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Androgen deprivation therapy for prostate cancer and risk of dementia

Robinson, D. (författare)
Ryhov Hosp, Dept Urol, Jonkoping, Sweden
Garmo, Hans (författare)
Regional Cancer Centre Uppsala Örebro, Uppsala university hospital, Sweden;Kings Coll London, TOUR, Sch Canc & Pharmaceut Sci, London, England
Van Hemelrijck, M. (författare)
Kings Coll London, TOUR, Sch Canc & Pharmaceut Sci, London, England
visa fler...
Damber, Jan-Erik, 1949 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Univ Gothenburg, Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden
Bratt, Ola, 1963 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Univ Gothenburg, Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden
Holmberg, L. (författare)
Kings Coll London, TOUR, Sch Canc & Pharmaceut Sci, London, England
Wahlund, L. O. (författare)
Karolinska Institutet
Stattin, Pär (författare)
Uppsala universitet,Urologkirurgi
Adolfsson, J. (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
2019-02-06
2019
Engelska.
Ingår i: Bju International. - : Wiley. - 1464-4096 .- 1464-410X. ; 124:1, s. 87-92
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objectives To study whether androgen deprivation therapy (ADT), the mainstay treatment for advanced and disseminated prostate cancer, is associated with risk of dementia. Methods Risk of dementia in men with prostate cancer primarily managed with ADT or watchful waiting (WW) in the Prostate Cancer Database Sweden, PCBaSe, was compared with that in prostate cancer-free men, matched on birth year and county of residency. We used Cox regression to calculate the hazard ratios (HRs) for Alzheimer's and non-Alzheimer's dementia (vascular dementia, dementia secondary to other diseases or unspecified dementias) for different types and duration of ADT and oral antiandrogens (AAs) as well as for men managed with WW. Results A total of 25 967 men with prostate cancer and 121 018 prostate cancer-free men were followed for a median of 4 years. In both groups 6% of the men were diagnosed with dementia. In men with prostate cancer, gonadotropin-releasing hormone agonist treatment ( HR 1.15, 95% confidence interval [CI] 1.07-1.23) and orchiectomy (HR 1.60, 95% CI 1.32-1.93) were associated with an increased risk of dementia, as compared to no treatment in prostate cancer-free men; however, this increase in risk was only observed for non-Alzheimer's dementia and occurred from year 1-4 after start of ADT. No increase in risk for any type of dementia was observed for men treated with AAs or for men on WW. Conclusion This population-based cohort study does not support previous observations of an increased risk of Alzheimer's dementia for men on ADT; however, there was a small increase in risk of non-Alzheimer's dementia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

androgen deprivation therapy
dementia
#ProstateCancer
#PCSM
#ADT
#Dementia
free testosterone
alzheimers-disease
cognitive function
cohort
profile
men
association
register
sweden
Urology & Nephrology
arlson me
1987
journal of chronic diseases
v40
p373
androgen deprivation therapy

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