SwePub - sökning: WFRF:(Andersson Irene)

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1.	Andersson, Iréne, et al. (författare) Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty. 2001 Ingår i: Canadian journal of anaesthesia = Journal canadien d'anesthésie. - 0832-610X. ; 48:3, s. 251-5 Tidskriftsartikel (refereegranskat)abstract PURPOSE: To determine whether salvaged autologous blood collected postoperatively contains complement split products (SC5b-9), and pro-inflammatory cytokines (IL-6 and IL-8) and whether there are any differences between blood collected during hip or knee surgery. METHODS: Fifty-eight consecutive patients undergoing hip or knee replacement surgery were studied. Thirty-eight had postoperative bleeding large enough to require infusion of salvaged blood. The salvaged blood was filtered during collection through a 200 microm filter and before infusion a 40 microm filter was used. Samples for complement and cytokine determinations were drawn from the circulation and from the collected blood. RESULTS: High concentrations of SC5b-9, IL-6, and IL-8 were found in salvaged blood. The concentrations were higher than in the circulation (P < 0.05). The circulating concentrations of IL-6 and IL-8 were increased 60 min and 12-18 hr after transfusion. There were no differences regarding SC5b-9, IL-6, and IL-8 in the blood collected after hip or knee surgery. CONCLUSION: Blood collected from a surgical wound contains large concentrations of inflammatory mediators. There were no differences between blood collected during hip or knee surgery.
2.	Andersson, Iréne, et al. (författare) Inflammatory mediators in drained blood after hip and knee arthoplasties. 2000 Ingår i: NATA: 1th Annual meeting , Barcelona, Spain. Konferensbidrag (refereegranskat)

Andersson, Iréne, et al. (författare)
Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty.
2001
Ingår i: Canadian journal of anaesthesia = Journal canadien d'anesthésie. - 0832-610X. ; 48:3, s. 251-5
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To determine whether salvaged autologous blood collected postoperatively contains complement split products (SC5b-9), and pro-inflammatory cytokines (IL-6 and IL-8) and whether there are any differences between blood collected during hip or knee surgery. METHODS: Fifty-eight consecutive patients undergoing hip or knee replacement surgery were studied. Thirty-eight had postoperative bleeding large enough to require infusion of salvaged blood. The salvaged blood was filtered during collection through a 200 microm filter and before infusion a 40 microm filter was used. Samples for complement and cytokine determinations were drawn from the circulation and from the collected blood. RESULTS: High concentrations of SC5b-9, IL-6, and IL-8 were found in salvaged blood. The concentrations were higher than in the circulation (P < 0.05). The circulating concentrations of IL-6 and IL-8 were increased 60 min and 12-18 hr after transfusion. There were no differences regarding SC5b-9, IL-6, and IL-8 in the blood collected after hip or knee surgery. CONCLUSION: Blood collected from a surgical wound contains large concentrations of inflammatory mediators. There were no differences between blood collected during hip or knee surgery.

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