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- Abramov, Viktor, et al.
(författare)
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3-Hom-Lie Algebras Based on σ-Derivation and Involution
- 2020
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Ingår i: Advances in Applied Clifford Algebras. - : Springer. - 0188-7009 .- 1661-4909. ; 30:3
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Tidskriftsartikel (refereegranskat)abstract
- We show that, having a Hom-Lie algebra and an element of its dual vector space that satisfies certain conditions, one can construct a ternary totally skew-symmetric bracket and prove that this ternary bracket satisfies the Hom-Filippov-Jacobi identity, i.e. this ternary bracket determines the structure of 3-Hom-Lie algebra on the vector space of a Hom-Lie algebra. Then we apply this construction to two Hom-Lie algebras constructed on an associative, commutative algebra using σ-derivation and involution, and we obtain two 3-Hom-Lie algebras.
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- Farias, Fabiana H. G., et al.
(författare)
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A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
- 2019
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 27, s. 432-441
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Tidskriftsartikel (refereegranskat)abstract
- Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical presentation and complex etiology involving the interplay between genetic, epigenetic, environmental and hormonal factors. Many common SNPs identified by genome wide-association studies (GWAS) explain only a small part of the disease heritability suggesting the contribution from rare genetic variants, undetectable in GWAS, and complex epistatic interactions. Using targeted re-sequencing of coding and conserved regulatory regions within and around 215 candidate genes selected on the basis of their known role in autoimmunity and genes associated with canine immune-mediated diseases, we identified a rare regulatory variant rs200395694:G > T located in intron 4 of the MEF2D gene encoding the myocyte-specific enhancer factor 2D transcription factor and associated with SLE in Swedish cohorts (504 SLE patients and 839 healthy controls, p = 0.014, CI = 1.1-10). Fisher's exact test revealed an association between the genetic variant and a triad of disease manifestations including Raynaud, anti-U1-ribonucleoprotein (anti-RNP), and anti-Smith (anti-Sm) antibodies (p = 0.00037) among the patients. The DNA-binding activity of the allele was further studied by EMSA, reporter assays, and minigenes. The region has properties of an active cell-specific enhancer, differentially affected by the alleles of rs200395694:G > T. In addition, the risk allele exerts an inhibitory effect on the splicing of the alternative tissue-specific isoform, and thus may modify the target gene set regulated by this isoform. These findings emphasize the potential of dissecting traits of complex diseases and correlating them with rare risk alleles with strong biological effects.
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- Musonda, John
(författare)
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Orthogonal Polynomials, Operators and Commutation Relations
- 2017
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Orthogonal polynomials, operators and commutation relations appear in many areas of mathematics, physics and engineering where they play a vital role. For instance, orthogonal functions in general are central to the development of Fourier series and wavelets which are essential to signal processing. In particular, as demonstrated in this thesis, orthogonal polynomials can be used to establish the L2-boundedness of singular integral operators which is a fundamental problem in harmonic analysis and a subject of extensive investigations. The Lp-convergence of Fourier series is closely related to the Lp-boundedness of singular integral operators. Many important relations in physical sciences are represented by operators satisfying various commutation relations. Such commutation relations play key roles in such areas as quantum mechanics, wavelet analysis, representation theory, spectral theory, and many others.This thesis consists of three main parts. The first part presents a new system of orthogonal polynomials, and establishes its relation to the previously studied systems in the class of Meixner–Pollaczek polynomials. Boundedness properties of two singular integral operators of convolution type are investigated in the Hilbert spaces related to the relevant orthogonal polynomials. Orthogonal polynomials are used to prove boundedness in the weighted spaces and Fourier analysis is used to prove boundedness in the translation invariant case. It is proved in both cases that the two operators are bounded on L2-spaces, and estimates of the norms are obtained.The second part extends the investigation of the boundedness properties of the two singular integral operators to Lp-spaces on the real line, both in the weighted and unweighted spaces. It is proved that both operators are bounded on these spaces and estimates of the norms are obtained. This is achieved by first proving boundedness for L2 and weak boundedness for L1, and then using interpolation to obtain boundedness for the intermediate spaces. To obtain boundedness for the remaining spaces, duality is used in the translation invariant case, while the weighted case is partly based on the methods developed by M. Riesz in his paper of 1928 for the conjugate function operator.The third and final part derives simple and explicit formulas for reordering elements in an algebra with three generators and Lie type relations. Centralizers and centers are computed as an example of an application of the formulas.
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- Musonda, John, 1981-
(författare)
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Reordering in Noncommutative Algebras, Orthogonal Polynomials and Operators
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main object studied in this thesis is the multi-parametric family of unital associative complex algebras generated by the element $Q$ and the finite or infinite set $\{S_j\}_{j\in J}$ of elements satisfying the commutation relations $S_jQ=\sigma_j(Q)S_j$, where $\sigma_j$ is a polynomial for all $j\in J$. A concrete representation is given by the operators $Q_x(f)(x)=xf(x)$ and $\alpha_{\sigma_j}(f)(x)=f(\sigma_j(x))$ acting on polynomials or other suitable functions. The main goal is to reorder arbitrary elements in this family and some of its generalizations, and to study properties of operators in some representing operator algebras, including their connections to orthogonal polynomials. For $J=\{1\}$ and $\sigma(x)=x+1$, the above commutation relations reduce to the famous classical Heisenberg--Lie commutation relation $SQ-QS=S$. Reordering an element in $S$ and $Q$ means to bring it, using the commutation relation, into a form where all elements $Q$ stand either to the left or to the right. For example, $SQ^2=Q^2S+2QS+S$. In general, one can use the commutation relation $SQ-QS=S$ successively and transform for any positive integer $n$ the element $SQ^n$ into a form where all elements $Q$ stand to the left. The coefficients which appear upon reordering in this case are the binomial coefficients. General reordering formulas for arbitrary elements in noncommutative algebras defined by commutation relations are important in many research directions, open problems and applications of the algebras and their operator representations. In investigation of the structure, representation theory and applications of noncommutative algebras, an important role is played by the explicit description of suitable normal forms for noncommutative expressions or functions of generators. Further investigation of the operator representations of the commutation relations by difference type operators on Hilbert function spaces leads to interesting connections to functional analysis and orthogonal polynomials. This thesis consists of two main parts. The first part is devoted to the multi-parametric family of algebras introduced above. General reordering formulas for arbitrary elements in this family are derived, generalizing some well-known results. As an example of an application of the formulas, centralizers and centers are computed. Some operator representations of the above algebras are also described, including considering them in the context of twisted derivations. The second part of this thesis is devoted to a special representation of these algebras by difference operators associated with action by shifts on the complex plane. It is shown that there are three systems of orthogonal polynomials of the class of Meixner--Pollaczek polynomials that are connected by these operators. Boundedness properties of two singular integral operators of convolution type connected to these difference operators are investigated in the Hilbert spaces related to these systems of orthogonal polynomials. Orthogonal polynomials are used to prove boundedness in the weighted spaces and Fourier analysis is used to prove boundedness in the translation invariant case. It is proved in both cases that the two operators are bounded on the $L^2$-spaces and estimates of the norms are obtained. This investigation is also extended to $L^p$-spaces on the real line where it is proved again that the two operators are bounded.
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