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- Bereketoglu, Ceyhun, et al.
(författare)
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The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse
- 2021
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Ingår i: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 102, s. 43-55
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Tidskriftsartikel (refereegranskat)abstract
- The brominated flame retardants (BFRs), 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane (TBECH) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) bind to the androgen receptor (AR). In vitro bioassays have shown that TBECH is a potent androgen agonist while DPTE is a potent AR antagonist. Both TBECH and DPTE alter gene expression associated with AR regulation. However, it remains to be determined if TBECH and DPTE can affect the prostate. For this reason, we exposed CD1 mice to a 1:1 mixture of TBECH diastereomers α and β, a 1:1 mixture of γ and δ, and to DPTE, and tested their effects on prostate growth, histology and gene expression profiles. Castrated (C) mice were used to study the androgenic effects of TBECHαβ and TBECHγδ while the antagonistic effects of DPTE were studied in non-castrated (NC) mice. We observed that testosterone and TBECHγδ increased body and prostate weights while TBECHαβ affected neither of them; and that DPTE had no effect on body weight but reduced prostate weight drastically. Histomorphometric analysis of the prostate revealed epithelial and glandular alterations in the TBECHγδ group comparable to those in testosterone group while alterations in the TBECHαβ group were less pronounced. DPTE displayed androgen antagonist activity reminiscent of castration. The transcription profile of the prostate was altered by castration and exposure to testosterone and to TBECHγδ reversed several of these changes. Testosterone and TBECHγδ also regulated the expression of several androgen responsive genes implicated in prostate growth and cancer. While DPTE resulted in a drastic reduction in prostate weight, it only affected a small number of genes. The results indicate that TBECHγδ and DPTE are of high human health concern as they may contribute to changes in prostate growth, histology and function.
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- Olsson, Christopher, 1988-
(författare)
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Encountering the meeting place : The production of public space in contemporary Swedish planning
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A common theme in contemporary Swedish planning discussions is that we no longer meet each other in public spaces. This perceived lack of interpersonal meetings and encounters is said to reinforce the use ofstereotypes and create further distance between differences in the city. The fundamental idea behind this argument is the perception of public space as threatening and insecure, which works as a barrier to the necessary meetings. Consequently, public spaces are rapidly being reconceptualized, redeveloped and repurposed into meeting places. In this conceptualization, the meeting place is intended to generate new social relations that transcend social boundaries and perceptions of belonging, support economic development, and revitalize representative democracy.This thesis explores the production of public space as meeting place with the aim of critically discussing and nuancing the practices and ideasthat are currently leading this process. Mobilizing the production of space as its theoretical framework and using empirical material collected through interviews, observations, and planning documents from three mid-sized cities in Sweden, this research seeks to understand how the meeting place is conceptualized and how it can be understood within Swedish municipal planning. The thesis discusses the discrepancies between vision and practice, abstract and concrete space, by focusing on representations of the meeting place and the practices employed to materialize them. The researchshows that the meeting place in Swedish planning is to be understood as a dominant representation of space, which is represented through the articulation of a specific public while it is building on a consensusoriented production of meaning in a specific material context. This, I argue, contributes to reconceptualizing social problems into questions of form that can be resolved by planning rather than by politics.
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