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| 2. |
- Andersson, S. Peter, et al.
(författare)
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Thermal conductivity, heat capacity, and compressibility of atactic poly(propylene) under high pressure
- 1997
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Ingår i: International journal of thermophysics. - : Springer Science and Business Media LLC. - 0195-928X .- 1572-9567. ; 18:3, s. 845-864
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Tidskriftsartikel (refereegranskat)abstract
- The thermal conductivity λ and the heat capacity per unit volume of atactic poly(propylene) have been measured in the temperature range 90–420 K at pressures up to 1.5 GPa using the transient hot-wire method. The bulk modulus has been measured in the range 200–295 K and up to 0.7 GPa. These data were used to calculate the volume dependence of λ, g=−[∂λ/λ)/(∂V/V)]T, which yielded the following values for the glassy state (T<256 K at atmospheric pressure): 3.80±0.19 at 200 K, 3.74±0.19 at 225 K, 3.90±0.20 at 250 K, 3.77±0.19 at 271 K, and 3.73±0.19 at 297 K. The resultant value for g of the liquid state was 3.61±0.15 at 297 K. Values for g which are calculated at 295 K, using theoretical models of λ(T), agree to within 12% with the experimental value for the glassy state.
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| 3. |
- Andersson, S. Peter, et al.
(författare)
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Thermal conductivity of amorphous Teflon (AF 1600) at high pressure
- 1997
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Ingår i: International journal of thermophysics. - : Springer Nature. - 0195-928X .- 1572-9567. ; 18:1, s. 209-219
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Tidskriftsartikel (refereegranskat)abstract
- The thermal conductivity, λ, of amorphous Teflon AF 1600 [poly(1,3-dioxole-4,5-difluoro-2,2-bis(trifluoromethyl)-co-tetrafluoroethylene)] has been measured at pressures up to 2 GPa in the temperature range 93–392 K. At 295 K and atmospheric pressure, we obtained λ=0.116 W·m−1·K−1. The bulk modulus was measured up to 1.0 GPa in the temperature range 150–296 K and the combined data yielded the following values of g=(∂ln λ/∂ln V)T :2.8±0.2 at 296 K, 3.0±0.2 at 258 K, 3.0±0.2 at 236 K, 3.4±0.2 at 200 K, and 3.4±0.2 at 150 K.
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| 4. |
- Rafati, Nima, et al.
(författare)
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Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies
- 2016
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Ingår i: G3. - : Oxford University Press (OUP). - 2160-1836. ; 6:7, s. 2213-2223
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Tidskriftsartikel (refereegranskat)abstract
- Skeletal atavism in Shetland ponies is a heritable disorder characterized by abnormal growth of the ulna and fibula that extend the carpal and tarsal joints, respectively. This causes abnormal skeletal structure and impaired movements, and affected foals are usually killed. In order to identify the causal mutation we subjected six confirmed Swedish cases and a DNA pool consisting of 21 control individuals to whole genome resequencing. We screened for polymorphisms where the cases and the control pool were fixed for opposite alleles and observed this signature for only 25 SNPs, most of which were scattered on genome assembly unassigned scaffolds. Read depth analysis at these loci revealed homozygosity or compound heterozygosity for two partially overlapping large deletions in the pseudoautosomal region (PAR) of chromosome X/Y in cases but not in the control pool. One of these deletions removes the entire coding region of the SHOX gene and both deletions remove parts of the CRLF2 gene located downstream of SHOX. The horse reference assembly of the PAR is highly fragmented, and in order to characterize this region we sequenced bacterial artificial chromosome (BAC) clones by single-molecule real-time (SMRT) sequencing technology. This considerably improved the assembly and enabled size estimations of the two deletions to 1602180 kb and 60280 kb, respectively. Complete association between the presence of these deletions and disease status was verified in eight other affected horses. The result of the present study is consistent with previous studies in humans showing crucial importance of SHOX for normal skeletal development.
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| 5. |
- Tonpheng, Bounphanh, 1959-, et al.
(författare)
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Tensile strength and young's modulus of polyisoprene/single-wall carbon nanotube composites increased by high pressure cross-linking
- 2010
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Ingår i: Macromolecules. - : American Chemical Society. - 0024-9297 .- 1520-5835. ; 43:18, s. 7680-7688
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Tidskriftsartikel (refereegranskat)abstract
- High-viscosity liquid cis-1,4 polyisoprene (PI), with up to 20 wt % single-wall carbon nanotubes (SWCNTs), has been cross-linked by high pressure and high temperature (HP&HT) treatment at 513 K and pressures in the range 0.5 to 1.5 GPa to yield densified network polymer composites. A composite with 5 wt % SWCNTs showed 2.2 times higher tensile strength σUTS (σUTS = 17 MPa), 2.3 times higher Young’s modulus E (E = 220 MPa) and longer extension at break than pure PI. The improvement is attributed to SWCNT reinforcement and improved SWCNT−PI interfacial contact as a result of the HP&HT cross-linking process, and reduced brittleness despite a higher measured cross-link density than that of pure PI. The latter may originate from an effect similar to crazing, i.e., bridging of microcracks by polymer fibrils. We surmise that the higher cross-link densities of the composites are due mainly to physical cross-links/constraints caused by the SWCNT−PI interaction, which also reflects the improved interfacial contact, and that the CNTs promote material flow by disrupting an otherwise chemically cross-linked network. We also deduce that the PI density increase at HP&HT cross-linking is augmented by the presence of CNTs.
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| 6. |
- Ali, Imran, et al.
(författare)
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Exposure to polychlorinated biphenyls and prostate cancer : population-based prospective cohort and experimental studies
- 2016
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Ingår i: Carcinogenesis. - : Oxford University Press. - 0143-3334 .- 1460-2180. ; 37:12, s. 1144-1151
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Tidskriftsartikel (refereegranskat)abstract
- Polychlorinated biphenyls (PCBs) are highly persistent environmental pollutants and are undesirable components of our daily food. PCBs are classified as human carcinogens, but the evidence for prostate cancer is limited and available data are inconsistent. We explored the link between non-dioxin-like PCB and grade of prostate cancer in a prospective cohort as well as in cell experiments. A population-based cohort of 32496 Swedish men aged 45-79 years was followed prospectively through 1998-2011, to assess the association between validated estimates of dietary PCB exposure and incidence of prostate cancer by grade (2789 cases, whereof 1276 low grade, 756 intermediate grade, 450 high grade) and prostate cancer mortality (357 fatal cases). In addition, we investigated a non-dioxin-like PCB153-induced cell invasion and related markers in normal prostate stem cells (WPE-stem) and in three different prostate cancer cell lines (PC3, DU145 and 22RV1) at exposure levels relevant to humans. After multivariable-adjustment, dietary PCB exposure was positively associated with high-grade prostate cancer, relative risk (RR) 1.35 [95% confidence interval (CI): 1.03-1.76] and with fatal prostate cancer, RR 1.43 (95% CI: 1.05-1.95), comparing the highest tertile with the lowest. We observed no association with low or intermediate grade of prostate cancer. Cell invasion and related markers, including MMP9, MMP2, Slug and Snail, were significantly increased in human prostate cancer cells as well as in prostate stem cells after exposure to PCB153. Our findings both from the observational and experimental studies suggest a role of non-dioxin-like PCB153 in the development of high-grade and fatal prostate cancer.
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| 7. |
- Alm, Ove, et al.
(författare)
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A multiple coaxial wire for pressure calibration
- 1974
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Ingår i: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 45:4, s. 594-595
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Tidskriftsartikel (refereegranskat)abstract
- A single wire containing several metals suitable for pressure calibration has been produced by extrusion. Coaxial combinations of Ce-Bi-TI and Ce-Bi-Ba have been prepared by the procedure described.
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| 10. |
- Almgren, Torbjörn, 1959, et al.
(författare)
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Diabetes in treated hypertension is common and carries a high cardiovascular risk: results from a 28-year follow-up.
- 2007
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Ingår i: Journal of hypertension. - 0263-6352. ; 25:6, s. 1311-7
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The objective of this study was to analyse predictive factors for development of type 2 diabetes during life-long therapy for hypertension and the alleged additional cardiovascular risk this constitutes. METHODS: The study group (n = 754) comprised the hypertensive subgroup of a randomized population sample of 7500 men, aged 47-54 years, screened for cardiovascular risk factors and followed for 25-28 years. The patients were treated with thiazide diuretics and beta-adrenergic blocking drugs with the addition of hydralazin during the first decade. Calcium antagonists were substituted for hydralazin and, if needed, angiotensin-converting enzyme inhibitors were added when these drugs became available. RESULTS: A total of 148 (20.4%) treated hypertensive patients developed diabetes during 25 years, and in multivariate Cox regression analysis body mass index, serum triglycerides and treatment with beta-blockers were positively related with this complication. New-onset diabetes implied a significantly increased risk for stroke [hazard ratio (HR): 1.67; 95% confidence interval (95% CI): 1.1-2.6; P < 0.05], myocardial infarction (OR: 1.66; 95% CI: 1.1-2.5; P < 0.05) and mortality (OR: 1.42; 95% CI: 1.1-1.9; P < 0.05). The greatest risk for stroke was new-onset diabetes, followed by smoking (OR: 1.46; 95% CI: 1-2.2; P = 0.07) and the greatest risk for myocardial infarction was new-onset diabetes, followed by smoking (HR: 1.64; 95% CI: 1.1-2.4; P < 0.01). The greatest risk for mortality was smoking (HR: 1.73; 95% CI: 1.3-2.2; P < 0.005). Achieved systolic and diastolic blood pressure were not predictive of cardiovascular complications or death. The mean observation time from onset of diabetes mellitus to a first stroke was 9.1 years and to a first myocardial infarction 9.3 years. CONCLUSION: Diabetes in treated hypertensive patients is alarmingly common and carries a high risk for cardiovascular complications and mortality.
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