| 1. |
- Caretta, Martina Angela, et al.
(författare)
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Water
- 2022
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Ingår i: Climate Change 2022: Impacts, Adaptation and Vulnerability : Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change - Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change.
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Callaghan, Terry V., et al.
(författare)
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Changing snow cover and its impacts
- 2011
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Ingår i: Snow, Water, Ice and Permafrost in the Arctic (SWIPA). - Oslo : Arctic Monitoring and Assessment Programme. - 9788279710714 ; , s. 4:1-4:58
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Bokkapitel (refereegranskat)
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| 3. |
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| 4. |
- Schmidt, Florian M., et al.
(författare)
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Optical spectroscopy
- 2020. - 2
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Ingår i: Breathborne biomarkers and the human volatilome. - : Elsevier. - 9780128199671 - 9780128223970 ; , s. 221-238
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Optical spectroscopy is widely used for quantitative detection of small molecules in complex gas matrices. Employing a laser as a light source enables highly sensitive, selective, and accurate trace gas analysis in exhaled breath without the need for frequent calibration. Many volatile species with direct physiological relevance, especially small molecules such as CO2, CO, NO, CH4, NH3, HCN, C2H4, and their isotopoloques, can be measured with high time resolution using compact optical analyzers. Thus, laser-based sensors are an important complement to other analytical platforms and contribute to establishing breath gas analysis in the clinical practice. This chapter introduces the basics of optical spectroscopy and describes the most relevant techniques currently used in the field, such as nondispersive, laser absorption, and photoacoustic spectroscopy. Successful applications of optical methods are presented, and the future prospects are discussed. Owing to the advent of novel light sources, such as quantum cascade lasers and optical frequency combs, spectroscopy will continue to play a significant role in breath gas analysis.
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| 5. |
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| 6. |
- Bruni, G., et al.
(författare)
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PMT saturation due to large dynamic range
- 2018
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Ingår i: GSI-FAIR Scientific Report 2017. - 2625-8692 .- 2625-8692. ; :1, s. 161-161
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
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| 9. |
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| 10. |
- Pietras, Alexander, et al.
(författare)
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The HIF-2alpha-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization.
- 2010
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Ingår i: Diverse Effects of Hypoxia on Tumor Progression. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 0070-217X. - 9783642133299 - 9783642133282 ; 345, s. 1-20
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Bokkapitel (refereegranskat)abstract
- Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxia inducible transcription factors, HIF-1 and HIF-2. Tumor hypoxia and high HIF protein levels are frequently associated with aggressive disease. In recent years, high tumor cell levels of HIF-2 and the oxygen sensitive subunit HIF-2alpha have been associated with unfavorable disease and shown to be highly expressed in tumor stem/initiating cells originating from neuroblastoma and glioma, respectively. In these cells, HIF-2 is active under nonhypoxic conditions as well, creating a pseudo-hypoxic phenotype with clear influence on tumor behavior. Neuroblastoma tumor initiating cells are immature with a neural crest-like phenotype and downregulation of HIF-2alpha in these cells results in neuronal sympathetic differentiation and the cells become phenotypically similar to the bulk of neuroblastoma cells found in clinical specimens. Knockdown of HIF-2alpha in neuroblastoma and glioma tumor stem/initiating cells leads to reduced levels of VEGF and poorly vascularized, highly necrotic tumors. As high HIF-2alpha expression further correlates with disseminated disease as demonstrated in neuroblastoma, glioma, and breast carcinoma, we propose that targeting HIF-2alpha and/or the pseudo-hypoxic phenotype induced by HIF-2 under normoxic conditions has great clinical potential.
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