| 1. |
- Niméus, Emma, et al.
(författare)
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Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy
- 2008
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Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 10:2
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionSome patients with breast cancer develop local recurrence after breast-conservation surgery despite postoperative radiotherapy, whereas others remain free of local recurrence even in the absence of radiotherapy. As clinical parameters are insufficient for identifying these two groups of patients, we investigated whether gene expression profiling would add further information.MethodsWe performed gene expression analysis (oligonucleotide arrays, 26,824 reporters) on 143 patients with lymph node-negative disease and tumor-free margins. A support vector machine was employed to build classifiers using leave-one-out cross-validation.ResultsWithin the estrogen receptor-positive (ER+) subgroup, the gene expression profile clearly distinguished patients with local recurrence after radiotherapy (n = 20) from those without local recurrence (n = 80 with or without radiotherapy). The receiver operating characteristic (ROC) area was 0.91, and 5,237 of 26,824 reporters had a P value of less than 0.001 (false discovery rate = 0.005). This gene expression profile provides substantially added value to conventional clinical markers (for example, age, histological grade, and tumor size) in predicting local recurrence despite radiotherapy. Within the ER- subgroup, a weaker, but still significant, signal was found (ROC area = 0.74). The ROC area for distinguishing patients who develop local recurrence from those who remain local recurrence-free in the absence of radiotherapy was 0.66 (combined ER+/ER-).ConclusionA highly distinct gene expression profile for patients developing local recurrence after breast-conservation surgery despite radiotherapy has been identified. If verified in further studies, this profile might be a most important tool in the decision making for surgery and adjuvant therapy.
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| 2. |
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| 3. |
- van de Beek, Jan-Jaap, et al.
(författare)
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A time and frequency synchronization scheme for multiuser OFDM
- 1999
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Ingår i: IEEE Journal on Selected Areas in Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8716 .- 1558-0008. ; 17:11, s. 1900-1914
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Tidskriftsartikel (refereegranskat)abstract
- We present a multiuser synchronization scheme for tracking the mobile's uplink time and frequency offsets. It uses the redundancy introduced by the cyclic prefix and does not need additional pilots. We show performance results of an orthogonal frequency division multiplexing (OFDM)-based radio interface based on universal mobile telecommunication system (UMTS) parameters. For a UMTS-typical mobile channel environment, the performance of a coherent system employing the scheme is virtually indistinguishable from the performance of a perfectly synchronized system. In a differentially modulated system, synchronization errors decrease the system performance by about 0.7 dB compared to a perfectly synchronized system. Index Terms - Communication system, delay estimation, frequency estimation, multicarrier, multiuser system, orthogonal frequency division multiplexing (OFDM), synchronization, universal mobile telecommunication system (UMTS).
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| 4. |
- van de Beek, Jaap, et al.
(författare)
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Synchronization of a TDMA-OFDM frequency hopping system
- 1998
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Ingår i: Pathway to a global wireless revolution. - Piscataway, NJ : IEEE Communications Society. - 0780343204 ; , s. 1290-1294
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a Time Division Multiple Access-Orthogonal Frequency Division Multiplexing (TDMA-OFDM)-based radio interface proposal for the Universal Mobile Telecommunication System (UMTS). We focus on synchronization and present an implementable algorithm for the tracking of the mobiles' time and frequency offsets at the base station in the uplink. This algorithm is based on recently developed estimation methods that use redundancy introduced by the cyclic prefix. A modified Maximum Likelihood (ML) estimator for the Additive White Gaussian Noise (AWGN) channel is used to meet both implementational requirements and performance requirements for frequency-selective fading multiuser environments. Simulation results for a typical UMTS mobile channel environment show that the uncoded symbol error rate of a coherently modulated system using our synchronization scheme is virtually indistinguishable from that of a system with no time and frequency offset.
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| 5. |
- Beldiceanu, Nicolas, et al.
(författare)
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Assistant: Learning and robust decision support system for agile manufacturing environments
- 2021
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Ingår i: IFAC-PapersOnLine. - : Elsevier. ; , s. 641-646
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Konferensbidrag (refereegranskat)abstract
- The European project ASSISTANT will provide a set of AI-based digital twins that helps process engineers and production planners to operate collaborative mixed-model assembly lines based on the data collected from IoT devices and external data sources. Such a tool will help planners to design the assembly line, plan the production, operate the line, and improve process tuning. In addition, the system monitors the line in real-time, ensures that all required resources are available, and allows fast re-planning when necessary. ASSISTANT aims to make cost-effective decisions while ensuring product quality, safety and wellbeing of the workers, and managing the various sources of uncertainties. The resulting digital twin systems will be data-driven, agile, autonomous, collaborative and explainable, safe but reactive.
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| 6. |
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| 7. |
- Blom Johansson, Monica, 1965-, et al.
(författare)
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A multiple-case study of a family-oriented intervention practice in the early rehabilitation phase of persons with aphasia
- 2013
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Ingår i: Aphasiology. - : Informa UK Limited. - 0268-7038 .- 1464-5041. ; 27:2, s. 201-226
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Tidskriftsartikel (refereegranskat)abstract
- Background:Having a family member with aphasia severely affects the everyday life of the significant others, resulting in their need for support and information. Family-oriented intervention programmes typically consist of support, information, and skill training, such as communication partner training (CPT). However, because of time constraints and perceived lack of skills and routines, such programmes, especially CPT, are not common practice among speech-language pathologists (SLPs).Aims:To design and evaluate an early family-oriented intervention of persons with stroke-induced moderate to severe aphasia and their significant others in dyads. The intervention was designed to be flexible to meet the needs of each participant, to emotionally support the significant others and supply them with information needed, to include CPT that is easy to learn and conduct for SLPs, and to be able to provide CPT when the persons with aphasia still have access to SLP services.Methods & Procedures:An evaluative multiple-case study, involving three dyads, was conducted no more than 2 months after the onset of aphasia. The intervention consisted of six sessions: three sessions directed to the significant other (primarily support and information) and three to the dyad (primarily CPT). The intervention was evaluated both qualitatively and quantitatively based on video recordings of conversations and self-assessment questionnaires.Outcomes & Results:The importance of emotional support as well as information about stroke/aphasia was clearly acknowledged, especially by the significant others. All significant others perceived increased knowledge and understanding of aphasia and related issues.Communicative skills (as manifested in the video recordings) showed improvements from pre- to post-intervention.Conclusions:The results corroborate the need for individualised and flexible family-oriented SLP services that are broad in content. Furthermore, the results support the early initiation of such services with recurrent contact. The usefulness of CPT this early in the rehabilitation process was indicated but is yet to be proved.
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| 8. |
- Blom Johansson, Monica, 1965-, et al.
(författare)
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Communication changes and SLP-services according to significant others of persons with aphasia
- 2012
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Ingår i: Aphasiology. - : Informa UK Limited. - 0268-7038 .- 1464-5041. ; 26:8, s. 1005-1028
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Tidskriftsartikel (refereegranskat)abstract
- Background: Significant others are important to persons with aphasia. For several reasons they should be involved in speech-language pathology (SLP) services, including acquiring facilitating communicative strategies and receiving support. In order to further adapt SLP services there is a need to know the perceptions and views of the significant others. Little is known about how they perceive changes in communication as well as received SLP services and in what way they want to be involved in these services.Aims: The study aimed to investigate which communicative changes significant others of persons with aphasia had experienced after a stroke event and to what extent these changes were experienced. A further aim was to describe the significant others’ experiences of SLP services and their motivation to participate in these services. Finally, the significant others’ experiences were compared in terms of sex, age, type of relationship, time since stroke onset, and type and severity of aphasia.Methods & Procedures: An 80-item study-specific questionnaire was answered by 173 significant others of persons with aphasia living throughout Sweden (response rate 69%). Of these, 33% were male and 67% female. Mean age was 64.2 years (range 33–87 years) and 85.5% of the participants were a cohabiting partner to a person with aphasia.Outcomes & Results: A total of 64% of participants perceived their conversations as being less stimulating and enjoyable compared with conversations before stroke onset. Aphasia was considered a substantial or very substantial problem by 64%. The participants took on an increased communicative responsibility, and 70% had changed their communicative behaviour in order to facilitate conversations. A total of 75% (n = 130) had met with the SLP of the person with aphasia. Of those, 63% perceived their own support from SLP services to be adequate; 87% considered language ability training as the most important SLP service. Type and severity of aphasia were especially related to the communicative experiences of the participants and their motivation to be involved in SLP services.Conclusions: The substantial decrease from pre- to post-stroke regarding enjoyment and meaningfulness of conversations suggests the need to further improve SLP services in order to help the people in question communicate at an optimal level. We suggest that clinicians should put more emphasis on explaining the benefits and availability of different kinds of aphasia rehabilitation services, such as functional communication training and communication partner training in addition to language ability training.
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| 9. |
- Blom Johansson, Monica, 1965-, et al.
(författare)
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Self-reported changes in everyday life and health of significant others of people with aphasia : a quantitative approach
- 2022
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Ingår i: Aphasiology. - : Taylor & Francis. - 0268-7038 .- 1464-5041. ; 36:1, s. 76-94
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Tidskriftsartikel (refereegranskat)abstract
- Background: Changes in the everyday life and health of the significant others (SOs) of people living with stroke sequalae have been widely investigated. However, information regarding the frequency of the changes in daily life and the variables most associated with these perceived life changes is limited. Aims: To examine the extent to which SOs of persons with aphasia (PWAs) experience changes in everyday life and health after the stroke event and how they evaluate these changes and to identify which variables are associated with these perceived life changes. Methods & Procedures: A study-specific questionnaire about perceived changes in everyday life and health was completed by 173 SOs of PWAs living in Sweden (response rate 67.8%). The items concerned the SO’s working and financial situation, leisure time and social life, relationship with the PWA, household work and responsibility, and health and quality of life. Outcomes & Results: The everyday life and health of the SOs were greatly affected by the stroke event. The changes the SOs experienced were mainly appraised negatively. The relationships with the PWA and immediate family were least affected by the stroke. The perceived existence and severity of physical, cognitive, and language impairments of the PWA were the variables most strongly associated with the everyday life situation of the participants. The sex and age of the participants and the nature of the relationship with the PWA were only marginally associated with the experience of the situation. Conclusions: SOs’ perceptions of the PWA’s stroke-related disabilities and need for assistance may be a key factor in identifying SOs who may require support and guidance to help them cope with their new life situation.
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| 10. |
- Byrne, James, et al.
(författare)
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A review of cloud computing simulation platforms and related environments
- 2017
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Ingår i: Proceedings of the 7th International Conference on Cloud Computing and Services Science. - : SciTePress. - 9789897582431 ; , s. 679-691
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Konferensbidrag (refereegranskat)abstract
- Recent years have seen an increasing trend towards the development of Discrete Event Simulation (DES) platforms to support cloud computing related decision making and research. The complexity of cloud environments is increasing with scale and heterogeneity posing a challenge for the efficient management of cloud applications and data centre resources. The increasing ubiquity of social media, mobile and cloud computing combined with the Internet of Things and emerging paradigms such as Edge and Fog Computing is exacerbating this complexity. Given the scale, complexity and commercial sensitivity of hyperscale computing environments, the opportunity for experimentation is limited and requires substantial investment of resources both in terms of time and effort. DES provides a low risk technique for providing decision support for complex hyperscale computing scenarios. In recent years, there has been a significant increase in the development and extension of tools to support DES for cloud computing resulting in a wide range of tools which vary in terms of their utility and features. Through a review and analysis of available literature, this paper provides an overview and multi-level feature analysis of 33 DES tools for cloud computing environments. This review updates and extends existing reviews to include not only autonomous simulation platforms, but also on plugins and extensions for specific cloud computing use cases. This review identifies the emergence of CloudSim as a de facto base platform for simulation research and shows a lack of tool support for distributed execution (parallel execution on distributed memory systems).
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