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| 2. |
- Furukawa, T. A., et al.
(författare)
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Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual data
- 2021
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Ingår i: Lancet Psychiatry. - : Elsevier BV. - 2215-0374 .- 2215-0366. ; 8:6, s. 500-511
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Tidskriftsartikel (refereegranskat)abstract
- Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42.0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD -1.83 [95% credible interval (CrI) -2.90 to -0.80]) and that relaxation might be harmful (1.20 [95% CrI 0.17 to 2.27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and automated encouragement reduced dropouts from treatment (incremental odds ratio, 0.32 [95% CrI 0.13 to 0.93]). The risk of bias was low for the randomisation process, missing outcome data, or selection of reported results in most of the included studies, uncertain for deviation from intended interventions, and high for measurement of outcomes. There was moderate to high heterogeneity among the studies and their components. 511
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- Carlbring, P., Forslin, P., Willebrand, M., Ljungstrand, P., Strandlund, C., Ekselius, L., & Andersson, G
(författare)
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Is the Internet-Administered CIDI-SF Equivalent to a Clinician-Administered SCID-Interview?
- 2002
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Ingår i: Cognitive behaviour therapy. ; 31, s. 183-189
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Tidskriftsartikel (refereegranskat)abstract
- The procedural validity of the Composite International Diagnostic Interview - short form (CIDI-SF) administered via an Internet web-page was examined and compared with an in-person interview (Structured Clinical Interview for DSM-IV Axis I Disorders, rese
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| 5. |
- Carlbring, P., Forslin, P., Willebrand, M., Ljungstrand, P., Strandlund, C., Ekselius, L., & Andersson, G.
(författare)
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Is the web-administrated CIDI-SF equivalent to a human SCID-interview?.
- 2002
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Ingår i: European Psychiatry. ; 17:Suppl. 1, s. 151-
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Lång, P, et al.
(författare)
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Expression and secretion of the novel adipokine tartrate-resistant acid phosphatase from adipose tissues of obese and lean women
- 2011
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 35:12, s. 1502-1510
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Tartrate-resistant acid phosphatase (TRAP) expressed by adipose tissue macrophages (ATMs) induces mice obesity and human adipocyte differentiation in vitro. This study aimed to investigate whether TRAP was secreted differently from human obese versus lean adipose tissues and to identify the cellular source of adipose tissue TRAP.Design: Subcutaneous adipose tissues obtained from healthy subjects. Enzyme-linked immunosorbent assays (ELISAs) for total (5a+5b) and cleaved TRAP (5b) were used. TRAP secretion was determined in adipose tissue biopsies, and mRNA expression was studied in cell types isolated from the same.Subjects: Results of 24 lean and 24 obese women (in vitro) and 8 subjects (in vivo) were compared. The main outcome measurements were TRAP expression and secretion in vitro and in vivo.Results: In-house total TRAP ELISA showed high sensitivity and a coefficient of variance of 11%. Adipose secretion of total TRAP was linear in vitro with time and was evident in vivo. Total TRAP secretion in vitro was similar in lean and obese women expressed per unit weight of the adipose tissue but correlated positively with the number/size of adipocytes (P≤0.01) and with adipose secretion of tumor necrosis factor-α and interleukin-6 (P<0.01). TRAP 5b was not secreted from the adipose tissue. ATMs displayed highest cellular expression of TRAP mRNA in adipose tissue cells derived from lean or obese women.Conclusions: TRAP is a novel human adipokine produced by macrophages and secreted from the subcutaneous adipose tissue in vivo and in vitro. Secretion is linked to the size and number of adipocytes, as well as to concomitant secretion of inflammatory mediators, suggesting that TRAP is involved in fat accumulation and adipose inflammation. International Journal of Obesity advance online publication, 8 March 2011; doi:10.1038/ijo.2011.17.
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| 9. |
- Nilsson, K. -F, et al.
(författare)
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A probabilistic methodology to determine acceptance criteria and failure probabilities for the KBS-3 ductile cast iron inserts
- 2006
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Ingår i: Mater Res Soc Symp Proc. - : Springer Science and Business Media LLC. - 1558998896 - 9781558998896 ; , s. 275-282
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Konferensbidrag (refereegranskat)abstract
- The Swedish KBS-3 copper-cast iron canisters for geological disposal are in an advanced stage of its development. This reports deals with the cast iron insert that provides the mechanical strength of the canister. The ductility of manufactured inserts often fall below the initial requirements [1]. An issue then was what consequences low tensile properties and scatter may have on the long-term failure probability of the canisters. This paper describes an approach to assess the failure probabilities for given actual material data and how to derive acceptance criteria for manufactured canisters. A statistical test programme was implemented using three inserts to determine the tensile, compression and fracture properties. Tested specimens were investigated by micro-structural analysis to determine the microstructure and categorize and size defects. It was found that the material scatter and low ductility was caused by many defect types, but with slag defects as the most important ones. These data were then used to compute defect distributions and as direct input to FE-calculations of KBS-3 canisters. A large number of FE-analyses were performed at the maximum design load (44 MPa) covering distributions of material parameters and geometrical features of the canisters. The computed probabilities were very low for both failure modes even for material data with poor ductility.
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| 10. |
- Nilsson, K. -F, et al.
(författare)
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A probabilistic methodology to determine failure probabilities and acceptance criteria for the KBS-3 inserts under ice-age load conditions
- 2006
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Ingår i: Proc. 11th Int. High Lvl, Radioactive Waste Managem. Conf. IHLRWM. - 0894486918 - 9780894486913 ; , s. 207-214
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Konferensbidrag (refereegranskat)abstract
- The Swedish KBS-3 copper-cast iron canister for geological disposal is in an advanced stage. This reports deals with the cast iron insert that provides the mechanical strength of the canister and outlines an approach to assess the failure probabilities at large isostatic pressure (44 MPa) for manufactured canisters and how to derive acceptance criteria. The work includes a statistical test programme using three inserts for the tensile, compression and fracture properties. Specimens used for material characterization were also investigated by micro-structural analysis to determine the microstructure and to classify and size defects. It was found that the material scatter and low ductility was caused by many defect types, but with slag defects in the form of oxidation films as the most important one. These data were then used to compute defect distributions and as direct input to FE-calculations of KBS-3 canisters. A large number of FE-analyses were performed at the maximum design load (44 MPa) covering distributions of material parameters and geometrical features of the canisters. The computed probabilities for fracture and plastic collapse were very low even for material data with poor ductility. Two large scale isostatic compression tests of KBS-3 mock-ups to assess safety margins are also described. The failure occurred at loads above 130 MPa in both cases, indicating a safety margin of at least a factor three against the maximum design load.
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