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Thyroid and islet a...
Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis
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- Jonsdottir, Berglind (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Sweden
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- Larsson, Christer (author)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Lund University, Lund. Sweden
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- Carlsson, Annelie (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Pediatrics, Lund University, Skåne University Hospital, Lund, Sweden
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- Forsander, Gun (author)
- Department of Pediatrics, The Queen Silvia Children´s Hospital, Gothenburg, Sweden
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- Ivarsson, Sten Anders (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Sweden
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Sweden
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- Ludvigsson, Johnny, 1943- (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping
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- Marcus, Claude (author)
- Karolinska Institutet,Karolinska Institute,Division of Pediatrics, Department of Clinical Science, Intervention and Technology Karolinska Institute, Stockholm, Sweden
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- Samuelsson, Ulf, 1951- (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Linköping
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- Örtqvist, Eva (author)
- Karolinska Institutet,Karolinska Institute,Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
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- Elding Larsson, Helena (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Sweden
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(creator_code:org_t)
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- 2016-10-14
- 2017
- English.
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In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 102:4, s. 1277-1285
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Abstract
Subject headings
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- CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics.OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up.SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function. After 5.1-9.5 years disease duration, children treated with thyroxine were identified in the Swedish National Board of Health and Welfare Prescribed Drug Register.RESULTS: Thyroxine had been prescribed to 6% (147/2433; 66% girls). In patients below 5 years, female gender (HR=4.60, p=0.008) and GADA (HR=5.80, p=0.02) were significant predictors. In patients 5-10 years, TPOAb (HR=20.56, p<0.0001), TGAb (HR=3.40, p=0.006) and TSH outside the reference limit (HR=3.64, p<0.001) were predictors while in the 10-15 year olds, TPOAb (HR=17.00, p<0.001) and TSH outside the reference limit (HR=4.11, p<0.001) predicted future thyroxine prescription.CONCLUSION: In addition to TPOAb and TSH, positive GADA tested at the diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children below 5 years of age.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Journal Article
Publication and Content Type
- art (subject category)
- ref (subject category)
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Jonsdottir, Berg ...
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Larsson, Christe ...
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Carlsson, Anneli ...
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Forsander, Gun
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Ivarsson, Sten A ...
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Lernmark, Åke
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Ludvigsson, John ...
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Marcus, Claude
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Örtqvist, Eva
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Elding Larsson, ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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MEDICAL AND HEAL ...
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Lund University
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Linköping University
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Karolinska Institutet