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Commonly used estim...
Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates
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- Björk, Jonas (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Andersson, Tomas (författare)
- Karolinska Institutet,Stockholm County Council,Karolinska Institute
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- Ahlbom, Anders (författare)
- Karolinska Institutet,Stockholm County Council,Karolinska Institute
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(creator_code:org_t)
- 2019-10-22
- 2019
- Engelska.
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 34:11, s. 987-992
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Abstract
Ämnesord
Stäng
- The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability coefficients. In this paper, we demonstrate why such quantifications are generally as problematic as bad luck estimates. We stress the differences in calculation and interpretation between the heritability coefficient and the population attributable fraction, the estimated fraction of all disease events that would not occur if an intervention could successfully prevent the excess genetic risk. We recommend using the population attributable fraction when communicating results regarding the genetic contribution to disease, as this measure is both more relevant from a public health perspective and easier to understand.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Epidemiology
- Etiologic fraction
- Genetic studies
- Public health
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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