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Träfflista för sökning "WFRF:(Andersson Patrik) ;lar1:(oru)"

Sökning: WFRF:(Andersson Patrik) > Örebro universitet

  • Resultat 1-10 av 28
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1.
  • Alijagic, Andi, 1992-, et al. (författare)
  • A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles
  • 2023
  • Ingår i: Cells. - : MDPI. - 2073-4409. ; 12:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Additive manufacturing (AM) or industrial 3D printing uses cutting-edge technologies and materials to produce a variety of complex products. However, the effects of the unintentionally emitted AM (nano)particles (AMPs) on human cells following inhalation, require further investigations. The physicochemical characterization of the AMPs, extracted from the filter of a Laser Powder Bed Fusion (L-PBF) 3D printer of iron-based materials, disclosed their complexity, in terms of size, shape, and chemistry. Cell Painting, a high-content screening (HCS) assay, was used to detect the subtle morphological changes elicited by the AMPs at the single cell resolution. The profiling of the cell morphological phenotypes, disclosed prominent concentration-dependent effects on the cytoskeleton, mitochondria, and the membranous structures of the cell. Furthermore, lipidomics confirmed that the AMPs induced the extensive membrane remodeling in the lung epithelial and macrophage co-culture cell model. To further elucidate the biological mechanisms of action, the targeted metabolomics unveiled several inflammation-related metabolites regulating the cell response to the AMP exposure. Overall, the AMP exposure led to the internalization, oxidative stress, cytoskeleton disruption, mitochondrial activation, membrane remodeling, and metabolic reprogramming of the lung epithelial cells and macrophages. We propose the approach of integrating Cell Painting with metabolomics and lipidomics, as an advanced nanosafety methodology, increasing the ability to capture the cellular and molecular phenotypes and the relevant biological mechanisms to the (nano)particle exposure.
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2.
  • Bergknut, Magnus, et al. (författare)
  • Identification of potentially toxic compounds in complex extracts of environmental samples using gas chromatography-mass spectrometry and multivariate data analysis
  • 2007
  • Ingår i: Environmental Toxicology and Chemistry. - New York : Pergamon. - 0730-7268 .- 1552-8618. ; 26:2, s. 208-217
  • Tidskriftsartikel (refereegranskat)abstract
    • In this study, we examined 31 samples of varying chemical composition, including samples of soils from gasworks, coke production sites, and sites where wood preservatives were heavily used; ash and soot from municipal solid waste incinerators; antiskid sand; and dust from areas with heavy road traffic. The samples were comprehensively chemically characterized, especially their polycyclic aromatic compound contents, using gas chromatography-time-of-flight mass spectrometry, whereas their biological effects were assessed using dehydrogenase activity, root growth (Hordeum vulgare), reproduction of springtails (Folsomia candida), algal growth (Desmodesmus subspicatus), germinability (Sinapis alba), Vibrio fischeri, DR-CALUX, and Ames Salmonella assays. The number of compounds detected in the samples ranged from 123 to 527. Using the multivariate regression technique of partial-least-squares projections to latent structures, it was possible to find individual compounds that exhibited strong correlations with the different biological responses. Some of the results, however, indicate that a broader chemical characterization may be needed to identify all the compounds that may cause the measured biological responses.
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3.
  • Alijagic, Andi, 1992-, et al. (författare)
  • Particle Safety Assessment in Additive Manufacturing : From Exposure Risks to Advanced Toxicology Testing.
  • 2022
  • Ingår i: Frontiers in Toxicology. - : Frontiers Media S.A.. - 2673-3080. ; 4
  • Tidskriftsartikel (refereegranskat)abstract
    • Additive manufacturing (AM) or industrial three-dimensional (3D) printing drives a new spectrum of design and production possibilities; pushing the boundaries both in the application by production of sophisticated products as well as the development of next-generation materials. AM technologies apply a diversity of feedstocks, including plastic, metallic, and ceramic particle powders with distinct size, shape, and surface chemistry. In addition, powders are often reused, which may change the particles' physicochemical properties and by that alter their toxic potential. The AM production technology commonly relies on a laser or electron beam to selectively melt or sinter particle powders. Large energy input on feedstock powders generates several byproducts, including varying amounts of virgin microparticles, nanoparticles, spatter, and volatile chemicals that are emitted in the working environment; throughout the production and processing phases. The micro and nanoscale size may enable particles to interact with and to cross biological barriers, which could, in turn, give rise to unexpected adverse outcomes, including inflammation, oxidative stress, activation of signaling pathways, genotoxicity, and carcinogenicity. Another important aspect of AM-associated risks is emission/leakage of mono- and oligomers due to polymer breakdown and high temperature transformation of chemicals from polymeric particles, both during production, use, and in vivo, including in target cells. These chemicals are potential inducers of direct toxicity, genotoxicity, and endocrine disruption. Nevertheless, understanding whether AM particle powders and their byproducts may exert adverse effects in humans is largely lacking and urges comprehensive safety assessment across the entire AM lifecycle-spanning from virgin and reused to airborne particles. Therefore, this review will detail: 1) brief overview of the AM feedstock powders, impact of reuse on particle physicochemical properties, main exposure pathways and protective measures in AM industry, 2) role of particle biological identity and key toxicological endpoints in the particle safety assessment, and 3) next-generation toxicology approaches in nanosafety for safety assessment in AM. Altogether, the proposed testing approach will enable a deeper understanding of existing and emerging particle and chemical safety challenges and provide a strategy for the development of cutting-edge methodologies for hazard identification and risk assessment in the AM industry.
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4.
  • Andersson, H., et al. (författare)
  • Transcriptional profiling of the peripheral blood response during tularemia
  • 2006
  • Ingår i: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 7:6, s. 503-513
  • Tidskriftsartikel (refereegranskat)abstract
    • Tularemia is a febrile disease caused by the highly contagious bacterium Francisella tularensis. We undertook an analysis of the transcriptional response in peripheral blood during the course of ulceroglandular tularemia by use of Affymetrix microarrays comprising 14,500 genes. Samples were obtained from seven individuals at five occasions during 2 weeks after the first hospital visit and convalescent samples 3 months later. In total, 265 genes were differentially expressed, 95 of which at more than one time point. The differential expression was verified with real-time quantitative polymerase chain reaction for 36 genes (R(2)=0.590). The most prominent changes were noted in samples drawn on days 2-3 and a considerable proportion of the upregulated genes appeared to represent an interferon-gamma-induced response and also a proapoptotic response. Genes involved in the generation of innate and acquired immune responses were found to be downregulated, presumably a pathogen-induced event. A logistic regression analysis revealed that seven genes were good predictors of the early phase of tularemia. This is the first description of the transcriptional host response to ulceroglandular tularemia and the study has identified gene subsets relevant to the pathogenesis of the disease and subsets that may serve as early diagnostic biomarkers.
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5.
  • Andersson Järnberg, Linda, 1969-, et al. (författare)
  • Kommunal bolagisering : ett ständigt aktuellt ämne
  • 2024
  • Ingår i: Kommunal ekonomi. - : Kommunalekonomernas förening. - 0282-0099 .- 2002-3995. ; :1, s. 41-42
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Så länge kommuner har funnits har de även haft bolag och ständigt har detta varit ett ämne för debatt, där farhågor för demokratin och konkurrens lyfts. I en nyligen publicerad rapport studerar vi framväxten av kommunala bolag och granskar produktivitetsutvecklingen i dessa, som enligt beslutsfattare är ett av de viktigaste motiven till verksamhet i bolagsform.
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6.
  • Andersson Järnberg, Linda, 1969-, et al. (författare)
  • Kommunala bolag i Sverige : att förstå framväxten av dessa och produktivitetsutvecklingen över tid
  • 2023
  • Rapport (populärvet., debatt m.m.)abstract
    • Svenska kommuner äger och bedriver sedan länge verksamhet i bolagsform, men står ut i internationell jämförelse genom det stora antalet kommunala bolag och storleken på dessa. Antalet bolag fortsätter dessutom att öka och spelar en viktig roll i kommunsektorns utveckling och de välfärdstjänster som sektorn tillhandahåller. Vad kan förklara denna utveckling? Baserat på data för perioden 2000-2020 finner vi att befolkningststorleken är positivt korrelerad med antalet bolag. Det tenderar alltså att vara så att stora kommuner har fler bolag än små kommuner, men befolkningsstorleken förklarar däremot inte varför bolagen i en genomsnittlig kommun växer i omfång i termer av antal anställda per invånare. Vidare finns det samband som indikerar att de kommunala bolagen i en genomsnittlig kommun blir fler och växer i termer av andel sysselsatta när skatteunderlaget ökar och den lokala arbetslösheten stiger. Vad gäller de strukturella mönstren tycks det existera lokala kluster av geografiskt närliggande kommuner med många kommunala bolag. Detta kan tyda på att kommuner imiterar varandra. När vi studerar produktiviteten i de enskilda bolagen så finner vi att de presterar ungefär lika bra som sina privata motsvarigheter. Produktivitetsutvecklingen i ett genomsnittligt kommunalt bolag skiljer sig i de flesta fall inte från ett privat bolag i samma bransch, med undantag för en bransch där den är lägre och en annan bransch där den är högre.
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7.
  • Andersson, Linda, 1969-, et al. (författare)
  • Firm level effects of offshoring of goods and services on relative labor demand
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Based on firm level data for the Swedish manufacturing sector the objective of this paper is to analyze relative labor demand effects due to offshoring. Actual firm-level trade data allow us to distinguish between goods and service offshoring, as well as sourcing country. Overall, our results give no support to the fears that offshoring of goods or services lead to out-location of high-skilled activity in Swedish firms. Rather, this paper finds robust evidence that the aggregate effects from offshoring lead to increasing relative demand of high-skilled labor, mainly due to serviceoffshoring to middle income countries.
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8.
  • Andersson, Linda, 1969-, et al. (författare)
  • Firm-level effects of offshoring of materials and services on relative labor demand
  • 2016
  • Ingår i: Review of World Economics. - : Springer. - 1610-2878 .- 1610-2886. ; 152:2, s. 321-350
  • Tidskriftsartikel (refereegranskat)abstract
    • Based on firm-level data over the period 1997-2002 for the Swedish manufacturing sector the objective of this paper is to analyze relative labor demand effects due to offshoring, separating between materials and services offshoring and also geographical location of trade partner. Overall, our results give no support to the fears that offshoring of materials or services lead to out-location of high-skilled activity in Swedish firms. Rather, this paper finds evidence that the aggregate effects from offshoring lead to increasing relative demand of high-skilled labor, mainly due to services offshoring to middle income countries.
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9.
  • Andersson, Linda, 1969-, et al. (författare)
  • Labour Demand, Offshoring and Inshoring : Evidence from Swedish Firm-level Data
  • 2017
  • Ingår i: The World Economy. - : John Wiley & Sons. - 0378-5920 .- 1467-9701. ; 40:2, s. 240-274
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this paper was to analyse effects on firm–level relative demand for skilled labour due to imports of intermediates (offshoring) and exports of intermediates (inshoring). The study is based on a data set of Swedish manufacturing firms, 1997–2002, using trade flows in intermediate goods and services, respectively. Descriptive data show that goods inshoring is much larger than goods offshoring, while the reverse is true for services. There is, however, a strong increase in services inshoring over the study period. Controlling for potential endogeneity in offshoring and inshoring, our results indicate that there is a positive effect of services offshoring on the skill composition of workers in Swedish firms, while no such causality can be established from inshoring.
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10.
  • Andersson, Linda, et al. (författare)
  • Offshoring and relative labor demand in Swedish firms
  • 2007
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The objective of this paper is to analyze relative employment effects in Sweden due to offshoring. In contrast to most previous studies in this field, our analysis is based on firm level data. More specifically the dataset contains Swedish manufacturing firms, 1997-2002. In addition we have access to actual firm level import data on intermediate goods and services, respectively. The results show that the relative demand for high skilled labor is positively affected by service offshoring and offshoring of goods to Asia, but negatively affected by offshoring to high income countries. The relative demand for medium skilled labor is negatively affected by offshoring of goods to Eastern Europe, but positively affected by offshoring to high income countries. In contrast to expectations, the results show that the relative demand for low skilled labor is positively affected by offshoring of goods to Eastern Europe. However, these results are related to very small elasticities, which in turn translates into a small number of jobs affected.
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