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Preoperative serum ...
Preoperative serum levels of follicle stimulating hormone (FSH) and prognosis in invasive breast cancer
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Eskelinen, M. (author)
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Nordén, T. (author)
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Lindgren, A. (author)
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Wide, L. (author)
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Holmberg, Lars (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal Surgery
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 30:5, s. 495-500
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- AIMS: We investigated the association between preoperative serum levels of follicle stimulating hormone (FSH) and the prognosis in women with invasive breast cancer. METHODS: Serum levels of FSH were measured in 182 premenopausal and 581 peri- or postmenopausal women with invasive breast cancer. They were followed for a mean time of 84 months. The study endpoint was death from breast cancer (182 events). Analyses were stratified on menopausal status. RESULTS: None of the estimates showed a statistically significant result. In both pre- and postmenopausal women there was a nominally higher probability of survival with a higher FSH level. Point estimates in multivariate analysis incorporating age, tumour diameter, axillary lymph status, estrogen and progesterone receptor content and year of treatment indicated a stronger association with FSH levels in premenopausal than postmenopausal women (relative hazard 0.63 or 0.85, respectively in the highest compared with the lowest quartile). CONCLUSION: We did not find any statistically significant association between preoperative serum level of FSH and prognosis. Today, FSH is not a clinical target for intervention or a clinically useful prognostic factor and the results of clinical studies up to date can only be used for motivation of further experimental laboratory research.
Keyword
- Adult
- Aged
- Breast Neoplasms/*blood/*diagnosis/epidemiology
- Comparative Study
- Female
- Follicle Stimulating Hormone/*blood
- Follow-Up Studies
- Humans
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Postmenopause/blood
- Premenopause/blood
- Preoperative Care
- Prognosis
- Prospective Studies
- Risk Factors
- Statistics
- Survival Analysis
- Sweden/epidemiology
- Tumor Markers; Biological/*blood
- Women's Health
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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