SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Abdellaoui Abdel) ;pers:(Nyholt Dale R.)"

Sökning: WFRF:(Abdellaoui Abdel) > Nyholt Dale R.

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hemani, Gibran, et al. (författare)
  • Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs
  • 2013
  • Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 93:5, s. 865-875
  • Tidskriftsartikel (refereegranskat)abstract
    • Evidence that complex traits are highly polygenic has been presented by population-based genome-wide association studies (GWASs) through the identification of many significant variants, as well as by family-based de novo sequencing studies indicating that several traits have a large mutational target size. Here, using a third study design, we show results consistent with extreme polygenicity for body mass index (BMI) and height. On a sample of 20,240 siblings (from 9,570 nuclear families), we used a within-family method to obtain narrow-sense heritability estimates of 0.42 (SE = 0.17, p = 0.01) and 0.69 (SE = 0.14, p = 6 x 10(-7)) for BMI and height, respectively, after adjusting for covariates. The genomic inflation factors from locus-specific-linkage analysis were 1.69 (SE = 0.21, p = 0.04) for BMI and 2.18 (SE = 0.21, p = 2 x 10(-10)) for height. This inflation is free of confounding and congruent with polygenicity, consistent with observations of ever-increasing genomic-inflation factors from GWASs with large sample sizes, implying that those signals are due to true genetic signals across the genome rather than population stratification. We also demonstrate that the distribution of the observed test statistics is consistent with both rare and common variants underlying a polygenic architecture and that previous reports of linkage signals in complex traits are probably a consequence of polygenic architecture rather than the segregation of variants with large effects. The convergent empirical evidence from GWASs, de novo studies, and within-family segregation implies that family-based sequencing studies for complex traits require very large sample sizes because the effects of causal variants are small on average.
  •  
2.
  • Smith, Jennifer A, et al. (författare)
  • Genome-wide association study identifies 74 loci associated with educational attainment
  • 2016
  • Ingår i: Nature (London). - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 533:7604, s. 539-542
  • Tidskriftsartikel (refereegranskat)abstract
    • Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Magnusson, Patrik K ... (2)
Pedersen, Nancy L (2)
Mangino, Massimo (2)
Willemsen, Gonneke (2)
Nyholt, Dale R. (2)Ta bort avgränsningen
Martin, Nicholas G. (2)
visa fler...
Boomsma, Dorret I. (2)
Franke, Barbara (1)
Jacobsson, Bo, 1960 (1)
Salomaa, Veikko (1)
Perola, Markus (1)
Johannesson, Magnus (1)
Davey Smith, George (1)
Campbell, Harry (1)
Rudan, Igor (1)
Staessen, Jan A (1)
Deloukas, Panos (1)
Lindgren, Karl-Oskar (1)
Pendleton, Neil (1)
Lichtenstein, Paul (1)
Koellinger, Philipp ... (1)
Oskarsson, Sven (1)
Ahluwalia, Tarunveer ... (1)
Waage, Johannes (1)
Amin, Najaf (1)
van Duijn, Cornelia ... (1)
Ingelsson, Erik (1)
Zhao, Wei (1)
Kähönen, Mika (1)
Lehtimäki, Terho (1)
Lee, James J. (1)
Latvala, Antti (1)
Thorleifsson, Gudmar (1)
Thorsteinsdottir, Un ... (1)
Stefansson, Kari (1)
Verweij, Niek (1)
Kaasik, Kadri (1)
Koskinen, Seppo (1)
Nelson, Christopher ... (1)
Gieger, Christian (1)
Strauch, Konstantin (1)
de Geus, Eco J. C. (1)
Henders, Anjali K. (1)
Spector, Tim D. (1)
Kaprio, Jaakko (1)
Samani, Nilesh J. (1)
Karlsson, Robert (1)
Alizadeh, Behrooz Z (1)
Kiemeney, Lambertus ... (1)
Vonk, Judith M (1)
visa färre...
Lärosäte
Uppsala universitet (2)
Karolinska Institutet (2)
Göteborgs universitet (1)
Handelshögskolan i Stockholm (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy