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- Djurfeldt, Göran, et al.
(författare)
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Afrint database
- 2011
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Rubér, Marie, et al.
(författare)
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Dysregulated Th1/Th17 response in advanced appendicitis
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: The pathogenesis of appendicitis, the most common abdominal emergency for surgical intervention, is still unknown. Epidemiological differences between perforated and nonperforated appendicitis, polymorphism in the interleukin (IL)-6 gene associated with severity of appendicitis and a more pronounced Th1/Th17-like deviation in advanced compared to phlegmonous appendicitis has been reported. Altogether these findings may indicate that appendicitis harbours two different entities with different immuno-pathogenesis, one progressing to gangrene and perforation and one resolving. In this study we aimed to further investigate systemic cytokine profiles in a large sample of patients, with advanced and phlegmonous appendicitis from a Th1, Th2, Th17 and innate perspective, and also clarify if time as duration of symptoms could explain the differences.Methods: Blood samples were preoperatively collected from patients with advanced (n=61) and phlegmonous appendicitis (n=108). The Th1-associated (IFN-γ, IL-12p70), Th2-associated (IL-4, IL-5), Th17-associated (IL-17, IL-6, CCL20, CCL2) and innate-associated (IL-1β, IL-6, MPO, CXCL8, GM-CSF), markers were analyzed in plasma using multiplex bead assay.Results: Patients with advanced appendicitis had increased levels of IL-6 (P=0.0001), CCL2 (P=0.001), MPO (P=0.039), IL-12p70 (P=0.010) and CCL20 (P=0.002) as compared to phlegmonous appendicitis and age, sex or duration of symptoms at sampling could not explain the differences.Conclusion: The findings suggest a dysregulated Th1/Th17 type inflammation in advanced appendicitis, already early in the disease course, that eventuates in gangrene and perforation and gives further support to the notion of appendicitis as two entities.
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| 5. |
- Wieslander, E, et al.
(författare)
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Antioxidative properties of organotellurium compounds in cell systems
- 1998
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Ingår i: BIOCHEMICAL PHARMACOLOGY. - : PERGAMON-ELSEVIER SCIENCE LTD. ; 55:5
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The protective/antioxidative properties of diaryl tellurides were demonstrated in cellular systems of increasing complexity. In the presence of glutathione, bis(4-hydroxyphenyl) celluride (1a), bis(4-aminophenyl) telluride (1d) and bis(2-carboxyphenyl) t
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