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Träfflista för sökning "WFRF:(Öhrfelt Annika 1973 ) srt2:(2010-2014);lar1:(lu)"

Sökning: WFRF:(Öhrfelt Annika 1973 ) > (2010-2014) > Lunds universitet

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1.	Brinkmalm-Westman, Ann, 1966, et al. (författare) SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease 2014 Ingår i: Molecular Neurodegeneration. - : Springer Science and Business Media LLC. - 1750-1326. ; 9 Tidskriftsartikel (refereegranskat)abstract Background: Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic proteins such as synaptotagmin and synaptosomal-associated protein 25 (SNAP-25) could be detected in pooled samples of cerebrospinal fluid, however these assays were not sensitive enough for individual samples. Results: We report a new strategy to study synaptic pathology by using affinity purification and mass spectrometry to measure the levels of the presynaptic protein SNAP-25 in cerebrospinal fluid. By applying this novel affinity mass spectrometry strategy on three separate cohorts of patients, the value of SNAP-25 as a cerebrospinal fluid biomarker for synaptic integrity in Alzheimer's disease was assessed for the first time. We found significantly higher levels of cerebrospinal fluid SNAP-25 fragments in Alzheimer's disease, even in the very early stages, in three separate cohorts. Cerebrospinal fluid SNAP-25 differentiated Alzheimer's disease from controls with area under the curve of 0.901 (P < 0.0001). Conclusions: We developed a sensitive method to analyze SNAP-25 levels in individual CSF samples that to our knowledge was not possible previously. Our results support the notion that synaptic biomarkers may be important tools for early diagnosis, assessment of disease progression, and to monitor drug effects in treatment trials.
2.	Hall, Sara, et al. (författare) Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders. 2012 Ingår i: Archives of neurology. - Chicago, IL United States : American Medical Association (AMA). - 1538-3687 .- 0003-9942. ; 69:11, s. 1445-52 Tidskriftsartikel (refereegranskat)abstract To assess the ability of 5 cerebrospinal fluid(CSF) biomarkers to differentiate between common dementia and parkinsonian disorders.
3.	Hansson, Oskar, et al. (författare) Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease. 2014 Ingår i: Alzheimer's research & therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 6:3 Tidskriftsartikel (refereegranskat)abstract The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD), compared with age-matched controls.

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Blennow, Kaj, 1958 (3); Minthon, Lennart (3); Zetterberg, Henrik, ... (3); Hansson, Oskar (3); Londos, Elisabet (2); Hall, Sara (2); visa fler...; Nägga, Katarina (2); Öhrfelt, Annika, 197 ... (2); Wallin, Anders, 1950 (1); Brinkmalm-Westman, A ... (1); Brinkmalm, Gunnar (1); Constantinescu, Radu ... (1); Andreasson, Ulf, 196 ... (1); Vanmechelen, Eugeen (1); Widner, Håkan (1); Holmberg, Björn (1); Hausner, Lucrezia (1); Boström, Fredrik (1); Honer, William G. (1); Frolich, Lutz (1); Majbour, Nour K (1); Surova, Yulia (1); Decraemer, Hilde (1); Nilsson, Christer, 1 ... (1); Öhrfelt Olsson, Anni ... (1); Varghese, Shiji (1); Al-Hayani, Abdulmone ... (1); El-Agnaf, Omar MA (1); visa färre...

Lärosäte: Göteborgs universitet (3); Lunds universitet (3)Ta bort avgränsningen; Linköpings universitet (2)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3)

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