Sökning: WFRF:(Andersson Irene)
> Svensson L >
Increased atheroscl...
Increased atherosclerotic lesion area in apoE deficient mice overexpressing bovine growth hormone
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- Andersson, Irene, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Ljungberg, Anna, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Wallenberg Laboratory,Institute of Neuroscience and Physiology, Department of Physiology
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Svensson, L. (författare)
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- Gan, Li-Ming, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Oscarsson, J. (författare)
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- Bergström, Göran, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150. ; 188:2, s. 331-40
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human growth hormone (GH) excess is linked to increased cardiovascular morbidity and mortality. However, little is known about the effect of GH excess on atherosclerosis. We developed a new mouse model to assess the hypothesis that GH overexpression accelerates atherosclerotic lesion formation. apoE(-/-) mice were crossed with bovine GH (bGH) transgenic mice to yield apoE(-/-) mice overexpressing bGH (apoE(-/-)/bGH). The mice were fed either standard or Western diet. At 22 weeks, atherosclerotic lesion area of thoracic aorta was larger in apoE(-/-)/bGH mice compared with littermate apoE(-/-) mice fed either diet (standard: +161+/-50%, Western: +430+/-134%). Aortic sinus lesions were more severe in apoE(-/-)/bGH mice fed standard diet compared with littermate apoE(-/-) mice. apoE(-/-)/bGH mice had lower (VLDL+LDL)/HDL ratios compared with littermate apoE(-/-) mice, while systolic blood pressure was higher in apoE(-/-)/bGH mice, irrespective of diet. The levels of serum amyloid A and hepatic CRP mRNA were higher in apoE(-/-)/bGH mice than in littermate apoE(-/-) mice. In conclusion, this study shows that excess GH augments the development of atherosclerosis in apoE(-/-) mice. The mechanisms could be direct effects of GH on cellular processes in the vessel wall or the result of concomitant processes such as hypertension or a general inflammatory state.
Nyckelord
- Animals
- Aorta/*pathology
- Apolipoproteins E/*deficiency/genetics
- Atherosclerosis/metabolism/*pathology
- Blood Pressure
- C-Reactive Protein/genetics/metabolism
- Crosses
- Genetic
- DNA Primers
- *Diet
- *Disease Models
- Animal
- Growth Hormone/genetics/*metabolism
- Mice
- Mice
- Knockout
- Serum Amyloid A Protein/metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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