SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Allison Matthew) ;lar1:(ltu)"

Sökning: WFRF:(Allison Matthew) > Luleå tekniska universitet

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Allison, James, et al. (författare)
  • Analytical target cascading in aircraft design
  • 2006
  • Ingår i: 44th AIAA Aerospace Sciences Meeting and Exhibit. - Reston, Va. : American Institute of Aeronautics and Astronautics, AIAA. - 1563477955 ; , s. 16112-16120
  • Konferensbidrag (refereegranskat)abstract
    • Analytical Target Cascading (ATC) is a product development tool that computes component design specifications such that the final system design is consistent and meets design targets. ATC is useful for complex product design that must be approached by decomposition, and facilitates concurrent design activities. While ATC has been applied successfully to automotive design, this article introduces the application of ATC to aircraft design, and discusses how it can be congruent with current design practice. ATC is used to solve an aircraft design problem where several flight regimes are considered separately. ATC can be used to balance low-fidelity system analysis and component-level multidisciplinary design optimization (MDO) activities. Finally, ATC may be used to coordinate overall aircraft design, with MDO employed to solve tightly coupled disciplinary problems that exist within ATC elements.
  •  
2.
  • Yaghootkar, Hanieh, et al. (författare)
  • Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
  • 2020
  • Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:12, s. 2806-2818
  • Tidskriftsartikel (refereegranskat)abstract
    • Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy