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- Ström, Kristoffer, et al.
(författare)
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Genetic variation at RAB3GAP2 and its role in exercise-related adaptation and recovery
- 2021
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Skeletal muscle fiber composition and capillary density influence physical performance and whole-body metabolic properties. ~45% of the variance in fiber type is heritable, which motivated us to perform a genome-wide association study of skeletal muscle histology from 656 Swedish men. Four independent variants were associated (p
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| 3. |
- Ahlgren, Kerstin, M., et al.
(författare)
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Type I Interferon signature in Nova Scotia duck tolling retriever dogs with steroid responsive meningitis-arteritis
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objective: Dogs of the breed Nova Scotia duck tolling retriever (NSDTR) are prone to develop a disease complex in some aspects resembling human systemic lupus erythematosus (SLE). Peripheral blood mononuclear cells (PBMCs) from human SLE patients have an increased mRNA expression type I interferon (IFN) regulated genes. However, it is unknown whether diseased dogs also display the typical type I IFN signature. Methods: To test canine sera for their capacity to induce type I IFN response Mardin-Darby canine kidney (MDCK) cells were cultured with sera from healthy dogs (n=25), immune-mediated rheumatic disease (IMRD) dogs with anti-nuclear antibodies (ANA+) (n=30) or dogs with steroid responsive meningitis-arteritis (SRMA) (n=25). mRNA expression of the genes MX1, IFIT1 and CXCL10 was measured by quantitative Real Time PCR. Results: A highly significant (p=0.0009) increase in mRNA expression of the type I IFN responsive gene MX1 was detected in cells stimulated by sera from dogs with SRMA, but not from IMRD ANA+ dogs. Expression of IFIT1 was twice as high in cells stimulated by sera from dogs with SRMA compared to both healthy dogs and ANA+ dogs. The mean expression of CXCL10 was nearly ten times higher in cells stimulated by sera from SRMA dogs than by ANA+ dogs and four times higher compared to cells stimulated by control dogs. Conclusion: Presence of type I IFN in sera from diseased NSDTR dogs was found in this study. This implies that this canine model can be used for identification of pathways of importance for autoimmune disorders in humans and for testing of novel therapeutic approaches. Our results can also be a step on the way towards personalized drugs in these dogs.
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| 6. |
- Alneberg, Johannes, et al.
(författare)
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Genomes from uncultivated prokaryotes: a comparison of metagenome-assembled and single-amplified genomes
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Prokaryotes dominate the biosphere and regulate biogeochemical processes essential to all life. Yet, our knowledge about their biology is for the most part limited to the minority that has been successfully cultured. Molecular techniques now allow for obtaining genome sequences of uncultivated prokaryotic taxa, facilitating in-depth analyses that may ultimately improve our understanding of these key organisms.Results: We compared results from two culture-independent strategies for recovering bacterial genomes: single-amplified genomes and metagenome-assembled genomes. Single-amplified genomes were obtained from samples collected at an offshore station in the Baltic Sea Proper and compared to previously obtained metagenome-assembled genomes from a time series at the same station. Among 16 single-amplified genomes analyzed, seven were found to match metagenome-assembled genomes, affiliated with a diverse set of taxa. Notably, genome pairs between the two approaches were nearly identical (>98.7% identity) across overlapping regions (30-80% of each genome). Within matching pairs, the single-amplified genomes were consistently smaller and less complete, whereas the genetic functional profiles were maintained. For the metagenome-assembled genomes, only on average 3.6% of the bases were estimated to be missing from the genomes due to wrongly binned contigs; the metagenome assembly was found to cause incompleteness to a higher degree than the binning procedure.Conclusions: The strong agreement between the single-amplified and metagenome-assembled genomes emphasizes that both methods generate accurate genome information from uncultivated bacteria. Importantly, this implies that the research questions and the available resources are allowed to determine the selection of genomics approach for microbiome studies.
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| 7. |
- Andersson, Anna
(författare)
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Ett öppet klassrumsklimat är viktigt för elevers demokratilärande
- 2023
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Ingår i: Skolforskningsportalen. - Stockholm : Skolforskningsinstitutet.
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Annan publikation (populärvet., debatt m.m.)abstract
- Skolan har ett viktigt demokratiuppdrag och undervisningens utformning påverkar elevers lärande. Ett öppet klassrumsklimat där elever bjuds in att fråga, diskutera och komma med synpunkter på ämnesinnehållet är det i särklass viktigaste för att skapa förutsättningar för demokratilärande – oavsett skolämne.
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| 8. |
- Andersson, Angelica, et al.
(författare)
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Mode Choice Latent Class Estimation on Mobile Network Data
- 2024
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Ingår i: SSRN Electronic Journal. - : Elsevier BV. - 1556-5068.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we use a nested latent class logit specification to define and estimate a large-scale mode choice demand forecasting model. We estimate this model based on mobile phone network data translated to roughly 100 000 long-distance trips within Sweden, achieving convergence of the model and credible parameter estimates. We develop methods to address two problems stemming from the nature of this data: the difficulties of distinguishing bus trips from car trips (since they share the same infrastructure) and distinguishing business from private trips (since trip purpose is unknown). To address the first issue, we estimate a nested logit model with an artificial nest that accounts for the differences in utility between bus and car. To address the latter issue, we estimate a latent class model, identifying classes of trips interpreted as private and business trips. Addressing these two issues substantially improves model fit.
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| 10. |
- Andersson, Felicia, et al.
(författare)
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Resedagbok England/Wales - Arkitektur & teknik 2018
- 2018
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Denna resedagbok är en del av Arkitektur och teknik- studenternas förberedelse för årskurs 3 och särskilt en träning i att söka, upptäcka och iakkta arkitekturens komplexa sammanhang och de värden som kan skapas genom arkitektur. Under studieresan byggs ett grundmaterial till dagboken upp genom förberedda presentationer, gemensamma analyser, undersökande skisser och konstnärliga övningar. Studieresan följs upp och bearbetas vid seminarier och genom korsläsning av texter där studenterna uppmanas till ett personligt reflekterande hållningssätt. På så sätt blir dagboken ett levande dokument som visar vår glädje och nyfikenhet över de många broar och byggnader vi upplevt tillsammans, och ett dokument som vill locka oss och alla läsare till vidare upptäcktsfärder.
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