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- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 2. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Ocaya, Pauline, 1980-
(författare)
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Retinoid metabolism and signalling in vascular smooth muscle cells
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Smooth muscle cells (SMCs) play a major role in cardiovascular diseases. In advanced atherosclerosis, blood flow is impaired due to reduced luminal diameter. Percutaneous vascular interventions, including balloon angioplasty and stent-application are commonly used for the re-establishment of luminal size and improvement of tissue perfusion. However, the benefit of vascular interventions is hampered by re-stenosis. The molecular basis of re-stenosis is not fully elucidated and so far, no successful treatment is clinically available. Re-stenosis, which is proposed to be a response to mechanical injury, involves the activation of multiple processes including inflammation, SMC migration and proliferation, and is characterized by vessel remodelling and intimal hyperplasia. Retinoids have been shown to regulate several processes activated at site of vascular injury including inflammation, SMC migration and proliferation, and have been demonstrated to inhibit SMC proliferation and reduce intimal hyperplasia. Thus, retinoids are potential candidates in the treatment of certain vascular disorders. Retinoid metabolism is complex and involves a repertoire of proteins including retinoic acid synthesizing and catabolizing enzymes. The purpose of this study was to investigate retinoid metabolism in vascular cells, more specifically to find key points in the regulation of retinoid metabolism in vascular SMCs and atherosclerotic lesions. We demonstrate that different phenotypes of SMCs exhibit differences in retinoid metabolism, which suggests a link between retinoid metabolism and the SMC phenotype. Vascular SMCs and atherosclerotic lesions expressed cytochrome P450 isoform 26 (CYP26) enzymes, which are involved in retinoid catabolism. Our studies reveal the presence of a negative feedback loop, in which retinoids induce its inactivation by inducing CYP26 expression in vascular SMCs and atherosclerotic lesions. Moreover, inhibition of CYP26 potently blocked retinoid catabolism and resulted in retinoid-like effects in SMCs, indicating that CYP26 is an important endogenous modulator of retinoid metabolism in vascular cells. In atherosclerotic lesions and vascular SMCs, decreased retinoid catabolism and hence, increased retinoid availability, resulted in increased expression of retinoid-responsive genes. Since retinoids reduce intimal hyperplasia in animal models, our studies suggest that CYP26 inhibitors may provide an alternative to exogenous retinoid administration. Thus, CYP26 inhibitors may offer a new therapeutic approach to vascular proliferative disorders.
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| 10. |
- Imbesi, S, et al.
(författare)
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Functional decline and quality of life in the inpatient oncology setting.
- 2013
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Ingår i: APA Conference 2013. - : Australian Physiotherapy Association. ; , s. 3-3
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Question: What effect does inpatient oncology treatment have on patient quality of life and physical functioning? Does recent weight loss associated with inferior physical functioning in patients admitted for inpatient oncology treatment? What are the implications for physiotherapy practice?Design: Prospective observational cohort studyParticipants: Thirty-two patients receiving inpatient oncology treatment.Outcome Measures: EORTC-30, SF8, isometric muscle strength, 30 second arm curl, sit to stand and timed up and go.Results: The EORTC-30 and SF-8 physical functioning and fatigue scales as well as timed up and go and sit to stand functional measures showed a trend of weekly decline in performance during inpatient oncology treatment but changes were not statistically different from baseline. Emotional and cognitive functioning and the 30 second arm curl however improved compared to baseline (p = <0.05). Social functioning showed a decline at two weeks compared to baseline (p = <0.05). Bivariate correlation analysis of baseline data showed sit to stand (r = -0.52), isometric knee extension (r = -0.39) and foot dorsiflexion (r = -0.42) strength to be significantly negatively associated with weight loss (p = <0.05).Conclusion: Despite non-significant decline in physical functioning during inpatient oncology treatment, comparison to healthy aged matched normative values showed obvious inferiority in quality of life and physical functioning at time of admission to hospital.Key Practice Points:• Physiotherapy management of patients in the inpatient oncology setting should focus on preventing decline in physical and social functioning.• Patients with greater reported weight loss may be more prone to larger declines in physical functioning in the inpatient oncology setting.
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