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- Hellgren, Gunnel, 1961, et al.
(author)
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The growth hormone receptor exon 3-deleted/full-length polymorphism and response to growth hormone therapy in prepubertal idiopathic short children
- 2015
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In: Growth Hormone & IGF Research. - : Elsevier BV. - 1096-6374 .- 1532-2238. ; 25:3, s. 127-135
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Journal article (peer-reviewed)abstract
- Objective: The primary aim of the study was to evaluate d3-GHR as a possible cause of increased GH sensitivity in children with delayed infancy-childhood transition (DICT). The secondary aim was to investigate the impact of the GHR exon 3 deleted/full-length (d3/f1) polymorphism on GH treatment response in prepubertal children classified as having idiopathic short stature (ISS). Design: Study subjects included 167 prepubescent longitudinally followed children classified as having ISS. Children were randomized to standard-dose GH treatment (33 mu g kg(-1) day(-1)), to double-dose treatment (67 mu g kg(-1) day(-1)), or to an untreated control group. Growth and metabolic outcome were evaluated at birth (n = 166), after one year of treatment (n = 59) and at adult height (n = 145). Genotyping of the GHR d3/f1 polymorphism was performed using TaqMan SNP genotyping of tagSNP rs6873545. Results: Birth and early growth data did not reach the predetermined level of statistical significance for difference between genotypes. Growth and IGF-1 response after one year of GH treatment did not differ between genotypes. IGFBP-3(SDS) was higher in untreated d3-GHR carriers than in untreated fl/fl individuals, whereas there was insufficient evidence for higher IGFBP-3(SDS) in treated d3-GHR carriers. Genotype did not explain the growth response to treatment, and no differences in height(SDS), height gain, or difference in height to midparental height(SDS) between genotype groups were found at adult height. Conclusion: The common GHR d3/fl polymorphism is probably not a cause of DICT in children with ISS, and our results do not suggest that the d3-GHR genotype is associated with increased sensitivity to GH in children with ISS.
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| 2. |
- Jarrett, O. O., et al.
(author)
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Penile size in healthy Nigerian newborns : country-based reference values and international comparisons
- 2014
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 103:4, s. 442-446
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Journal article (peer-reviewed)abstract
- AimTo establish normal reference values for penile size in Nigerian newborn boys and to compare those values with standards from other populations. MethodsA total number of 261 healthy newborn boys delivered at gestational ages of 28weeks or more were enrolled in the study. Penile lengths and widths were measured within 72h of birth. ResultsThe mean (SD) penile length in the 261 Nigerian males studied was 3.4 +/- 0.48cm, while the mean mid-shaft diameter was 1.2 +/- 0.14cm. Compared with data from other populations, Nigerian newborn boys had similar penile sizes to those reported for US Caucasian boys (mean 3.4cm), but significantly greater penile sizes than those reported for boys from China and Hong Kong (mean 3.0 and 3.1cm, respectively; both p<0.001). There was a slight, but significant, difference in size between Nigerian and Malaysian boys, with Malaysian boys having greater penile sizes (mean 3.5cm; p<0.05). ConclusionA Nigerian newborn with a penile length of <2.39cm can be considered to have a micropenis.
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