| 1. |
- Adler, Jan-Olof, et al.
(författare)
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A broad range tagging spectrometer for the MAX-laboratory
- 1997
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0167-5087. ; 388:1-2, s. 17-26
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Tidskriftsartikel (refereegranskat)abstract
- A broad range tagging spectrometer together with a new beam transport system for photonuclear experiments at the MAX-laboratory in Lund is described. The spectrometer consists of a quadrupole followed by an Elbek-type dipole and has a large momentum acceptance. It can produce both polarized and unpolarized tagged photons in the energy range 10–80 MeV with an energy resolution of about 300 keV.
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| 2. |
- Andersson, Daniel, 1977, et al.
(författare)
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Supply Voltage Drop Study Considering On-Chip Self Inductance of a 32-bit Processor's Power Grid
- 2009
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Ingår i: 2009 IEEE Workshop on Signal Propagation on Interconnects, SPI '09; Strasbourg; France; 12 May 2009 through 15 May 2009. - 9781424444892
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Konferensbidrag (refereegranskat)abstract
- Conventional IR drop analysis suggests that on-chip inductive effects can be neglected when estimating supply voltage drops. We present a supply voltage drop analysis for a commercial 32-bit application processor. Our power grid model uses a backbone RL extracted netlist of the processor's power grid, complemented with capacitances from the processor design and a current signature defined by the worst-case switching test vector, located in the power-up sequence of the processor. Our circuit simulations show that on-chip self inductance makes the actual supply voltage drop deviate by more than 55% and 25% from the ∼6% and ∼8% drop, respectively, of nominal supply voltage that a conventional IR power grid model yields.
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| 3. |
- Andersson, Helena, 1976-
(författare)
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Gotländska stenåldersstudier : Människor och djur, platser och landskap
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals mainly with the Middle Neolithic period (ca. 3200-2300 BC) on the island of Gotland in the Baltic Sea. The aim is to deepen the understanding of how the islanders related to their surroundings, to the landscape, to places, to objects, to animals and to humans, both living and dead. The archaeological material is studied downwards and up with a focus on practices, especially the handling and deposition of materials and objects in graves, within sites and in the landscape. The study is comparative and the Middle Neolithic is described in relation to the Early Neolithic and the Mesolithic period on the island.From a long term perspective the island is presented as a region where strong continuity can be identified, regarding both way of life and economy. In contrast, substantial changes did occur through time regarding the islander’s conceptions of the world and of social relations. This in turn affected the way they looked upon the landscape, different sites and animals, as well as other human beings. During the Mesolithic, the islanders first saw it as possible to create their world, their micro-cosmos, wherever they were, and they saw themselves as living in symbiosis with seals. With time, though, they started to relate, to connect and to identify themselves with the island, its landscape and its material, with axe sites and a growing group identity as results. The growing group identity culminated during the Early Neolithic with a dualistic conception of the world and with ritualised depositions in border zones.The Middle Neolithic is presented as a period when earlier boundaries were dissolved. This concerned, for example, boundaries towards the world around the islanders and they were no longer keeping themselves to their own sphere. At the same time individuals became socially important. It became accepted and also vital to give expression to personal identity, which was done through objects, materials and animals. Despite this, group identity continued to be an important part in their lives. This is most evident through the specific Pitted Ware sites, where the dead were also treated and buried. These places were sites for ritual and social practices, situated in visible, central and easy accessible locations, like gates in and out of the islands’ different areas. The dead were very important for the islanders. In the beginning of MN B they started to adopt aspects from the Battle Axe culture, but they never embraced Battle Axe grave customs. Instead they held on to the Pitted Ware way of dealing with the dead and buried, and to the Pitted Ware sites, through the whole period, with large burial grounds as a result.
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| 4. |
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| 5. |
- Chapman, Henry N, et al.
(författare)
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Femtosecond X-ray protein nanocrystallography.
- 2011
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 470:7332, s. 73-7
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Tidskriftsartikel (refereegranskat)abstract
- X-ray crystallography provides the vast majority of macromolecular structures, but the success of the method relies on growing crystals of sufficient size. In conventional measurements, the necessary increase in X-ray dose to record data from crystals that are too small leads to extensive damage before a diffraction signal can be recorded. It is particularly challenging to obtain large, well-diffracting crystals of membrane proteins, for which fewer than 300 unique structures have been determined despite their importance in all living cells. Here we present a method for structure determination where single-crystal X-ray diffraction 'snapshots' are collected from a fully hydrated stream of nanocrystals using femtosecond pulses from a hard-X-ray free-electron laser, the Linac Coherent Light Source. We prove this concept with nanocrystals of photosystem I, one of the largest membrane protein complexes. More than 3,000,000 diffraction patterns were collected in this study, and a three-dimensional data set was assembled from individual photosystem I nanocrystals (∼200 nm to 2 μm in size). We mitigate the problem of radiation damage in crystallography by using pulses briefer than the timescale of most damage processes. This offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage.
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| 6. |
- Håkansson, Petra, et al.
(författare)
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Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation.
- 2008
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Ingår i: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 47:4, s. 267-275
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Tidskriftsartikel (refereegranskat)abstract
- Philadelphia (Ph) chromosome-positive leukemia is characterized by the BCR/ABL1 fusion protein that affects a wide range of signal transduction pathways. The knowledge about its downstream target genes is, however, still quite limited. To identify novel BCR/ABL1-regulated genes we used global gene expression profiling of several Ph-positive and Ph-negative cell lines treated with imatinib. Following imatinib treatment, the Ph-positive cells showed decreased growth, viability, and reduced phosphorylation of BCR/ABL1 and STAT5. In total, 142 genes were identified as being dependent on BCR/ABL1-mediated signaling, mainly including genes involved in signal transduction, e.g. the JAK/STAT, MAPK, TGFB, and insulin signaling pathways, and in regulation of metabolism. Interestingly, BCR/ABL1 was found to activate several genes involved in negative feedback regulation (CISH, SOCS2, SOCS3, PIM1, DUSP6, and TNFAIP3), which may act to indirectly suppress the tumor promoting effects exerted by BCR/ABL1. In addition, several genes identified as deregulated upon BCR/ABL1 expression could be assigned to the TGFB and NFkB signaling pathways, as well as to reflect the metabolic adjustments needed for rapidly growing cells. Apart from providing important pathogenetic insights into BCR/ABL1-mediated leukemogenesis, the present study also provides a number of pathways/individual genes that may provide attractive targets for future development of targeted therapies. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat.
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| 7. |
- Karlsson, Martin, et al.
(författare)
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Measurement of the differential cross section for the two-body photodisintegration of He-3 at theta(LAB)=90 degrees using tagged photons in the energy range 14-31 MeV
- 2009
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:4
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Tidskriftsartikel (refereegranskat)abstract
- The two-body photodisintegration of He-3 has been investigated using tagged photons with energies from 14-31 MeV at MAX-lab in Lund, Sweden. The two-body breakup channel was unambiguously identified by the (nonsimultaneous) detection of both protons and deuterons. This approach was made feasible by the overdetermined kinematic situation afforded by the tagged-photon technique. Proton-and deuteron-energy spectra were measured using four silicon surface-barrier detector telescopes located at a laboratory angle of 90 degrees with respect to the incident photon-beam direction. Average statistical and systematic uncertainties of 5.7% and 6.6% in the differential cross section were obtained for 11 photon-energy bins with an average width of 1.2 MeV. The results are compared to previous experimental data measured at comparable photon energies as well as to the results of two recent Faddeev calculations which employ realistic potential models and take into account three-nucleon forces and final-state interactions. Both the accuracy and precision of the present data are improved over those obtained in the previous measurements. The data are in good agreement with most of the previous results, and favor the inclusion of three-nucleon forces in the calculations.
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| 8. |
- Lilljebjörn, Henrik, et al.
(författare)
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Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region
- 2007
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 21:10, s. 2137-2144
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Tidskriftsartikel (refereegranskat)abstract
- Seventeen ETV6/RUNX1-positive pediatric acute lymphoblastic leukemias were investigated by high-resolution array-based comparative genomic hybridization ( array CGH), gene expression profiling and fluorescence in situ hybridization. Comparing the array CGH and gene expression patterns revealed that genomic imbalances conferred a great impact on the expression of genes in the affected regions. The array CGH analyses identified a high frequency of cytogenetically cryptic genetic changes, for example, del(9p) and del(12p). Interestingly, a duplication of Xq material, varying between 30 and 60Mb in size, was found in 6 of 11 males (55%), but not in females. Genes on Xq were found to have a high expression level in cases with dup(Xq); a similar overexpression was confirmed in t(12;21)-positive cases in an external gene expression data set. By studying the expression profile and the proposed function of genes in the minimally gained region, several candidate target genes (SPANXB, HMGB3, FAM50A, HTATSF1 and RAP2C) were identified. Among them, the testis-specific SPANXB gene was the only one showing a high and uniform overexpression, irrespective of gender and presence of Xq duplication, suggesting that this gene plays an important pathogenetic role in t(12;21)-positive leukemia.
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| 9. |
- Nilsson, Björn, et al.
(författare)
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Cross-platform classification in microarray-based leukemia diagnostics
- 2006
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Ingår i: Haematologica. - 1592-8721 .- 0390-6078. ; 91:6, s. 821-824
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Tidskriftsartikel (refereegranskat)abstract
- Gene expression profiling is a powerful technique for classifying hematologic malignancies. Its clinical use is, however, currently hindered by the need to collect large sets of expression profiles at each diagnostic facility. To overcome this limitation, we introduced cross-platform classification, allowing classifier construction using pre-existing microarray datasets. As proof-of-principle, we performed cross-platform classification of acute myeloid leukemia and childhood acute lymphoblastic leukemia using expression data from four different facilities. We show that cross-platform classification of these disorders is achievable, and, strikingly, that the diagnostic accuracy can be retained. We conclude that cross-platform classification constitutes an effective and convenient way to implement microarray diagnostics.
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| 10. |
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