IFN + HU reduced the percentage of Ph-positive metaphases in 56% of patients, and 1 patient became Ph-negative. After one or two intensive cytotherapies 86 and 88% had a Ph reduction, and 34 and 40% became Ph-negative, respectively. In patients receiving a third intensive chemotherapy 92% achieved a Ph reduction and 8% became Ph-negative. The median survival after auto-SCT (n = 46) was 7.5 years. The chance of remaining Ph-negative for up to 10 years after autologous SCT was around 20%. The overall survival for allo-SCT RD (n = 91) and URD (n = 28) was almost the same, i.e. ≈60% at 10 years. The median survival for all 251 patients registered was 8 years (historical controls 3.5 years). The role of the treatment schedule presented in the imatinib era is discussed.
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