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Träfflista för sökning "WFRF:(Öhrfelt Annika 1973 ) srt2:(2010-2014);pers:(Vanmechelen Eugeen)"

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1.	Hall, Sara, et al. (author) Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders. 2012 In: Archives of neurology. - Chicago, IL United States : American Medical Association (AMA). - 1538-3687 .- 0003-9942. ; 69:11, s. 1445-52 Journal article (peer-reviewed)abstract To assess the ability of 5 cerebrospinal fluid(CSF) biomarkers to differentiate between common dementia and parkinsonian disorders.
2.	Öhrfelt Olsson, Annika, 1973, et al. (author) Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method. 2011 In: Neurochemical research. - : Springer Science and Business Media LLC. - 1573-6903 .- 0364-3190. ; 36:11, s. 2029-2042 Journal article (peer-reviewed)abstract Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are neurodegenerative diseases that are characterized by intra-neuronal inclusions of Lewy bodies in distinct brain regions. These inclusions consist mainly of aggregated α-synuclein (α-syn) protein. The present study used immunoprecipitation combined with nanoflow liquid chromatography (LC) coupled to high resolution electrospray ionization Fourier transform ion cyclotron resonance tandem mass spectrometry (ESI-FTICR-MS/MS) to determine known and novel isoforms of α-syn in brain tissue homogenates. N-terminally acetylated full-length α-syn (Ac-α-syn(1-140)) and two N-terminally acetylated C-terminally truncated forms of α-syn (Ac-α-syn(1-139) and Ac-α-syn(1-103)) were found. The different forms of α-syn were further studied by Western blotting in brain tissue homogenates from the temporal cortex Brodmann area 36 (BA36) and the dorsolateral prefrontal cortex BA9 derived from controls, patients with DLB and PD with dementia (PDD). Quantification of α-syn in each brain tissue fraction was performed using a novel enzyme-linked immunosorbent assay (ELISA).

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Blennow, Kaj, 1958 (2); Zetterberg, Henrik, ... (2); Vanmechelen, Eug... (2)Undo refine; Andersson, K (1); Minthon, Lennart (1); Londos, Elisabet (1); show more...; Aarsland, Dag (1); Wallin, Anders, 1950 (1); Brinkmalm-Westman, A ... (1); Brinkmalm, Gunnar (1); Constantinescu, Radu ... (1); Hansson, Oskar (1); Francis, Paul T (1); Andreasson, Ulf, 196 ... (1); Ballard, Clive (1); Mulugeta, Ezra (1); Widner, Håkan (1); Hall, Sara (1); Nägga, Katarina (1); Holmberg, Björn (1); Öhrfelt, Annika, 197 ... (1); Boström, Fredrik (1); Persson, Rita, 1951 (1); Surova, Yulia (1); Decraemer, Hilde (1); Nilsson, Christer, 1 ... (1); Öhrfelt Olsson, Anni ... (1); Secic, Dzemila (1); show less...

University: University of Gothenburg (2); Linköping University (1); Lund University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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