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Sökning: WFRF:(Anckarsater H)

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  • [1]234567...8Nästa
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1.
  • Bromander, Sara, et al. (författare)
  • Cerebrospinal fluid insulin during non-neurological surgery.
  • 2010
  • Ingår i: J Neural Transm (Vienna, Austria:1996). - 1435-1463. ; 117:10, s. 1167-70
  • Tidskriftsartikel (refereegranskat)abstract
    • Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.
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2.
  • Magnusson, Patrik, et al. (författare)
  • The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments.
  • 2013
  • Ingår i: Twin research and human genetics : the official journal of the International Society for Twin Studies. - 1832-4274. ; 16:1, s. 317-29
  • Tidskriftsartikel (refereegranskat)abstract
    • The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.
3.
  • Nilsson, Thomas, et al. (författare)
  • Neurochemical measures co-vary with personality traits: Forensic psychiatric findings replicated in a general population sample.
  • 2010
  • Ingår i: Psychiatry research. - 0165-1781. ; 178:3, s. 525-530
  • Tidskriftsartikel (refereegranskat)abstract
    • Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum concentrations of beta-trace protein (beta TP) (as markers for blood-brain barrier (BBB) permeability), to CSF/serum albumin ratios between the dopamine and serotonin metabolites homovanillic acid (HVA)/5-hydroxyindoleacetic acid (HIM) and to CSF and serum ratios between activated thyroid hormone (T3) and its precursor T4. Serum beta TP concentrations correlated with CSF/serum albumin ratios (P=0.018), but not with preoperative serum creatinine concentrations. Serum beta TP correlated significantly with Monotony Avoidance and Impulsiveness: CSF HVA/5-HIAA ratios with Irritability and low Cooperativeness. The beta TP is a potential serum marker for the integrity of the BBB that does not necessitate lumbar puncture. Thyroid hormones did not correlate with personality traits. As reported in forensic psychiatric patients, aggressive, unempathic personality traits were thus associated with increased dopaminergic activity in relation to the serotonergic activity and impulsivity to increased BBB permeability also in a general population group. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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4.
  • Anckarsater, R., et al. (författare)
  • Cerebrospinal fluid protein reactions during non-neurological surgery.
  • 2007
  • Ingår i: Acta neurologica Scandinavica. - 0001-6314. ; 115:4, s. 254-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.
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9.
  • Bromander, Sara, et al. (författare)
  • Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study.
  • 2012
  • Ingår i: Journal of neuroinflammation. - 1742-2094. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • ABSTRACT: Background: Surgery launches an inflammatory reaction in the body, as seen through increased peripheral levels of cytokines and cortisol. However, less is known about perioperative inflammatory changes in the central nervous system (CNS). Our aim was to compare inflammatory markers in serum and cerebrospinal fluid (CSF) before and after surgery and evaluate their association with measures of blood–brain barrier (BBB) integrity. Methods: Thirty-five patients undergoing knee arthroplastic surgery with spinal anesthesia had CSF and serum samples drawn before, after and on the morning following surgery. Cytokines and albumin in serum and CSF and cortisol in CSF were assessed at all three points. Results: Cytokines and cortisol were significantly increased in serum and CSF after surgery (Ps <0.01) and CSF increases were greater than in serum. Ten individuals had an increased cytokine response and significantly higher CSF/serum albumin ratios (Ps <0.01), five of whom had albumin ratios in the pathological range (>11.8). Serum and CSF levels of cytokines were unrelated, but there were strong correlations between CSF IL-2, IL-10 and IL-13, and albumin ratios (Ps <0.05) following surgery. Conclusion: Cytokine increases in the CNS were substantially greater than in serum, indicating that the CNS inflammatory system is activated during peripheral surgery and may be regulated separately from that in the peripheral body. CSF cytokine increase may indicate sensitivity to trauma and is linked to BBB macromolecular permeability.
10.
  • Jonsson, Lina, et al. (författare)
  • Association between asmt and autistic-like traits in children from a swedish nationwide cohort.
  • 2014
  • Ingår i: Psychiatric Genetics. - 0955-8829 .- 1473-5873. ; 24:1, s. 21-27
  • Tidskriftsartikel (refereegranskat)abstract
    • Persons with autism spectrum disorders (ASDs) often display low levels of melatonin, and it has been suggested that this decrease may be due to low activity of the acetylserotonin O-methyltransferase (ASMT), the last enzyme in the melatonin synthesis pathway. Moreover, genetic variants in ASMT have been associated with autism, as well as with low ASMT activity and melatonin levels, suggesting that the low ASMT activity observed in autism may partly be due to variation within the ASMT gene. In this study, we present a symptom-based approach to investigate possible associations between ASMT and autistic-like traits (ALTs) in the general population. To this end, continuous measures of ALTs were assessed in a nationally representative twin cohort (n=1771) from Sweden and six Single Nucleotide Polymorphisms (SNP) and a duplication of exon 2 to 8 in ASMT were genotyped. Our results show a nominally significant association, in girls, between one SNP (rs5949028) in the last intron of ASMT and social interaction impairments. No significant association, however, was observed with traits related to language impairment or restricted and repetitive behavior. In conclusion, our results support the possible involvement of the ASMT gene in ASDs and our finding that only one of three traits shows association suggests that genetic research may benefit from taking a symptom-specific approach to identify genes involved in autism psychopathology.
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