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- Haghighi, Mona, et al.
(författare)
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A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
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| 3. |
- Andersson, Eva, et al.
(författare)
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The metabolism of vitamin A to 3,4-didehydroretinol can be demonstrated in human keratinocytes, melanoma cells and HeLa cells, and is correlated to cellular retinoid-binding protein expression
- 1994
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Ingår i: Biochimica et Biophysica Acta. Molecular Cell Research. - : Elsevier BV. - 0167-4889 .- 1879-2596. ; 1224:3, s. 349-354
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Tidskriftsartikel (refereegranskat)abstract
- Conversion of retinol to 3,4-didehydroretinol is probably a rate-limiting step in the formation of 3,4-didehydroretinoic acid, a candidate ligand for nuclear retinoid receptors in human epidermal keratinocytes. To investigate whether this metabolic pathway also exists in other cell systems, we compared the retinoid concentrations and the bioconversion of [3H]retinol to [3H]3,4-didehydroretinol in human primary keratinocytes, human cervical carcinoma (HeLa) cells, human melanoma (JKM86-4) cells, monkey kidney epithelium (CV-1) cells, and murine teratocarcinoma (F9) cells. The cellular retinol concentration ranged from 2.33 to 99.1 pmol/mg protein with the highest values observed in keratinocytes. 3,4-Didehydroretinol was only detected in cells of human origin and its concentration ranged from 0.24 pmol/mg in HeLa to 34.6 pmol/mg in the keratinocytes. Incubation with [3H]retinol for 1–24 h resulted in a rapid appearance of [3H]3,4-didehydroretinol in human keratinocytes, and to a lesser extent in HeLa and melanoma cells, but not in the other cells. Analysis of cellular retinol- and retinoic acid-binding protein concentrations showed a correlation to the cells' ability to accumulate 3,4-didehydroretinol, suggesting a role for these proteins in the 3,4-didehydro metabolic pathway. The combined results suggest that although 3,4-didehydroretinol is most typical for human keratinocytes, studies of its metabolism are also feasible in HeLa cells which contain low levels of retinoid-binding proteins.
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- Wimark, Thomas, 1979-
(författare)
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Beyond Bright City Lights : The Migration Patterns of Gay Men and Lesbians
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- One of the most persistent popular notions of gay men and lesbians is that they either live in or move to larger cities. In this thesis, the geography and migration paths of gay men and lesbians are studied using the life course perspective to challenge this idea. It is argued that gay men and lesbians are affected by the time and place into which they are born. Like heterosexuals, they are subject to the normative conceptions of life paths that are present at a specific historical period and place. Adopting a mixed-methods approach, four studies related to this aim are conducted.The first study shows that the tendency for gay men and lesbians to be concentrated to the largest cities in Sweden is greater than for heterosexuals. However, it also shows that the concentration tendency of lesbians and couples is less strong. The second study illustrates that tolerance plays no role in the geographical concentration of gay men and lesbians. Although perceived tolerance is often assumed to matter, this study shows that measured intolerance does not have an effect on the concentration tendency. The third study explores the migration motives of gay men and lesbians living in the city of Malmö, Sweden. It shows that the life stories of older cohorts resembled typical rural-urban flight stories but that the youngest cohort stressed motives similar to the overall population. This is in sharp contrast to the fourth study, which scrutinises migration stories from Izmir, Turkey. Because legal recognition is lacking, following the same life path as heterosexuals is problematic for gay men and lesbians. Because moving out is connected to this path, they remained living at home longer or never moved. Accordingly, the family played a core role in their lives rather than the rural-urban binary.Taken together, these four studies show that the geography and migration patterns of gay men and lesbians are more multifaceted than living in or moving to a larger city.
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