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1.	Stegemann-Koniszewski, S, et al. (author) TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection 2013 In: Journal of innate immunity. - : S. Karger AG. - 1662-8128 .- 1662-811X. ; 5:1, s. 84-96 Journal article (peer-reviewed)abstract Increased risk for bacterial superinfections substantially contributes to the mortality caused by influenza A virus (IAV) epidemics. While the mechanistic basis for this lethal synergism is still insufficiently understood, immune modulation through the viral infection has been shown to be involved. Since the pattern-recognition receptor (PRR) toll-like receptor 7 (TLR7) is a major sensor for the viral genome, we studied how IAV recognition by TLR7 influences the development of secondary pneumococcal infection. In a mouse model of IAV, TLR7-deficient hosts induced a potent antiviral response and showed unchanged survival. In secondary pneumococcal infection during acute influenza, TLR7ko mice showed a fatal outcome similar to wild-type (WT) hosts, despite significantly delayed disease progression. Also, when bacterial superinfection occurred after virus clearance, WT and TLR7-deficient hosts showed similar mortality, even though we found the phagocytic activity of alveolar macrophages isolated from IAV-pre-infected hosts to be enhanced in TLR7ko over WT mice. Thus, we show that a virus-sensing PRR modulates the progression of secondary pneumococcal infection following IAV. However, the fatal overall outcome in WT as well as TLR7ko hosts suggests that processes distinct from TLR7-triggering override the contribution of this single PRR.
2.	Albiger, B, et al. (author) Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection 2007 In: Cellular microbiology. - : Hindawi Limited. - 1462-5814 .- 1462-5822. ; 9:3, s. 633-644 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Henriques-Normar... (2)Undo refine; Akira, S (2); Normark, S (1); Dahlberg, S (1); Albiger, B (1); Sandgren, A (1); show more...; Katsuragi, H (1); Beiter, K (1); Wartha, F (1); Gunzer, M (1); Weiss, S (1); Stegemann-Koniszewsk ... (1); Bruder, D (1); Orrskog, S (1); Pasche, B (1); Lienenklaus, S (1); Gruber, AD (1); Gereke, M (1); Bader, SR (1); show less...

University: Karolinska Institutet (2)

Language: English (2)

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